Compile Data Set for Download or QSAR
maximum 50k data
Found 93 of ic50 for UniProtKB: P25021
TargetHistamine H2 receptor(Homo sapiens (Human))
7Tm Pharma

Curated by ChEMBL
LigandPNGBDBM50172414(2-(2,4-Dichloro-phenoxy)-N-[2-(2-dimethylamino-eth...)
Affinity DataIC50:  0.870nMAssay Description:Inhibitory concentration against histamine H2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H2 receptor(Homo sapiens (Human))
7Tm Pharma

Curated by ChEMBL
LigandPNGBDBM22568(1-cyano-3-{2-[({2-[(diaminomethylidene)amino]-1,3-...)
Affinity DataIC50:  22nMAssay Description:Displacement of [125I]Aminopotentidine from human recombinant histamine H2 receptor expressed in CHOK1 cells after 2 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H2 receptor(Homo sapiens (Human))
7Tm Pharma

Curated by ChEMBL
LigandPNGBDBM50156855(3-(2-(4-(1-(2-ethoxyethyl)-1H-indol-3-yl)piperidin...)
Affinity DataIC50:  123nMAssay Description:Displacement of [3H]ketanserine from histamine H2 receptor in human cortex membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H2 receptor(Homo sapiens (Human))
7Tm Pharma

Curated by ChEMBL
LigandPNGBDBM50403559(Brumetadina | CIMETIDINE)
Affinity DataIC50:  140nMAssay Description:Binding affinity to human histamine H2 receptor by radioligand displacement assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H2 receptor(Homo sapiens (Human))
7Tm Pharma

Curated by ChEMBL
LigandPNGBDBM392076(US10301272, Example 7/9)
Affinity DataIC50:  142nMAssay Description:Displacement of [125I]APT from human recombinant histamine H2 receptor after 120 mins by scintillation counting analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistamine H2 receptor(Homo sapiens (Human))
7Tm Pharma

Curated by ChEMBL
LigandPNGBDBM50156856(2-(2-(4-(1-(2-ethoxyethyl)-1H-indol-3-yl)piperidin...)
Affinity DataIC50:  225nMAssay Description:Displacement of [3H]ketanserine from histamine H2 receptor in human cortex membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H2 receptor(Homo sapiens (Human))
7Tm Pharma

Curated by ChEMBL
LigandPNGBDBM50156857(2-(2-(4-(1-(2-ethoxyethyl)-6-fluoro-1H-indol-3-yl)...)
Affinity DataIC50:  260nMAssay Description:Displacement of [3H]ketanserine from histamine H2 receptor in human cortex membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H2 receptor(Homo sapiens (Human))
7Tm Pharma

Curated by ChEMBL
LigandPNGBDBM50403559(Brumetadina | CIMETIDINE)
Affinity DataIC50:  270nMAssay Description:Binding affinity to human histamine H2 receptor by radioligand displacement assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H2 receptor(Homo sapiens (Human))
7Tm Pharma

Curated by ChEMBL
LigandPNGBDBM50105105(CHEMBL116463 | {1-[4,4-Bis-(4-fluoro-phenyl)-butyl...)
Affinity DataIC50:  368nMAssay Description:Inhibition of histamine H2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H2 receptor(Homo sapiens (Human))
7Tm Pharma

Curated by ChEMBL
LigandPNGBDBM50156900(2-(2-(4-(1-(2-ethoxyethyl)-5-fluoro-1H-indol-3-yl)...)
Affinity DataIC50:  500nMAssay Description:Displacement of [3H]ketanserine from histamine H2 receptor in human cortex membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H2 receptor(Homo sapiens (Human))
7Tm Pharma

Curated by ChEMBL
LigandPNGBDBM181119(US9138393, Cimetidine | US9144538, Cimetidine)
Affinity DataIC50:  500nMAssay Description:Displacement of [125I]APT from human recombinant histamine H2 receptor expressed in CHO cells after 120 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H2 receptor(Homo sapiens (Human))
7Tm Pharma

Curated by ChEMBL
LigandPNGBDBM50156892(2-(2-(4-(1-(thiophen-2-ylmethyl)-1H-indol-3-yl)pip...)
Affinity DataIC50:  500nMAssay Description:Displacement of [3H]ketanserine from histamine H2 receptor in human cortex membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H2 receptor(Homo sapiens (Human))
7Tm Pharma

Curated by ChEMBL
LigandPNGBDBM50156878(2-(2-(4-(1-(2-ethoxyethyl)-1H-indol-3-yl)piperidin...)
Affinity DataIC50:  500nMAssay Description:Displacement of [3H]ketanserine from histamine H2 receptor in human cortex membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H2 receptor(Homo sapiens (Human))
7Tm Pharma

Curated by ChEMBL
LigandPNGBDBM50156887(3-[4-(1-furan-2-ylmethyl-1H-indol-3-yl)piperidin-1...)
Affinity DataIC50:  630nMAssay Description:Displacement of [3H]ketanserine from histamine H2 receptor in human cortex membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H2 receptor(Homo sapiens (Human))
7Tm Pharma

Curated by ChEMBL
LigandPNGBDBM50156894(4-(2-(4-(1-(2-ethoxyethyl)-1H-indol-3-yl)piperidin...)
Affinity DataIC50:  691nMAssay Description:Displacement of [3H]ketanserine from histamine H2 receptor in human cortex membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H2 receptor(Homo sapiens (Human))
7Tm Pharma

Curated by ChEMBL
LigandPNGBDBM50105102(4-[4,4-Bis-(4-fluoro-phenyl)-butyl]-piperazine-1-c...)
Affinity DataIC50:  757nMAssay Description:Inhibition of histamine H2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H2 receptor(Homo sapiens (Human))
7Tm Pharma

Curated by ChEMBL
LigandPNGBDBM50156893(2-(2-{4-[1-(2-Ethoxy-ethyl)-1H-indol-3-yl]-piperid...)
Affinity DataIC50:  779nMAssay Description:Displacement of [3H]ketanserine from histamine H2 receptor in human cortex membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H2 receptor(Homo sapiens (Human))
7Tm Pharma

Curated by ChEMBL
LigandPNGBDBM50156875(2-(2-(4-(1-(2-ethoxyethyl)-1H-indol-3-yl)piperidin...)
Affinity DataIC50:  850nMAssay Description:Displacement of [3H]ketanserine from histamine H2 receptor in human cortex membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H2 receptor(Homo sapiens (Human))
7Tm Pharma

Curated by ChEMBL
LigandPNGBDBM50172421((E)-N-{2-[(2-Dimethylamino-ethyl)-methyl-amino]-4-...)
Affinity DataIC50:  860nMAssay Description:Inhibitory concentration against Histamine H2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H2 receptor(Homo sapiens (Human))
7Tm Pharma

Curated by ChEMBL
LigandPNGBDBM50156886(2-{2-[4-(6-fluoro-1-furan-2-ylmethyl-1H-indol-3-yl...)
Affinity DataIC50:  870nMAssay Description:Displacement of [3H]ketanserine from histamine H2 receptor in human cortex membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H2 receptor(Homo sapiens (Human))
7Tm Pharma

Curated by ChEMBL
LigandPNGBDBM50156876(2-{2-[4-(6-fluoro-1-furan-3-ylmethyl-1H-indol-3-yl...)
Affinity DataIC50:  880nMAssay Description:Displacement of [3H]ketanserine from histamine H2 receptor in human cortex membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H2 receptor(Homo sapiens (Human))
7Tm Pharma

Curated by ChEMBL
LigandPNGBDBM50156890(5-acetyl-2-(2-(4-(1-(2-ethoxyethyl)-1H-indol-3-yl)...)
Affinity DataIC50:  950nMAssay Description:Displacement of [3H]ketanserine from histamine H2 receptor in human cortex membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H2 receptor(Homo sapiens (Human))
7Tm Pharma

Curated by ChEMBL
LigandPNGBDBM50103595(Brumetadina | CHEBI:3699 | Cimetidine | Tagamet | ...)
Affinity DataIC50:  1.00E+3nMAssay Description:Displacement of [125I]APT from human recombinant H2 receptor expressed in CHO cells measured after 120 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H2 receptor(Homo sapiens (Human))
7Tm Pharma

Curated by ChEMBL
LigandPNGBDBM50103595(Brumetadina | CHEBI:3699 | Cimetidine | Tagamet | ...)
Affinity DataIC50:  1.00E+3nMAssay Description:Displacement of [125I]APT from human recombinant histamine H2 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H2 receptor(Homo sapiens (Human))
7Tm Pharma

Curated by ChEMBL
LigandPNGBDBM50330441(3-amino-2-(4-(4-(quinolin-2-yl)piperazin-1-yl)buty...)
Affinity DataIC50: >1.00E+3nMAssay Description:Displacement of [125I]APT from human recombinant histamine H2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H2 receptor(Homo sapiens (Human))
7Tm Pharma

