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Found 51 of ic50 for UniProtKB: P16473
TargetThyrotropin receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50614128(CHEMBL5281228)
Affinity DataIC50:  11nMAssay Description:Allosteric antagonist activity at human TSHR expressed in CHO cells assessed as inhibition of bTSH-induced cAMP production incubated for 2 hrs by lum...More data for this Ligand-Target Pair
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TargetThyrotropin receptor(Homo sapiens (Human))TBA
LigandPNGBDBM60862(BDBM189328 | US9174940, 32)
Affinity DataIC50:  12nMAssay Description:Antagonist activity of three test compounds against human TSI at the human TSH receptor was tested in Chinese Hamster Ovary (CHO) cells (cultured 16 ...More data for this Ligand-Target Pair
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TargetThyrotropin receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50614117(CHEMBL5275472)
Affinity DataIC50:  24nMAssay Description:Antagonist activity at human TSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-F...More data for this Ligand-Target Pair
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TargetThyrotropin receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50614127(CHEMBL5267043)
Affinity DataIC50:  33nMAssay Description:Antagonist activity at human TSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-F...More data for this Ligand-Target Pair
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TargetThyrotropin receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50614105(CHEMBL5287707)
Affinity DataIC50:  35nMAssay Description:Antagonist activity at human TSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-F...More data for this Ligand-Target Pair
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TargetThyrotropin receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50614120(CHEMBL5267166)
Affinity DataIC50:  42nMAssay Description:Antagonist activity at human TSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-F...More data for this Ligand-Target Pair
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TargetThyrotropin receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50614107(CHEMBL5288869)
Affinity DataIC50:  45nMAssay Description:Antagonist activity at human TSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-F...More data for this Ligand-Target Pair
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TargetThyrotropin receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50614110(CHEMBL5270266)
Affinity DataIC50:  46nMAssay Description:Antagonist activity at human TSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-F...More data for this Ligand-Target Pair
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TargetThyrotropin receptor(Homo sapiens (Human))TBA
LigandPNGBDBM189329((+)-(1-Acetyl-4-methyl-4-phenyl-1,2,3,4-tetrahydro...)
Affinity DataIC50:  47nMAssay Description:Antagonist activity of three test compounds against human TSI at the human TSH receptor was tested in Chinese Hamster Ovary (CHO) cells (cultured 16 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetThyrotropin receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50614123(CHEMBL5286556)
Affinity DataIC50:  48nMAssay Description:Antagonist activity at human TSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-F...More data for this Ligand-Target Pair
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TargetThyrotropin receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50614106(CHEMBL5275619)
Affinity DataIC50:  49nMAssay Description:Antagonist activity at human TSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-F...More data for this Ligand-Target Pair
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TargetThyrotropin receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50614125(CHEMBL5270771)
Affinity DataIC50:  56nMAssay Description:Antagonist activity at human TSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-F...More data for this Ligand-Target Pair
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TargetThyrotropin receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50614109(CHEMBL5285685)
Affinity DataIC50:  58nMAssay Description:Antagonist activity at human TSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-F...More data for this Ligand-Target Pair
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TargetThyrotropin receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50614108(CHEMBL5290721)
Affinity DataIC50:  62nMAssay Description:Antagonist activity at human TSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-F...More data for this Ligand-Target Pair
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TargetThyrotropin receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50614104(CHEMBL5283477)
Affinity DataIC50:  65nMAssay Description:Antagonist activity at human TSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-F...More data for this Ligand-Target Pair
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TargetThyrotropin receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50614108(CHEMBL5290721)
Affinity DataIC50:  69nMAssay Description:Antagonist activity at human TSHR in HEK293 cells assessed as inhibition of bTSH-induced cAMP production incubated for 2 hrs by Eu-cAMP tracer based ...More data for this Ligand-Target Pair
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TargetThyrotropin receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50614119(CHEMBL5271120)
Affinity DataIC50:  71nMAssay Description:Antagonist activity at human TSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-F...More data for this Ligand-Target Pair
Ligand Info
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TargetThyrotropin receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50614111(CHEMBL5279687)
Affinity DataIC50:  72nMAssay Description:Antagonist activity at human TSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-F...More data for this Ligand-Target Pair
Ligand Info
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TargetThyrotropin receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50614118(CHEMBL5288635)
Affinity DataIC50:  74nMAssay Description:Antagonist activity at human TSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-F...More data for this Ligand-Target Pair
Ligand Info
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TargetThyrotropin receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50614116(CHEMBL5285143)
Affinity DataIC50:  82nMAssay Description:Antagonist activity at human TSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-F...More data for this Ligand-Target Pair
Ligand Info
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TargetThyrotropin receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50614115(CHEMBL5285769)
Affinity DataIC50:  82nMAssay Description:Antagonist activity at human TSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-F...More data for this Ligand-Target Pair
Ligand Info
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TargetThyrotropin receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50614126(CHEMBL5268829)
Affinity DataIC50:  85nMAssay Description:Antagonist activity at human TSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-F...More data for this Ligand-Target Pair
Ligand Info
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TargetThyrotropin receptor(Homo sapiens (Human))TBA
LigandPNGBDBM189327(Hexanoic acid (Compound A) | US9174940, Compound A)
Affinity DataIC50:  88nMAssay Description:Antagonist activity of three test compounds against human TSI at the human TSH receptor was tested in Chinese Hamster Ovary (CHO) cells (cultured 16 ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetThyrotropin receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50614114(CHEMBL5268512)
Affinity DataIC50:  91nMAssay Description:Antagonist activity at human TSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-F...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetThyrotropin receptor(Homo sapiens (Human))TBA
LigandPNGBDBM60860(US9174940, 31)
Affinity DataIC50: <100nMAssay Description:Antagonist activity of three test compounds against human TSI at the human TSH receptor was tested in Chinese Hamster Ovary (CHO) cells (cultured 16 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetThyrotropin receptor(Homo sapiens (Human))TBA
LigandPNGBDBM60857(US9174940, 30)
Affinity DataIC50: <100nMAssay Description:Antagonist activity of three test compounds against human TSI at the human TSH receptor was tested in Chinese Hamster Ovary (CHO) cells (cultured 16 ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetThyrotropin receptor(Homo sapiens (Human))TBA
LigandPNGBDBM60856(US9174940, 29)
Affinity DataIC50: <100nMAssay Description:Antagonist activity of three test compounds against human TSI at the human TSH receptor was tested in Chinese Hamster Ovary (CHO) cells (cultured 16 ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetThyrotropin receptor(Homo sapiens (Human))TBA
LigandPNGBDBM60855(US9174940, 28)
Affinity DataIC50: <100nMAssay Description:Antagonist activity of three test compounds against human TSI at the human TSH receptor was tested in Chinese Hamster Ovary (CHO) cells (cultured 16 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetThyrotropin receptor(Homo sapiens (Human))TBA
LigandPNGBDBM60853(US9174940, 27)
Affinity DataIC50: <100nMAssay Description:Antagonist activity of three test compounds against human TSI at the human TSH receptor was tested in Chinese Hamster Ovary (CHO) cells (cultured 16 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetThyrotropin receptor(Homo sapiens (Human))TBA
LigandPNGBDBM60848(US9174940, 11 | US9174940, 26)
Affinity DataIC50: <100nMAssay Description:Antagonist activity of three test compounds against human TSI at the human TSH receptor was tested in Chinese Hamster Ovary (CHO) cells (cultured 16 ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetThyrotropin receptor(Homo sapiens (Human))TBA
LigandPNGBDBM60851(US9174940, 18)
Affinity DataIC50: <100nMAssay Description:Antagonist activity of three test compounds against human TSI at the human TSH receptor was tested in Chinese Hamster Ovary (CHO) cells (cultured 16 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetThyrotropin receptor(Homo sapiens (Human))TBA
LigandPNGBDBM60850(US9174940, 13)
Affinity DataIC50: <100nMAssay Description:Antagonist activity of three test compounds against human TSI at the human TSH receptor was tested in Chinese Hamster Ovary (CHO) cells (cultured 16 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetThyrotropin receptor(Homo sapiens (Human))TBA
LigandPNGBDBM60849(US9174940, 12)
Affinity DataIC50: <100nMAssay Description:Antagonist activity of three test compounds against human TSI at the human TSH receptor was tested in Chinese Hamster Ovary (CHO) cells (cultured 16 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetThyrotropin receptor(Homo sapiens (Human))TBA
