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Found 59 Enz. Inhib. hit(s) with all data for entry = 50017855
TargetDual specificity mitogen-activated protein kinase kinase 5(Homo sapiens (Human))
Newcastle University Centre For Cancer

Curated by ChEMBL
LigandPNGBDBM50434072(CHEMBL2381342)
Affinity DataIC50:  1.5nMAssay Description:Inhibition of MEK5 (unknown origin) expressed in baculovirus expression system incubated for 90 mins in presence of ATP by PKlight ATP detection reag...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetMitogen-activated protein kinase 7(Homo sapiens (Human))
Newcastle University Centre For Cancer

Curated by ChEMBL
LigandPNGBDBM50605526(CHEMBL5188920)
Affinity DataIC50:  5nMAssay Description:Inhibition of ERK5 (unknown origin) using K-5FAM-LVEPLTPSGEAPNQ-COOH as substrate incubated for 2 hrs in presence of ATP by IMAP-FP assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMitogen-activated protein kinase 7(Homo sapiens (Human))
Newcastle University Centre For Cancer

Curated by ChEMBL
LigandPNGBDBM50605525(CHEMBL5175191)
Affinity DataIC50:  5nMAssay Description:Inhibition of ERK5 (unknown origin) using K-5FAM-LVEPLTPSGEAPNQ-COOH as substrate incubated for 2 hrs in presence of ATP by IMAP-FP assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMitogen-activated protein kinase 7(Homo sapiens (Human))
Newcastle University Centre For Cancer

Curated by ChEMBL
LigandPNGBDBM50605527(CHEMBL5186248)
Affinity DataIC50:  6nMAssay Description:Inhibition of ERK5 (unknown origin) using K-5FAM-LVEPLTPSGEAPNQ-COOH as substrate incubated for 2 hrs in presence of ATP by IMAP-FP assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetMitogen-activated protein kinase 7(Homo sapiens (Human))
Newcastle University Centre For Cancer

Curated by ChEMBL
LigandPNGBDBM50605535(CHEMBL5198962)
Affinity DataIC50:  7nMAssay Description:Inhibition of ERK5 (unknown origin) using K-5FAM-LVEPLTPSGEAPNQ-COOH as substrate incubated for 2 hrs in presence of ATP by IMAP-FP assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMitogen-activated protein kinase 7(Homo sapiens (Human))
Newcastle University Centre For Cancer

Curated by ChEMBL
LigandPNGBDBM50605523(CHEMBL5197199)
Affinity DataIC50:  7nMAssay Description:Inhibition of ERK5 (unknown origin) using K-5FAM-LVEPLTPSGEAPNQ-COOH as substrate incubated for 2 hrs in presence of ATP by IMAP-FP assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMitogen-activated protein kinase 7(Homo sapiens (Human))
Newcastle University Centre For Cancer

Curated by ChEMBL
LigandPNGBDBM50508013(CHEMBL4541479)
Affinity DataIC50:  8nMAssay Description:Inhibition of ERK5 (unknown origin) incubated for 1 hr by KiNativ profiling analysisMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetMitogen-activated protein kinase 7(Homo sapiens (Human))
Newcastle University Centre For Cancer

Curated by ChEMBL
LigandPNGBDBM50605522(CHEMBL5172952)
Affinity DataIC50:  8nMAssay Description:Inhibition of ERK5 (unknown origin) using K-5FAM-LVEPLTPSGEAPNQ-COOH as substrate incubated for 2 hrs in presence of ATP by IMAP-FP assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMitogen-activated protein kinase 7(Homo sapiens (Human))
Newcastle University Centre For Cancer

Curated by ChEMBL
LigandPNGBDBM50605519(CHEMBL5175007)
Affinity DataIC50:  13nMAssay Description:Inhibition of ERK5 (unknown origin) using K-5FAM-LVEPLTPSGEAPNQ-COOH as substrate incubated for 2 hrs in presence of ATP by IMAP-FP assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMitogen-activated protein kinase 7(Homo sapiens (Human))
Newcastle University Centre For Cancer

Curated by ChEMBL
LigandPNGBDBM50605520(CHEMBL5202924)
Affinity DataIC50:  13nMAssay Description:Inhibition of ERK5 (unknown origin) using K-5FAM-LVEPLTPSGEAPNQ-COOH as substrate incubated for 2 hrs in presence of ATP by IMAP-FP assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMitogen-activated protein kinase 7(Homo sapiens (Human))
Newcastle University Centre For Cancer

Curated by ChEMBL
LigandPNGBDBM50605521(CHEMBL5173346)
Affinity DataIC50:  14nMAssay Description:Inhibition of ERK5 (unknown origin) using K-5FAM-LVEPLTPSGEAPNQ-COOH as substrate incubated for 2 hrs in presence of ATP by IMAP-FP assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMitogen-activated protein kinase 7(Homo sapiens (Human))
Newcastle University Centre For Cancer

Curated by ChEMBL
LigandPNGBDBM50605528(CHEMBL5175760)
Affinity DataIC50:  14nMAssay Description:Inhibition of ERK5 (unknown origin) using K-5FAM-LVEPLTPSGEAPNQ-COOH as substrate incubated for 2 hrs in presence of ATP by IMAP-FP assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMitogen-activated protein kinase 7(Homo sapiens (Human))
Newcastle University Centre For Cancer

Curated by ChEMBL
LigandPNGBDBM50605536(CHEMBL5208879)
Affinity DataIC50:  16nMAssay Description:Inhibition of ERK5 (unknown origin) using K-5FAM-LVEPLTPSGEAPNQ-COOH as substrate incubated for 2 hrs in presence of ATP by IMAP-FP assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMitogen-activated protein kinase 7(Homo sapiens (Human))
Newcastle University Centre For Cancer

Curated by ChEMBL
LigandPNGBDBM50605533(CHEMBL5180089)
Affinity DataIC50:  19nMAssay Description:Inhibition of ERK5 (unknown origin) using K-5FAM-LVEPLTPSGEAPNQ-COOH as substrate incubated for 2 hrs in presence of ATP by IMAP-FP assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMitogen-activated protein kinase 7(Homo sapiens (Human))
Newcastle University Centre For Cancer

Curated by ChEMBL
LigandPNGBDBM50605523(CHEMBL5197199)
Affinity DataIC50:  20nMAssay Description:Inhibition of ERK5 phosphorylation in human HeLa cells incubated for 1 hr by Western blot densitometry analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMitogen-activated protein kinase 7(Homo sapiens (Human))
Newcastle University Centre For Cancer

Curated by ChEMBL
LigandPNGBDBM50605534(CHEMBL5208123)
Affinity DataIC50:  22nMAssay Description:Inhibition of ERK5 (unknown origin) using K-5FAM-LVEPLTPSGEAPNQ-COOH as substrate incubated for 2 hrs in presence of ATP by IMAP-FP assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMitogen-activated protein kinase 7(Homo sapiens (Human))
Newcastle University Centre For Cancer

Curated by ChEMBL
LigandPNGBDBM50605524(CHEMBL5193573)
Affinity DataIC50:  25nMAssay Description:Inhibition of ERK5 (unknown origin) using K-5FAM-LVEPLTPSGEAPNQ-COOH as substrate incubated for 2 hrs in presence of ATP by IMAP-FP assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMitogen-activated protein kinase 7(Homo sapiens (Human))
Newcastle University Centre For Cancer

Curated by ChEMBL
LigandPNGBDBM50605527(CHEMBL5186248)
Affinity DataIC50:  31nMAssay Description:Inhibition of ERK5 phosphorylation in human HeLa cells incubated for 1 hr by Western blot densitometry analysisMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetMitogen-activated protein kinase 7(Homo sapiens (Human))
Newcastle University Centre For Cancer

Curated by ChEMBL
LigandPNGBDBM50507989(CHEMBL4445670)
Affinity DataIC50:  35nMAssay Description:Inhibition of human recombinant N-terminal GST-tagged ERK5 (1 to 398 residues) expressed in Escherichia coli using biotinylated peptide Ahx-PPGDYSTTP...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetMitogen-activated protein kinase 7(Homo sapiens (Human))
Newcastle University Centre For Cancer

Curated by ChEMBL
LigandPNGBDBM50605518(CHEMBL5179461)
Affinity DataIC50:  37nMAssay Description:Inhibition of ERK5 (unknown origin) using K-5FAM-LVEPLTPSGEAPNQ-COOH as substrate incubated for 2 hrs in presence of ATP by IMAP-FP assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMitogen-activated protein kinase 7(Homo sapiens (Human))
Newcastle University Centre For Cancer

Curated by ChEMBL
LigandPNGBDBM50605521(CHEMBL5173346)
Affinity DataIC50:  43nMAssay Description:Inhibition of ERK5 phosphorylation in human HeLa cells incubated for 1 hr by Western blot densitometry analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMitogen-activated protein kinase 7(Homo sapiens (Human))
Newcastle University Centre For Cancer

Curated by ChEMBL
LigandPNGBDBM50605528(CHEMBL5175760)
Affinity DataIC50:  58nMAssay Description:Inhibition of ERK5 phosphorylation in human HeLa cells incubated for 1 hr by Western blot densitometry analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMitogen-activated protein kinase 7(Homo sapiens (Human))
Newcastle University Centre For Cancer

Curated by ChEMBL
LigandPNGBDBM50434072(CHEMBL2381342)
Affinity DataIC50:  59nMAssay Description:Inhibition of ERK5 (unknown origin) expressed in baculovirus expression system incubated for 90 mins in presence of ATP by PKlight ATP detection reag...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetMitogen-activated protein kinase 7(Homo sapiens (Human))
Newcastle University Centre For Cancer

Curated by ChEMBL
LigandPNGBDBM50605522(CHEMBL5172952)
Affinity DataIC50:  60nMAssay Description:Inhibition of ERK5 phosphorylation in human HeLa cells incubated for 1 hr by Western blot densitometry analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMitogen-activated protein kinase 7(Homo sapiens (Human))
Newcastle University Centre For Cancer

Curated by ChEMBL
LigandPNGBDBM50605526(CHEMBL5188920)
Affinity DataIC50:  70nMAssay Description:Inhibition of ERK5 phosphorylation in human HeLa cells incubated for 1 hr by Western blot densitometry analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMitogen-activated protein kinase 7(Homo sapiens (Human))
Newcastle University Centre For Cancer

Curated by ChEMBL
LigandPNGBDBM50605517(CHEMBL5209433)
Affinity DataIC50:  72nMAssay Description:Inhibition of ERK5 (unknown origin) using K-5FAM-LVEPLTPSGEAPNQ-COOH as substrate incubated for 2 hrs in presence of ATP by IMAP-FP assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMitogen-activated protein kinase 7(Homo sapiens (Human))
Newcastle University Centre For Cancer

Curated by ChEMBL
LigandPNGBDBM50605511(CHEMBL5193786)
Affinity DataIC50:  77nMAssay Description:Inhibition of ERK5 (1 to 492 residues) in HEK293 cells assessed as paradoxical activation of ERK5 transcriptional activity incubated for 20 hrs by du...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetMitogen-activated protein kinase 7(Homo sapiens (Human))
Newcastle University Centre For Cancer

Curated by ChEMBL
LigandPNGBDBM50605511(CHEMBL5193786)
Affinity DataIC50:  79nMAssay Description:Inhibition of ERK5 (unknown origin) using K-5FAM-LVEPLTPSGEAPNQ-COOH as substrate incubated for 2 hrs in presence of ATP by IMAP-FP assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetMitogen-activated protein kinase 7(Homo sapiens (Human))
Newcastle University Centre For Cancer

Curated by ChEMBL
LigandPNGBDBM50605529(CHEMBL5171050)
Affinity DataIC50:  99nMAssay Description:Inhibition of ERK5 (unknown origin) using K-5FAM-LVEPLTPSGEAPNQ-COOH as substrate incubated for 2 hrs in presence of ATP by IMAP-FP assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMitogen-activated protein kinase 7(Homo sapiens (Human))
Newcastle University Centre For Cancer

Curated by ChEMBL
LigandPNGBDBM50605511(CHEMBL5193786)
Affinity DataIC50:  141nMAssay Description:Inhibition of ERK5 phosphorylation in human HeLa cells incubated for 1 hr by Western blot densitometry analysisMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetMitogen-activated protein kinase 7(Homo sapiens (Human))
Newcastle University Centre For Cancer

Curated by ChEMBL
LigandPNGBDBM50605512(CHEMBL5175353)
Affinity DataIC50:  400nMAssay Description:Inhibition of ERK5 (unknown origin) using K-5FAM-LVEPLTPSGEAPNQ-COOH as substrate incubated for 2 hrs in presence of ATP by IMAP-FP assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMitogen-activated protein kinase 7(Homo sapiens (Human))
Newcastle University Centre For Cancer

Curated by ChEMBL
LigandPNGBDBM50605532(CHEMBL5194814)
Affinity DataIC50:  642nMAssay Description:Inhibition of ERK5 (unknown origin) using K-5FAM-LVEPLTPSGEAPNQ-COOH as substrate incubated for 2 hrs in presence of ATP by IMAP-FP assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMitogen-activated protein kinase 7(Homo sapiens (Human))
Newcastle University Centre For Cancer

Curated by ChEMBL
LigandPNGBDBM50605535(CHEMBL5198962)
Affinity DataIC50:  671nMAssay Description:Inhibition of ERK5 phosphorylation in human HeLa cells incubated for 1 hr by Western blot densitometry analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMitogen-activated protein kinase 7(Homo sapiens (Human))
Newcastle University Centre For Cancer

Curated by ChEMBL
LigandPNGBDBM50516388(CHEMBL4453232)
Affinity DataIC50:  700nMAssay Description:Inhibition of human recombinant N-terminal His-tagged / TEV cleavage site fused ERK5 (2 to 409 residues) expressed in baculovirus infected Sf9 cells ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMitogen-activated protein kinase 7(Homo sapiens (Human))
Newcastle University Centre For Cancer

