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Found 263 of ic50 for UniProtKB: P21451
TargetEndothelin receptor type B(RAT)
Tanabe Seiyaku

Curated by ChEMBL
LigandPNGBDBM50107561(CHEMBL168441 | N-[6-[2-(5-Bromo-pyrimidin-2-yloxy)...)
Affinity DataIC50: >1nMAssay Description:In vitro inhibition of [125 I]ET-1 binding to Endothelin B receptor (ETB-receptor) in rat cerebellum membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin receptor type B(RAT)
Tanabe Seiyaku

Curated by ChEMBL
LigandPNGBDBM50105048(CHEMBL112144 | N-[6-[2-(5-Bromo-pyrimidin-2-yloxy)...)
Affinity DataIC50: >1nMAssay Description:In vitro inhibition of [125 I]ET-1 binding to Endothelin B receptor (ETB-receptor) in rat cerebellum membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin receptor type B(RAT)
Tanabe Seiyaku

Curated by ChEMBL
LigandPNGBDBM50107562(CHEMBL168119 | N-[6-[2-(5-Bromo-pyrimidin-2-yloxy)...)
Affinity DataIC50: >1nMAssay Description:In vitro inhibition of [125 I]ET-1 binding to Endothelin B receptor (ETB-receptor) in rat cerebellum membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin receptor type B(RAT)
Tanabe Seiyaku

Curated by ChEMBL
LigandPNGBDBM50000558(CHEMBL437472 | ET-1 | Endothelin -1 | Endothelin 1...)
Affinity DataIC50:  1.60nMAssay Description:Inhibition of ET-1 binding to Endothelin B receptor in cultured rat cerebellar membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin receptor type B(RAT)
Tanabe Seiyaku

Curated by ChEMBL
LigandPNGBDBM50093997(4-(6-Chloro-benzo[1,3]dioxol-5-ylmethyl)-2-cyclohe...)
Affinity DataIC50:  1.70nMAssay Description:In vitro binding affinity to endothelin B receptor in rat cerebellumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin receptor type B(RAT)
Tanabe Seiyaku

Curated by ChEMBL
LigandPNGBDBM50093993(4-(6-Chloro-benzo[1,3]dioxol-5-ylmethyl)-2-cyclohe...)
Affinity DataIC50:  2.60nMAssay Description:In vitro binding affinity to endothelin B receptor in rat cerebellumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin receptor type B(RAT)
Tanabe Seiyaku

Curated by ChEMBL
LigandPNGBDBM50093996(4-(6-Chloro-benzo[1,3]dioxol-5-ylmethyl)-2-cyclohe...)
Affinity DataIC50:  3.20nMAssay Description:In vitro binding affinity to endothelin B receptor in rat cerebellumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin receptor type B(RAT)
Tanabe Seiyaku

Curated by ChEMBL
LigandPNGBDBM50093995(2-(2-Carboxymethoxy-cyclohexylmethyl)-4-(6-chloro-...)
Affinity DataIC50:  3.20nMAssay Description:In vitro binding affinity to endothelin B receptor in rat cerebellumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin receptor type B(RAT)
Tanabe Seiyaku

Curated by ChEMBL
LigandPNGBDBM50093984(2-(2-Carboxymethoxy-benzyl)-4-(6-chloro-benzo[1,3]...)
Affinity DataIC50:  3.30nMAssay Description:In vitro binding affinity to endothelin B receptor in rat cerebellumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin receptor type B(RAT)
Tanabe Seiyaku

Curated by ChEMBL
LigandPNGBDBM50094004(4-(6-Chloro-benzo[1,3]dioxol-5-ylmethyl)-2-cyclohe...)
Affinity DataIC50:  3.40nMAssay Description:In vitro binding affinity to endothelin B receptor in rat cerebellumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin receptor type B(RAT)
Tanabe Seiyaku

Curated by ChEMBL
LigandPNGBDBM50093988(2-(2-Carboxymethoxy-4-methoxy-benzyl)-4-(6-chloro-...)
Affinity DataIC50:  4nMAssay Description:In vitro binding affinity to endothelin B receptor in rat cerebellumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin receptor type B(RAT)
Tanabe Seiyaku

Curated by ChEMBL
LigandPNGBDBM50093986(2-(2-Carboxymethoxy-benzyl)-4-(6-chloro-benzo[1,3]...)
Affinity DataIC50:  4.60nMAssay Description:In vitro binding affinity to endothelin B receptor in rat cerebellumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin receptor type B(RAT)
Tanabe Seiyaku

Curated by ChEMBL
LigandPNGBDBM50093980(2-Adamantan-1-ylmethyl-4-(6-chloro-benzo[1,3]dioxo...)
Affinity DataIC50:  4.90nMAssay Description:In vitro binding affinity to endothelin B receptor in rat cerebellumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin receptor type B(RAT)
Tanabe Seiyaku

Curated by ChEMBL
LigandPNGBDBM50093990(4-(6-Chloro-benzo[1,3]dioxol-5-ylmethyl)-2-cyclohe...)
Affinity DataIC50:  6.30nMAssay Description:In vitro binding affinity to endothelin B receptor in rat cerebellumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin receptor type B(RAT)
Tanabe Seiyaku

Curated by ChEMBL
LigandPNGBDBM50093981(2-(2-Carboxymethoxy-4-methoxy-benzyl)-4-(6-chloro-...)
Affinity DataIC50:  8.60nMAssay Description:In vitro binding affinity to endothelin B receptor in rat cerebellumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin receptor type B(RAT)
Tanabe Seiyaku

Curated by ChEMBL
LigandPNGBDBM50094001(4-(6-Chloro-benzo[1,3]dioxol-5-ylmethyl)-2-(3,5-di...)
Affinity DataIC50:  9.70nMAssay Description:In vitro binding affinity to endothelin B receptor in rat cerebellumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin receptor type B(RAT)
Tanabe Seiyaku

Curated by ChEMBL
LigandPNGBDBM50093987(4-(6-Chloro-benzo[1,3]dioxol-5-ylmethyl)-2-cyclohe...)
Affinity DataIC50:  9.80nMAssay Description:In vitro binding affinity to endothelin B receptor in rat cerebellumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin receptor type B(RAT)
Tanabe Seiyaku

Curated by ChEMBL
LigandPNGBDBM50094000(2-(3-Carboxy-cyclohexylmethyl)-4-(6-chloro-benzo[1...)
Affinity DataIC50:  9.90nMAssay Description:In vitro binding affinity to endothelin B receptor in rat cerebellumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin receptor type B(RAT)
Tanabe Seiyaku

Curated by ChEMBL
LigandPNGBDBM50032175((S)-3-[(S)-2-((S)-2-Acetylamino-3,3-diphenyl-propi...)
Affinity DataIC50:  10nMAssay Description:Binding affinity against endothelin B receptor rat cerebellar membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin receptor type B(RAT)
Tanabe Seiyaku

Curated by ChEMBL
LigandPNGBDBM50093998(4-(6-Chloro-benzo[1,3]dioxol-5-ylmethyl)-2-(3-chlo...)
Affinity DataIC50:  11nMAssay Description:In vitro binding affinity to endothelin B receptor in rat cerebellumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin receptor type B(RAT)
Tanabe Seiyaku

Curated by ChEMBL
LigandPNGBDBM50032216((S)-3-[(S)-2-((S)-2-Acetylamino-3,3-diphenyl-propi...)
Affinity DataIC50:  12nMAssay Description:Binding affinity against endothelin B receptor rat cerebellar membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin receptor type B(RAT)
Tanabe Seiyaku

Curated by ChEMBL
LigandPNGBDBM50032181(2-{1-[1-(2-carboxy-1-{1-[10,11-dihydro-5H-dibenzo[...)
Affinity DataIC50:  15nMAssay Description:Inhibitory concentration was evaluated by measuring the binding affinity at the Endothelin B receptor in rat cerebellar membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin receptor type B(RAT)
Tanabe Seiyaku

Curated by ChEMBL
LigandPNGBDBM50032181(2-{1-[1-(2-carboxy-1-{1-[10,11-dihydro-5H-dibenzo[...)
Affinity DataIC50:  15nMAssay Description:Binding affinity against endothelin B receptor rat cerebellar membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin receptor type B(RAT)
Tanabe Seiyaku

Curated by ChEMBL
LigandPNGBDBM50093999(2-(3-Carboxy-cyclohexylmethyl)-4-(6-chloro-benzo[1...)
Affinity DataIC50:  15nMAssay Description:In vitro binding affinity to endothelin B receptor in rat cerebellumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin receptor type B(RAT)
Tanabe Seiyaku

Curated by ChEMBL
LigandPNGBDBM50032202((S)-2-[(2S,3S)-2-((2S,3S)-2-{(S)-2-[(S)-2-((S)-2-A...)
Affinity DataIC50:  16nMAssay Description:Binding affinity against endothelin B receptor rat cerebellar membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin receptor type B(RAT)
Tanabe Seiyaku

Curated by ChEMBL
LigandPNGBDBM50032172((S)-3-[(S)-2-((S)-2-Acetylamino-3,3-diphenyl-propi...)
Affinity DataIC50:  20nMAssay Description:Inhibition of ET-1 stimulated arachidonic acid release in CHO cells expressing rat ET- B receptorsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin receptor type B(RAT)
Tanabe Seiyaku

Curated by ChEMBL
LigandPNGBDBM50032178((S)-N-((1S,2S)-1-{(1S,2S)-1-[(S)-1-Carboxy-2-(1H-i...)
Affinity DataIC50:  20nMAssay Description:Inhibition of ET-1 stimulated arachidonic acid release in CHO cells expressing rat ET- B receptorsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin receptor type B(RAT)
Tanabe Seiyaku

Curated by ChEMBL
LigandPNGBDBM50032166((S)-3-[(S)-2-((S)-2-Acetylamino-3-phenyl-propionyl...)
Affinity DataIC50:  20nMAssay Description:Binding affinity against endothelin B receptor rat cerebellar membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin receptor type B(RAT)
Tanabe Seiyaku

Curated by ChEMBL
LigandPNGBDBM50369269(CHEMBL1793932)
Affinity DataIC50:  20nMAssay Description:Inhibition of binding to Endothelin B receptor of rat cerebellar membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin receptor type B(RAT)
Tanabe Seiyaku

Curated by ChEMBL
LigandPNGBDBM50093991(4-(6-Chloro-benzo[1,3]dioxol-5-ylmethyl)-2-(3,4-di...)
Affinity DataIC50:  26nMAssay Description:In vitro binding affinity to endothelin B receptor in rat cerebellumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin receptor type B(RAT)
Tanabe Seiyaku

Curated by ChEMBL
LigandPNGBDBM50281565((S)-3-[(R)-2-((R)-2-Acetylamino-3-phenyl-propionyl...)
Affinity DataIC50:  30nMAssay Description:Displacement of [125I]-ET-1 from Endothelin B receptor of rat cerebellumMore data for this Ligand-Target Pair
In DepthDetails Article
TargetEndothelin receptor type B(RAT)
Tanabe Seiyaku

Curated by ChEMBL
LigandPNGBDBM50032173((S)-3-[(S)-2-((S)-2-Benzoylamino-3,3-diphenyl-prop...)
Affinity DataIC50:  30nMAssay Description:Binding affinity against endothelin B receptor rat cerebellar membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin receptor type B(RAT)
Tanabe Seiyaku

Curated by ChEMBL
LigandPNGBDBM50093992(4-(6-Chloro-benzo[1,3]dioxol-5-ylmethyl)-2-(2-ethy...)
Affinity DataIC50:  31nMAssay Description:In vitro binding affinity to endothelin B receptor in rat cerebellumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin receptor type B(RAT)
Tanabe Seiyaku

Curated by ChEMBL
LigandPNGBDBM50032180((S)-2-[(2S,3S)-2-((2S,3S)-2-{(S)-2-[(S)-2-((S)-2-A...)
Affinity DataIC50:  33nMAssay Description:Binding affinity against endothelin B receptor rat cerebellar membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin receptor type B(RAT)
Tanabe Seiyaku

Curated by ChEMBL
LigandPNGBDBM50089716(4-(6-Chloro-benzo[1,3]dioxol-5-ylmethyl)-2-(3-meth...)
Affinity DataIC50:  34nMAssay Description:In vitro binding affinity to endothelin B receptor in rat cerebellumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin receptor type B(RAT)
Tanabe Seiyaku

Curated by ChEMBL
LigandPNGBDBM50089716(4-(6-Chloro-benzo[1,3]dioxol-5-ylmethyl)-2-(3-meth...)
Affinity DataIC50:  34nMAssay Description:In vitro inhibition of [125-I] labelled ET-1 endothelin binding to Endothelin B receptor in rat cerebellumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin receptor type B(RAT)
Tanabe Seiyaku

Curated by ChEMBL
LigandPNGBDBM50045240((S)-2-[(S)-2-((2S,5S)-2-{(S)-2-[(S)-2-((R)-2-Acety...)
Affinity DataIC50:  35nMAssay Description:Displacement of [125I]-ET-1 from Endothelin B receptor of rat cerebellumMore data for this Ligand-Target Pair
In DepthDetails Article
TargetEndothelin receptor type B(RAT)
Tanabe Seiyaku

Curated by ChEMBL
LigandPNGBDBM50045240((S)-2-[(S)-2-((2S,5S)-2-{(S)-2-[(S)-2-((R)-2-Acety...)
Affinity DataIC50:  36nMAssay Description:Effective concentration against Endothelin B receptor from rat cerebellumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin receptor type B(RAT)
Tanabe Seiyaku

Curated by ChEMBL
LigandPNGBDBM50089721(4-Benzo[1,3]dioxol-5-ylmethyl-2-(3-methoxy-benzyl)...)
Affinity DataIC50:  40nMAssay Description:In vitro inhibition of [125-I] labelled ET-1 endothelin binding to Endothelin B receptor in rat cerebellumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin receptor type B(RAT)
Tanabe Seiyaku

Curated by ChEMBL
LigandPNGBDBM50366424(CHEMBL2369709)
Affinity DataIC50:  40nMAssay Description:Inhibition of [125I]-endothelin-3 [ET-3] binding to endothelin B receptor (ETB) of rat cerebellumMore data for this Ligand-Target Pair
In DepthDetails Article
TargetEndothelin receptor type B(RAT)
Tanabe Seiyaku

Curated by ChEMBL
LigandPNGBDBM50369268(CHEMBL1790519)
Affinity DataIC50:  40nMAssay Description:Inhibition of binding to Endothelin B receptor of rat cerebellar membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin receptor type B(RAT)
Tanabe Seiyaku

Curated by ChEMBL
LigandPNGBDBM50093985(2-(6-Carboxy-4H-benzo[1,3]dioxin-8-ylmethyl)-4-(6-...)
Affinity DataIC50:  44nMAssay Description:In vitro binding affinity to endothelin B receptor in rat cerebellumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin receptor type B(RAT)
Tanabe Seiyaku

Curated by ChEMBL
LigandPNGBDBM50045244((S)-3-[(S)-2-((R)-2-Acetylamino-3-phenyl-propionyl...)
Affinity DataIC50:  50nMAssay Description:Displacement of [125I]-ET-1 from Endothelin B receptor of rat cerebellumMore data for this Ligand-Target Pair
In DepthDetails Article
TargetEndothelin receptor type B(RAT)
Tanabe Seiyaku

Curated by ChEMBL
LigandPNGBDBM50032207((S)-3-[(S)-2-((S)-2-Acetylamino-3,3-diphenyl-propi...)
Affinity DataIC50:  51nMAssay Description:Binding affinity against endothelin B receptor rat cerebellar membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin receptor type B(RAT)
Tanabe Seiyaku

Curated by ChEMBL
LigandPNGBDBM50032171((S)-4-((S)-2-Acetylamino-3,3-diphenyl-propionylami...)
Affinity DataIC50:  52nMAssay Description:Binding affinity against endothelin B receptor rat cerebellar membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin receptor type B(RAT)
Tanabe Seiyaku

Curated by ChEMBL
LigandPNGBDBM50032208((S)-3-[(S)-2-((S)-2-Acetylamino-3,3-diphenyl-propi...)
Affinity DataIC50:  56nMAssay Description:Binding affinity against endothelin B receptor rat cerebellar membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin receptor type B(RAT)
Tanabe Seiyaku

Curated by ChEMBL
LigandPNGBDBM50366421(CHEMBL1791271)
Affinity DataIC50:  60nMAssay Description:Inhibition of [125I]-endothelin-3 [ET-3] binding to endothelin B receptor (ETB) of rat cerebellumMore data for this Ligand-Target Pair
In DepthDetails Article
TargetEndothelin receptor type B(RAT)
Tanabe Seiyaku

Curated by ChEMBL
LigandPNGBDBM50045244((S)-3-[(S)-2-((R)-2-Acetylamino-3-phenyl-propionyl...)
Affinity DataIC50:  60nMAssay Description:Effective concentration against Endothelin B receptor from rat cerebellumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin receptor type B(RAT)
Tanabe Seiyaku

Curated by ChEMBL
LigandPNGBDBM50284007(CHEMBL412460 | Trp-Ile-Ile-Asp-Leu-Hisc(Cys-Ser-Se...)
Affinity DataIC50:  60nMAssay Description:Binding affinity against Endothelin B receptor in rat cerebellar membrane (ET-B) from adult blue laurie ratMore data for this Ligand-Target Pair
In DepthDetails Article
TargetEndothelin receptor type B(RAT)
Tanabe Seiyaku

Curated by ChEMBL
LigandPNGBDBM50032191((S)-4-[(S)-2-((S)-2-Acetylamino-3,3-diphenyl-propi...)
Affinity DataIC50:  60nMAssay Description:Binding affinity against endothelin B receptor rat cerebellar membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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