Compile Data Set for Download or QSAR
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Found 41 Enz. Inhib. hit(s) with all data for entry = 50007842
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM14777((2R,8R)-2-(2H-1,3-benzodioxol-5-yl)-6-methyl-3,6,1...)
Affinity DataIC50:  4nMAssay Description:Inhibition of PDE5A1 (unknown origin) by immobilized metal ion affinity-based fluorescence polarizationMore data for this Ligand-Target Pair
TargetAcetylcholinesterase(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50513221(CHEMBL4455013)
Affinity DataIC50:  4.10nMAssay Description:Inhibition of recombinant human AChE using acetylthiocholine as substrate by UV-visible absorption methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] A(Rattus norvegicus (rat))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50359391(CHEMBL1929421)
Affinity DataIC50:  5.20nMAssay Description:Inhibition of rat liver mitochondrial MAOA [14C]-5-HT as substrate preincubated for 30 mins followed by substrate addition by liquid scintillation co...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50513221(CHEMBL4455013)
Affinity DataIC50:  18nMAssay Description:Inhibition of BACE-1 (unknown origin) after 60 mins by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Rattus norvegicus (rat))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50513220(CHEMBL4435044)
Affinity DataIC50:  32nMAssay Description:Inhibition of AChE from rat cortex by Ellman's methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] B(Rattus norvegicus (rat))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50359391(CHEMBL1929421)
Affinity DataIC50:  43nMAssay Description:Inhibition of rat liver mitochondrial MAOB using [14C]-PEA as substrate preincubated for 30 mins followed by substrate addition by liquid scintillati...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] B(Rattus norvegicus (rat))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50359390(CHEMBL1929418 | CHEMBL2022924)
Affinity DataIC50:  63nMAssay Description:Inhibition of rat liver mitochondrial MAOB using [14C]-PEA as substrate preincubated for 30 mins followed by substrate addition by liquid scintillati...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] A(Rattus norvegicus (rat))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50359390(CHEMBL1929418 | CHEMBL2022924)
Affinity DataIC50:  100nMAssay Description:Inhibition of rat liver mitochondrial MAOA [14C]-5-HT as substrate preincubated for 30 mins followed by substrate addition by liquid scintillation co...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50513223(CHEMBL4467520)
Affinity DataIC50:  195nMAssay Description:Inhibition of AChE (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50359391(CHEMBL1929421)
Affinity DataIC50:  350nMAssay Description:Inhibition of AChE (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50359391(CHEMBL1929421)
Affinity DataIC50:  460nMAssay Description:Inhibition of BACE-1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] A(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50513224(CHEMBL4442213)
Affinity DataIC50:  490nMAssay Description:Irreversible inhibition of MAOA (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCholinesterase(Equus caballus (Horse))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50513226(CHEMBL4475303)
Affinity DataIC50:  520nMAssay Description:Inhibition of equine serum BChE using butyrylthiocholine iodide as substrate preincubated for 10 mins followed by substrate addition by Ellman's meth...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50145909(CHEMBL3763944)
Affinity DataIC50:  900nMAssay Description:Inhibition of GSK3beta (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50513222(CHEMBL4445075)
Affinity DataIC50:  970nMAssay Description:Inhibition of BACE-1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM36551(Chelator, M30 | US9034303, M30)
Affinity DataIC50:  1.50E+3nMAssay Description:Mixed type inhibition of MAOB (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50513224(CHEMBL4442213)
Affinity DataIC50:  1.50E+3nMAssay Description:Inhibition of recombinant human AChEMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50513220(CHEMBL4435044)
Affinity DataIC50:  1.53E+3nMAssay Description:Inhibition of PDE5A1 (unknown origin) by immobilized metal ion affinity-based fluorescence polarizationMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM36551(Chelator, M30 | US9034303, M30)
Affinity DataIC50:  1.60E+3nMAssay Description:Irreversible inhibition of BACE-1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM36551(Chelator, M30 | US9034303, M30)
Affinity DataIC50:  1.80E+3nMAssay Description:Irreversible inhibition of AChE (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50513224(CHEMBL4442213)
Affinity DataIC50:  2.40E+3nMAssay Description:Inhibition of recombinant human BACE-1More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50145909(CHEMBL3763944)
Affinity DataIC50:  2.50E+3nMAssay Description:Inhibition of BACE-1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50513225(CHEMBL4527805)
Affinity DataIC50:  3.44E+3nMAssay Description:Inhibition of human MAOB using benzylamine as substrate preincubated fore 15 mins followed by substrate addition measured after 20 mins by fluorescen...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCarboxylic ester hydrolase(Rattus norvegicus (rat))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50513220(CHEMBL4435044)
Affinity DataIC50:  3.88E+3nMAssay Description:Inhibition of BuChE from rat serum by Ellman's methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50513225(CHEMBL4527805)
Affinity DataIC50:  3.94E+3nMAssay Description:Inhibition of electric eel AChE using acetylthiocholine chloride as substrate preincubated for 15 mins followed by substrate additionMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] A(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM36551(Chelator, M30 | US9034303, M30)
Affinity DataIC50:  6.20E+3nMAssay Description:Irreversible inhibition of MAOA (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50513222(CHEMBL4445075)
Affinity DataIC50:  9.10E+3nMAssay Description:Inhibition of AChE (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM36551(Chelator, M30 | US9034303, M30)
Affinity DataIC50:  1.02E+4nMAssay Description:Irreversible inhibition of MAOB (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2A(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50513223(CHEMBL4467520)
Affinity DataIC50:  1.10E+4nMAssay Description:Inhibition of NMDA receptor (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2A(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50513226(CHEMBL4475303)
Affinity DataIC50:  1.34E+4nMAssay Description:Displacement of [3H]-ifenprodil from NMDA receptor (unknown origin) by scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2A(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50513226(CHEMBL4475303)
Affinity DataIC50:  1.46E+4nMAssay Description:Displacement of [3H]-MK-801 from NMDA receptor (unknown origin) by scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Rattus norvegicus (rat))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM14777((2R,8R)-2-(2H-1,3-benzodioxol-5-yl)-6-methyl-3,6,1...)
Affinity DataIC50:  2.62E+4nMAssay Description:Inhibition of AChE from rat cortex by Ellman's methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50513227(CHEMBL4547969)
Affinity DataIC50:  3.40E+4nMAssay Description:Inhibition of PDE9 catalytic domain (unknown origin) using [3H]cAMP or [3H]cGMP as substrate by liquid scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50513224(CHEMBL4442213)
Affinity DataIC50:  5.39E+4nMAssay Description:Irreversible inhibition of MAOB (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] A(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM36551(Chelator, M30 | US9034303, M30)
Affinity DataIC50:  5.70E+4nMAssay Description:Mixed type inhibition of MAOA (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50435960(CHEMBL2391486)
Affinity DataIC50:  9.20E+4nMAssay Description:Inhibition of electric eel AChE using acetylthiocholine as substrate measured for 3.2 mins by Ellman's methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50513220(CHEMBL4435044)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of PDE3A (unknown origin) by immobilized metal ion affinity-based fluorescence polarizationMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50513220(CHEMBL4435044)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of PDE9A2 (unknown origin) by immobilized metal ion affinity-based fluorescence polarizationMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50513220(CHEMBL4435044)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of PDE2A1 (unknown origin) by immobilized metal ion affinity-based fluorescence polarizationMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50513220(CHEMBL4435044)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of PDE7A (unknown origin) by immobilized metal ion affinity-based fluorescence polarizationMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50513220(CHEMBL4435044)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of PDE6C (unknown origin) by immobilized metal ion affinity-based fluorescence polarizationMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed