Compile Data Set for Download or QSAR
maximum 50k data
Found 30 Enz. Inhib. hit(s) with all data for entry = 50038000
TargetCytochrome P450 2D6(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50228553(4-(1-(4-(1-cyclobutylpiperidin-4-yloxy)phenyl)-2-o...)
Affinity DataIC50:  4.10E+4nMAssay Description:Inhibition of human CYP2D6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50228552(4-(2-oxo-1-(4-(3-(piperidin-1-yl)propoxy)phenyl)pi...)
Affinity DataIC50:  7.70E+4nMAssay Description:Inhibition of human CYP2D6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50228551(4-(4-fluoro-benzoyl)-1-[4-(3-piperidin-1-yl-propox...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human CYP2D6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50228553(4-(1-(4-(1-cyclobutylpiperidin-4-yloxy)phenyl)-2-o...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human CYP3A4 using 7-benzloxyquinolone substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50228550((R)-4-(2,4-difluorobenzoyl)-1-(4-(3-(2-methylpyrro...)
Affinity DataIC50:  1.00E+5nMAssay Description:Inhibition of human CYP3A4 using 7-benzloxyquinolone substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50228552(4-(2-oxo-1-(4-(3-(piperidin-1-yl)propoxy)phenyl)pi...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human CYP1A2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50228551(4-(4-fluoro-benzoyl)-1-[4-(3-piperidin-1-yl-propox...)
Affinity DataIC50:  1.00E+5nMAssay Description:Inhibition of human CYP3A4 using 7-benzloxyquinolone substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50228552(4-(2-oxo-1-(4-(3-(piperidin-1-yl)propoxy)phenyl)pi...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human CYP2C9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50228550((R)-4-(2,4-difluorobenzoyl)-1-(4-(3-(2-methylpyrro...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human CYP3A4 using diethoxyfluorescein substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50228553(4-(1-(4-(1-cyclobutylpiperidin-4-yloxy)phenyl)-2-o...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human CYP2C19More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50228552(4-(2-oxo-1-(4-(3-(piperidin-1-yl)propoxy)phenyl)pi...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human CYP2C19More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50228550((R)-4-(2,4-difluorobenzoyl)-1-(4-(3-(2-methylpyrro...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human CYP3A4 using 7-{3-(4-phenylpiperazin-1-ylmethyl)benzyl}resorufin substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50228553(4-(1-(4-(1-cyclobutylpiperidin-4-yloxy)phenyl)-2-o...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human CYP3A4 using diethoxyfluorescein substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50228553(4-(1-(4-(1-cyclobutylpiperidin-4-yloxy)phenyl)-2-o...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human CYP2C9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50228551(4-(4-fluoro-benzoyl)-1-[4-(3-piperidin-1-yl-propox...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human CYP2C9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50228550((R)-4-(2,4-difluorobenzoyl)-1-(4-(3-(2-methylpyrro...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human CYP2C9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50228551(4-(4-fluoro-benzoyl)-1-[4-(3-piperidin-1-yl-propox...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human CYP3A4 using diethoxyfluorescein substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50228550((R)-4-(2,4-difluorobenzoyl)-1-(4-(3-(2-methylpyrro...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human CYP2C19More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50228553(4-(1-(4-(1-cyclobutylpiperidin-4-yloxy)phenyl)-2-o...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human CYP1A2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50228550((R)-4-(2,4-difluorobenzoyl)-1-(4-(3-(2-methylpyrro...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human CYP2D6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50228552(4-(2-oxo-1-(4-(3-(piperidin-1-yl)propoxy)phenyl)pi...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human CYP3A4 using 7-{3-(4-phenylpiperazin-1-ylmethyl)benzyl}resorufin substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50228550((R)-4-(2,4-difluorobenzoyl)-1-(4-(3-(2-methylpyrro...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human CYP1A2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50228551(4-(4-fluoro-benzoyl)-1-[4-(3-piperidin-1-yl-propox...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human CYP1A2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50228551(4-(4-fluoro-benzoyl)-1-[4-(3-piperidin-1-yl-propox...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human CYP2C19More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(GUINEA PIG)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50411492(CHEMBL394144)
Affinity DataKd:  2nMAssay Description:Antagonist activity at histamine H3 receptor in guinea pig ileum assessed as inhibition of (R)-methyl histamine induced longitudinal smooth muscle co...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Cavia porcellus (domestic guinea pig))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50228551(4-(4-fluoro-benzoyl)-1-[4-(3-piperidin-1-yl-propox...)
Affinity DataKd: >1.00E+3nMAssay Description:Antagonist activity at histamine H1 receptor in guinea pig ileum assessed as inhibition of histamine-induced longitudinal smooth muscle contractionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Cavia porcellus (domestic guinea pig))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50411492(CHEMBL394144)
Affinity DataKd: >251nMAssay Description:Antagonist activity at histamine H1 receptor in guinea pig ileum assessed as inhibition of histamine-induced longitudinal smooth muscle contractionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(GUINEA PIG)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50228551(4-(4-fluoro-benzoyl)-1-[4-(3-piperidin-1-yl-propox...)
Affinity DataKd:  3.98nMAssay Description:Antagonist activity at histamine H3 receptor in guinea pig ileum assessed as inhibition of (R)-methyl histamine induced longitudinal smooth muscle co...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Cavia porcellus (domestic guinea pig))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50411494(CHEMBL429458)
Affinity DataKd: >1.00E+3nMAssay Description:Antagonist activity at histamine H1 receptor in guinea pig ileum assessed as inhibition of histamine-induced longitudinal smooth muscle contractionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(GUINEA PIG)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50411494(CHEMBL429458)
Affinity DataKd:  1.26nMAssay Description:Antagonist activity at histamine H3 receptor in guinea pig ileum assessed as inhibition of (R)-methyl histamine induced longitudinal smooth muscle co...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed