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Found 24 Enz. Inhib. hit(s) with all data for entry = 50017372
TargetSerine/threonine-protein kinase PAK 4(Homo sapiens (Human))
National Institute Of Pharmaceutical Education And Research (Niper)

Curated by ChEMBL
LigandPNGBDBM101618(US8530652, 114)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of human PAK4 expressed in TR-293-KDG cells assessed as inhibition of GEFH1 phosphorylation at S180 using GEFH1 as substrate incubated for...More data for this Ligand-Target Pair
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
National Institute Of Pharmaceutical Education And Research (Niper)

Curated by ChEMBL
LigandPNGBDBM50601442(CHEMBL5173625)
Affinity DataIC50:  16nMAssay Description:Inhibition of PDGFR-beta (unknown origin) preincubated for 20 mins followed 33P ATP addition and measured after 120 min by hotspot assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
National Institute Of Pharmaceutical Education And Research (Niper)

Curated by ChEMBL
LigandPNGBDBM50601442(CHEMBL5173625)
Affinity DataIC50:  25nMAssay Description:Inhibition of VEGFR-2 (unknown origin) preincubated for 20 mins followed 33P ATP addition and measured after 120 min by hotspot assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
National Institute Of Pharmaceutical Education And Research (Niper)

Curated by ChEMBL
LigandPNGBDBM50601441(CHEMBL5176427)
Affinity DataIC50:  29nMAssay Description:Inhibition of PDGFR-beta (unknown origin) preincubated for 20 mins followed 33P ATP addition and measured after 120 min by hotspot assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
National Institute Of Pharmaceutical Education And Research (Niper)

Curated by ChEMBL
LigandPNGBDBM50601448(CHEMBL5186025)
Affinity DataIC50:  32nMAssay Description:Inhibition of GSK-3 beta (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
National Institute Of Pharmaceutical Education And Research (Niper)

Curated by ChEMBL
LigandPNGBDBM50601441(CHEMBL5176427)
Affinity DataIC50:  35nMAssay Description:Inhibition of VEGFR-2 (unknown origin) preincubated for 20 mins followed 33P ATP addition and measured after 120 min by hotspot assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetAurora kinase A(Homo sapiens (Human))
National Institute Of Pharmaceutical Education And Research (Niper)

Curated by ChEMBL
LigandPNGBDBM50185000(CHEMBL3823844 | US10351548, Compound SA16)
Affinity DataIC50:  35nMAssay Description:Inhibition of Aurora A (unknown origin) by SelectScreen kinase assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
National Institute Of Pharmaceutical Education And Research (Niper)

Curated by ChEMBL
LigandPNGBDBM50601448(CHEMBL5186025)
Affinity DataIC50:  38nMAssay Description:Inhibition of CDK2 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
National Institute Of Pharmaceutical Education And Research (Niper)

Curated by ChEMBL
LigandPNGBDBM50601449(CHEMBL5172659)
Affinity DataIC50:  40nMAssay Description:Inhibition of GSK-3 beta (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
National Institute Of Pharmaceutical Education And Research (Niper)

Curated by ChEMBL
LigandPNGBDBM50601449(CHEMBL5172659)
Affinity DataIC50:  53nMAssay Description:Inhibition of CDK2 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
National Institute Of Pharmaceutical Education And Research (Niper)

Curated by ChEMBL
LigandPNGBDBM50601444(CHEMBL5173862)
Affinity DataIC50:  120nMAssay Description:Inhibition of EGFR (unknown origin) by colorimetric assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
National Institute Of Pharmaceutical Education And Research (Niper)

Curated by ChEMBL
LigandPNGBDBM50601445(CHEMBL5209100)
Affinity DataIC50:  150nMAssay Description:Inhibition of EGFR (unknown origin) by colorimetric assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
National Institute Of Pharmaceutical Education And Research (Niper)

Curated by ChEMBL
LigandPNGBDBM50601442(CHEMBL5173625)
Affinity DataIC50:  179nMAssay Description:Inhibition of VEGFR-2 (unknown origin) induced tube formation in HUVECs cocultured with fibroblasts measured after 11 days with media renewing every ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
National Institute Of Pharmaceutical Education And Research (Niper)

Curated by ChEMBL
LigandPNGBDBM50601443(CHEMBL5206146)
Affinity DataIC50:  371nMAssay Description:Inhibition of PDGFR beta (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
Target[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial(Homo sapiens (Human))
National Institute Of Pharmaceutical Education And Research (Niper)

Curated by ChEMBL
LigandPNGBDBM50185000(CHEMBL3823844 | US10351548, Compound SA16)
Affinity DataIC50:  416nMAssay Description:Inhibition of PDK1 (unknown origin) by SelectScreen kinase assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
National Institute Of Pharmaceutical Education And Research (Niper)

Curated by ChEMBL
LigandPNGBDBM50601443(CHEMBL5206146)
Affinity DataIC50:  435nMAssay Description:Inhibition of VEGFR-2 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
National Institute Of Pharmaceutical Education And Research (Niper)

Curated by ChEMBL
LigandPNGBDBM50601447(CHEMBL5196783)
Affinity DataIC50:  460nMAssay Description:Inhibition of BCL2 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetSerine/threonine-protein kinase PAK 4(Homo sapiens (Human))
National Institute Of Pharmaceutical Education And Research (Niper)

Curated by ChEMBL
LigandPNGBDBM4814(CHEMBL535 | N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fl...)
Affinity DataIC50:  569nMAssay Description:Inhibition of PAK4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
National Institute Of Pharmaceutical Education And Research (Niper)

Curated by ChEMBL
LigandPNGBDBM50601443(CHEMBL5206146)
Affinity DataIC50:  654nMAssay Description:Inhibition of c-Met (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
National Institute Of Pharmaceutical Education And Research (Niper)

Curated by ChEMBL
LigandPNGBDBM50601447(CHEMBL5196783)
Affinity DataIC50:  850nMAssay Description:Inhibition of CDK2 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCyclin-dependent kinase 4(Homo sapiens (Human))
National Institute Of Pharmaceutical Education And Research (Niper)

Curated by ChEMBL
LigandPNGBDBM50601446(CHEMBL5170178)
Affinity DataIC50:  1.26E+3nMAssay Description:Inhibition of CDK4 (unknown origin) by HotSpotM assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
National Institute Of Pharmaceutical Education And Research (Niper)

Curated by ChEMBL
LigandPNGBDBM50601450(CHEMBL5178027)
Affinity DataIC50:  5.00E+3nMAssay Description:Inhibition of PIM1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
Target[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial(Homo sapiens (Human))
National Institute Of Pharmaceutical Education And Research (Niper)

Curated by ChEMBL
LigandPNGBDBM50499153(CHEMBL3091673)
Affinity DataIC50:  9.80E+4nMAssay Description:Inhibition of PDK1 (unknown origin) by SelectScreen kinase assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetSerine/threonine-protein kinase PAK 4(Homo sapiens (Human))
National Institute Of Pharmaceutical Education And Research (Niper)

Curated by ChEMBL
LigandPNGBDBM101618(US8530652, 114)
Affinity DataKd:  2.70nMAssay Description:Binding affinity to human PAK4 (300 to 591 residues) assessed as dissociation constant by isothermal calorimetric analysisMore data for this Ligand-Target Pair