Curated by ChEMBL
LigandPNGBDBM50260582(CHEMBL4086541)
Affinity DataIC50:  1.00E+3nMAssay Description:Displacement of [125I]-aminopotentidine receptor from histamine H2 receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H2 receptor(Homo sapiens (Human))
7Tm Pharma

Curated by ChEMBL
LigandPNGBDBM50156861(2-(2-(4-(1-((5-chlorothiophen-2-yl)methyl)-6-fluor...)
Affinity DataIC50:  1.03E+3nMAssay Description:Displacement of [3H]ketanserine from histamine H2 receptor in human cortex membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H2 receptor(Homo sapiens (Human))
7Tm Pharma

Curated by ChEMBL
LigandPNGBDBM50105109(4-[4,4-Bis-(4-fluoro-phenyl)-butyl]-piperazine-1-c...)
Affinity DataIC50:  1.03E+3nMAssay Description:Inhibition of histamine H2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H2 receptor(Homo sapiens (Human))
7Tm Pharma

Curated by ChEMBL
LigandPNGBDBM50156863(2-(2-{4-[6-fluoro-1-(2-methoxyethyl)-1H-indol-3-yl...)
Affinity DataIC50:  1.19E+3nMAssay Description:Displacement of [3H]ketanserine from histamine H2 receptor in human cortex membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H2 receptor(Homo sapiens (Human))
7Tm Pharma

Curated by ChEMBL
LigandPNGBDBM50105101(4-[4,4-Bis-(4-fluoro-phenyl)-butyl]-piperazine-1-c...)
Affinity DataIC50:  1.25E+3nMAssay Description:Inhibition of histamine H2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H2 receptor(Homo sapiens (Human))
7Tm Pharma

Curated by ChEMBL
LigandPNGBDBM50156884(3-[4-(1-thiophen-2-ylmethyl-1H-indol-3-yl)piperidi...)
Affinity DataIC50:  1.33E+3nMAssay Description:Displacement of [3H]ketanserine from histamine H2 receptor in human cortex membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H2 receptor(Homo sapiens (Human))
7Tm Pharma

Curated by ChEMBL
LigandPNGBDBM50105103(1-{4-[4,4-Bis-(4-fluoro-phenyl)-butyl]-piperazin-1...)
Affinity DataIC50:  1.34E+3nMAssay Description:Inhibition of histamine H2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H2 receptor(Homo sapiens (Human))
7Tm Pharma

Curated by ChEMBL
LigandPNGBDBM50156860(2-(2-(4-(7-bromo-1-(2-ethoxyethyl)-1H-indol-3-yl)p...)
Affinity DataIC50:  1.40E+3nMAssay Description:Displacement of [3H]ketanserine from histamine H2 receptor in human cortex membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H2 receptor(Homo sapiens (Human))
7Tm Pharma

Curated by ChEMBL
LigandPNGBDBM50156877(5-[4-(6-fluoro-1-furan-3-ylmethyl-1H-indol-3-yl)pi...)
Affinity DataIC50:  1.50E+3nMAssay Description:Displacement of [3H]ketanserine from histamine H2 receptor in human cortex membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H2 receptor(Homo sapiens (Human))
7Tm Pharma

Curated by ChEMBL
LigandPNGBDBM50156859(2-(2-(4-(5-bromo-1-(2-ethoxyethyl)-1H-indol-3-yl)p...)
Affinity DataIC50:  1.50E+3nMAssay Description:Displacement of [3H]ketanserine from histamine H2 receptor in human cortex membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H2 receptor(Homo sapiens (Human))
7Tm Pharma

Curated by ChEMBL
LigandPNGBDBM50156871(3-{4-[1-(2-Ethoxy-ethyl)-1H-indol-3-yl]-piperidin-...)
Affinity DataIC50:  1.77E+3nMAssay Description:Displacement of [3H]ketanserine from histamine H2 receptor in human cortex membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H2 receptor(Homo sapiens (Human))
7Tm Pharma

Curated by ChEMBL
LigandPNGBDBM50156882(2-(2-(4-(1-((5-chlorothiophen-2-yl)methyl)-1H-indo...)
Affinity DataIC50:  1.86E+3nMAssay Description:Displacement of [3H]ketanserine from histamine H2 receptor in human cortex membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H2 receptor(Homo sapiens (Human))
7Tm Pharma

Curated by ChEMBL
LigandPNGBDBM50156891(2-(3-((4-(1-(2-ethoxyethyl)-1H-indol-3-yl)piperidi...)
Affinity DataIC50:  1.92E+3nMAssay Description:Displacement of [3H]ketanserine from histamine H2 receptor in human cortex membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H2 receptor(Homo sapiens (Human))
7Tm Pharma

Curated by ChEMBL
LigandPNGBDBM50105107(1-{4-[4,4-Bis-(4-fluoro-phenyl)-butyl]-piperazin-1...)
Affinity DataIC50:  1.98E+3nMAssay Description:Inhibition of histamine H2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H2 receptor(Homo sapiens (Human))
7Tm Pharma

Curated by ChEMBL
LigandPNGBDBM50156881(2-(2-((4-(1-(2-ethoxyethyl)-1H-indol-3-yl)piperidi...)
Affinity DataIC50:  2.10E+3nMAssay Description:Displacement of [3H]ketanserine from histamine H2 receptor in human cortex membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H2 receptor(Homo sapiens (Human))
7Tm Pharma

Curated by ChEMBL
LigandPNGBDBM50156864(2-(2-(4-(1-(2-(1,4-dioxan-2-yl)ethyl)-1H-indol-3-y...)
Affinity DataIC50:  2.10E+3nMAssay Description:Displacement of [3H]ketanserine from histamine H2 receptor in human cortex membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H2 receptor(Homo sapiens (Human))
7Tm Pharma

Curated by ChEMBL
LigandPNGBDBM50156879(2-{2-[4-(1-butyl-6-fluoro-1H-indol-3-yl)piperidin-...)
Affinity DataIC50:  2.15E+3nMAssay Description:Displacement of [3H]ketanserine from histamine H2 receptor in human cortex membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H2 receptor(Homo sapiens (Human))
7Tm Pharma

Curated by ChEMBL
LigandPNGBDBM50156852(2-(2-(4-(1-(2-(pyridin-2-yl)ethyl)-1H-indol-3-yl)p...)
Affinity DataIC50:  2.90E+3nMAssay Description:Displacement of [3H]ketanserine from histamine H2 receptor in human cortex membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H2 receptor(Homo sapiens (Human))
7Tm Pharma

Curated by ChEMBL
LigandPNGBDBM50156895(2-(2-(4-(1-(2-ethoxyethyl)-6-(trifluoromethyl)-1H-...)
Affinity DataIC50:  2.90E+3nMAssay Description:Displacement of [3H]ketanserine from histamine H2 receptor in human cortex membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H2 receptor(Homo sapiens (Human))
7Tm Pharma

Curated by ChEMBL
LigandPNGBDBM50156866(5-[4-(6-fluoro-1-thiophen-2-ylmethyl-1H-indol-3-yl...)
Affinity DataIC50:  3.00E+3nMAssay Description:Displacement of [3H]ketanserine from histamine H2 receptor in human cortex membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H2 receptor(Homo sapiens (Human))
7Tm Pharma

Curated by ChEMBL
LigandPNGBDBM50156854(2-((4-(1-(2-ethoxyethyl)-1H-indol-3-yl)piperidin-1...)
Affinity DataIC50:  3.05E+3nMAssay Description:Displacement of [3H]ketanserine from histamine H2 receptor in human cortex membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H2 receptor(Homo sapiens (Human))
7Tm Pharma

Curated by ChEMBL
LigandPNGBDBM50156874(5-{4-[1-(5-chlorothiophen-2-ylmethyl)-6-fluoro-1H-...)
Affinity DataIC50:  3.06E+3nMAssay Description:Displacement of [3H]ketanserine from histamine H2 receptor in human cortex membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H2 receptor(Homo sapiens (Human))
7Tm Pharma

Curated by ChEMBL
LigandPNGBDBM50156888(2-(2-(4-(1-(2-ethoxyethyl)-7-methyl-1H-indol-3-yl)...)
Affinity DataIC50:  3.10E+3nMAssay Description:Displacement of [3H]ketanserine from histamine H2 receptor in human cortex membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H2 receptor(Homo sapiens (Human))
7Tm Pharma

Curated by ChEMBL
LigandPNGBDBM50156872(2-methoxy-5-[4-(1-thiophen-2-ylmethyl-1H-indol-3-y...)
Affinity DataIC50:  3.20E+3nMAssay Description:Displacement of [3H]ketanserine from histamine H2 receptor in human cortex membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H2 receptor(Homo sapiens (Human))
7Tm Pharma

Curated by ChEMBL
LigandPNGBDBM50156867(2-(2-{4-[1-(2-Ethoxy-ethyl)-1H-indol-3-yl]-piperid...)
Affinity DataIC50:  3.27E+3nMAssay Description:Displacement of [3H]ketanserine from histamine H2 receptor in human cortex membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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