Found 7 Enz. Inhib. hit(s) with all data for entry = 50010164 TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
Gilead Sciences
Curated by ChEMBL
Gilead Sciences
Curated by ChEMBL
Affinity DataKi: 0.0200nMAssay Description:Binding affinity to TYK2 pseudokinase domain (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 0.300nMAssay Description:Inhibition of human recombinant GST tagged JAK3 kinase domain (781 to 1124 amino acids) expressed in insect cells in presence of ATPMore data for this Ligand-Target Pair
Affinity DataEC50: 4.30nMAssay Description:Agonist activity at S1P5 (unknown origin) assessed as stimulation of [35S]GTPgammaS binding incubated for 120 mins in presence of GDP by TopCount sci...More data for this Ligand-Target Pair
Affinity DataEC50: 5.40nMAssay Description:Antagonist activity at integrin alpha4beta1 expressed in human Jurkat cells assessed as reduction in cell adhesion to human VCAM-1 incubated for 40 t...More data for this Ligand-Target Pair
Affinity DataEC50: 0.160nMAssay Description:Agonist activity at S1P1 (unknown origin) expressed in CHO-K1 cells using CC4-AM as substrate assessed as inhibition of forskolin-induced cAMP accumu...More data for this Ligand-Target Pair
3D Structure (crystal)TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
Gilead Sciences
Curated by ChEMBL
Gilead Sciences
Curated by ChEMBL
Affinity DataEC50: 13nMAssay Description:Inhibition of TYK2 in human whole blood assessed as reduction in IFN-alpha stimulated TYK2 phosphorylationMore data for this Ligand-Target Pair
Affinity DataEC50: 1.40nMAssay Description:Antagonist activity at integrin alpha4beta7 expressed in human RPMI8866 cells assessed as reduction in cell adhesion to rat MadCAM incubated for 40 t...More data for this Ligand-Target Pair