LigandPNGBDBM60862(BDBM189328 | US9174940, 32)
Affinity DataIC50: <100nMAssay Description:Antagonist activity of three test compounds against human TSI at the human TSH receptor was tested in Chinese Hamster Ovary (CHO) cells (cultured 16 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetThyrotropin receptor(Homo sapiens (Human))TBA
LigandPNGBDBM60872(US9174940, 40)
Affinity DataIC50: <100nMAssay Description:Antagonist activity of three test compounds against human TSI at the human TSH receptor was tested in Chinese Hamster Ovary (CHO) cells (cultured 16 ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetThyrotropin receptor(Homo sapiens (Human))TBA
LigandPNGBDBM60870(US9174940, 39)
Affinity DataIC50: <100nMAssay Description:Antagonist activity of three test compounds against human TSI at the human TSH receptor was tested in Chinese Hamster Ovary (CHO) cells (cultured 16 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetThyrotropin receptor(Homo sapiens (Human))TBA
LigandPNGBDBM60869(US9174940, 38)
Affinity DataIC50: <100nMAssay Description:Antagonist activity of three test compounds against human TSI at the human TSH receptor was tested in Chinese Hamster Ovary (CHO) cells (cultured 16 ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetThyrotropin receptor(Homo sapiens (Human))TBA
LigandPNGBDBM60867(US9174940, 37)
Affinity DataIC50: <100nMAssay Description:Antagonist activity of three test compounds against human TSI at the human TSH receptor was tested in Chinese Hamster Ovary (CHO) cells (cultured 16 ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetThyrotropin receptor(Homo sapiens (Human))TBA
LigandPNGBDBM60866(US9174940, 36)
Affinity DataIC50: <100nMAssay Description:Antagonist activity of three test compounds against human TSI at the human TSH receptor was tested in Chinese Hamster Ovary (CHO) cells (cultured 16 ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetThyrotropin receptor(Homo sapiens (Human))TBA
LigandPNGBDBM60863(US9174940, 33)
Affinity DataIC50: <100nMAssay Description:Antagonist activity of three test compounds against human TSI at the human TSH receptor was tested in Chinese Hamster Ovary (CHO) cells (cultured 16 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetThyrotropin receptor(Homo sapiens (Human))TBA
LigandPNGBDBM60864(US9174940, 34)
Affinity DataIC50: <100nMAssay Description:Antagonist activity of three test compounds against human TSI at the human TSH receptor was tested in Chinese Hamster Ovary (CHO) cells (cultured 16 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetThyrotropin receptor(Homo sapiens (Human))TBA
LigandPNGBDBM60865(US9174940, 35)
Affinity DataIC50: <100nMAssay Description:Antagonist activity of three test compounds against human TSI at the human TSH receptor was tested in Chinese Hamster Ovary (CHO) cells (cultured 16 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetThyrotropin receptor(Homo sapiens (Human))TBA
LigandPNGBDBM60843(US9174940, 1)
Affinity DataIC50: <100nMAssay Description:Antagonist activity of three test compounds against human TSI at the human TSH receptor was tested in Chinese Hamster Ovary (CHO) cells (cultured 16 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetThyrotropin receptor(Homo sapiens (Human))TBA
LigandPNGBDBM60844(US9174940, 4)
Affinity DataIC50: <100nMAssay Description:Antagonist activity of three test compounds against human TSI at the human TSH receptor was tested in Chinese Hamster Ovary (CHO) cells (cultured 16 ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetThyrotropin receptor(Homo sapiens (Human))TBA
LigandPNGBDBM60845(US9174940, 6)
Affinity DataIC50: <100nMAssay Description:Antagonist activity of three test compounds against human TSI at the human TSH receptor was tested in Chinese Hamster Ovary (CHO) cells (cultured 16 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetThyrotropin receptor(Homo sapiens (Human))TBA
LigandPNGBDBM60848(US9174940, 11 | US9174940, 26)
Affinity DataIC50: <100nMAssay Description:Antagonist activity of three test compounds against human TSI at the human TSH receptor was tested in Chinese Hamster Ovary (CHO) cells (cultured 16 ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetThyrotropin receptor(Homo sapiens (Human))TBA
LigandPNGBDBM60847(US9174940, 7)
Affinity DataIC50: <100nMAssay Description:Antagonist activity of three test compounds against human TSI at the human TSH receptor was tested in Chinese Hamster Ovary (CHO) cells (cultured 16 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetThyrotropin receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50614121(CHEMBL5280508)
Affinity DataIC50:  101nMAssay Description:Antagonist activity at human TSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-F...More data for this Ligand-Target Pair
Ligand Info
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TargetThyrotropin receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50614122(CHEMBL5273361)
Affinity DataIC50:  105nMAssay Description:Antagonist activity at human TSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-F...More data for this Ligand-Target Pair
Ligand Info
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TargetThyrotropin receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50614112(CHEMBL5267037)
Affinity DataIC50:  112nMAssay Description:Antagonist activity at human TSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-F...More data for this Ligand-Target Pair
Ligand Info
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