Curated by ChEMBL
LigandPNGBDBM50605533(CHEMBL5180089)
Affinity DataIC50:  787nMAssay Description:Inhibition of ERK5 phosphorylation in human HeLa cells incubated for 1 hr by Western blot densitometry analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMitogen-activated protein kinase 7(Homo sapiens (Human))
Newcastle University Centre For Cancer

Curated by ChEMBL
LigandPNGBDBM50605514(CHEMBL5176592)
Affinity DataIC50:  790nMAssay Description:Inhibition of ERK5 (unknown origin) using K-5FAM-LVEPLTPSGEAPNQ-COOH as substrate incubated for 2 hrs in presence of ATP by IMAP-FP assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMitogen-activated protein kinase 7(Homo sapiens (Human))
Newcastle University Centre For Cancer

Curated by ChEMBL
LigandPNGBDBM50516382(CHEMBL4436895)
Affinity DataIC50:  820nMAssay Description:Inhibition of human recombinant N-terminal His-tagged / TEV cleavage site fused ERK5 (2 to 409 residues) expressed in baculovirus infected Sf9 cells ...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 7(Homo sapiens (Human))
Newcastle University Centre For Cancer

Curated by ChEMBL
LigandPNGBDBM50605511(CHEMBL5193786)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of full-length ERK5 in HEK293 cells assessed as paradoxical activation of ERK5 transcriptional activity incubated for 20 hrs by dual lucif...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetMitogen-activated protein kinase 7(Homo sapiens (Human))
Newcastle University Centre For Cancer

Curated by ChEMBL
LigandPNGBDBM50605530(CHEMBL5179069)
Affinity DataIC50:  1.04E+3nMAssay Description:Inhibition of ERK5 (unknown origin) using K-5FAM-LVEPLTPSGEAPNQ-COOH as substrate incubated for 2 hrs in presence of ATP by IMAP-FP assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMitogen-activated protein kinase 7(Homo sapiens (Human))
Newcastle University Centre For Cancer

Curated by ChEMBL
LigandPNGBDBM50605513(CHEMBL5192101)
Affinity DataIC50:  1.20E+3nMAssay Description:Inhibition of ERK5 (unknown origin) using K-5FAM-LVEPLTPSGEAPNQ-COOH as substrate incubated for 2 hrs in presence of ATP by IMAP-FP assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMitogen-activated protein kinase 7(Homo sapiens (Human))
Newcastle University Centre For Cancer

Curated by ChEMBL
LigandPNGBDBM50605531(CHEMBL5204421)
Affinity DataIC50:  1.24E+3nMAssay Description:Inhibition of ERK5 (unknown origin) using K-5FAM-LVEPLTPSGEAPNQ-COOH as substrate incubated for 2 hrs in presence of ATP by IMAP-FP assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMitogen-activated protein kinase 7(Homo sapiens (Human))
Newcastle University Centre For Cancer

Curated by ChEMBL
LigandPNGBDBM50605516(CHEMBL5181376)
Affinity DataIC50:  2.10E+3nMAssay Description:Inhibition of ERK5 (unknown origin) using K-5FAM-LVEPLTPSGEAPNQ-COOH as substrate incubated for 2 hrs in presence of ATP by IMAP-FP assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Newcastle University Centre For Cancer

Curated by ChEMBL
LigandPNGBDBM50605518(CHEMBL5179461)
Affinity DataIC50:  2.63E+3nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMitogen-activated protein kinase 7(Homo sapiens (Human))
Newcastle University Centre For Cancer

Curated by ChEMBL
LigandPNGBDBM50605515(CHEMBL5207370)
Affinity DataIC50:  3.50E+3nMAssay Description:Inhibition of ERK5 (unknown origin) using K-5FAM-LVEPLTPSGEAPNQ-COOH as substrate incubated for 2 hrs in presence of ATP by IMAP-FP assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Newcastle University Centre For Cancer

Curated by ChEMBL
LigandPNGBDBM50605511(CHEMBL5193786)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of BRD4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Newcastle University Centre For Cancer

Curated by ChEMBL
LigandPNGBDBM50605519(CHEMBL5175007)
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Newcastle University Centre For Cancer

Curated by ChEMBL
LigandPNGBDBM50605520(CHEMBL5202924)
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMitogen-activated protein kinase 11/12/13/14(Homo sapiens (Human))
Newcastle University Centre For Cancer

Curated by ChEMBL
LigandPNGBDBM50605511(CHEMBL5193786)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of P38 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Newcastle University Centre For Cancer

Curated by ChEMBL
LigandPNGBDBM50605511(CHEMBL5193786)
Affinity DataKd:  1.30nMAssay Description:Binding affinity to wild type human partial length JAK3 (I781 to S1124 residues) expressed in mammalian expression system by Kinomescan binding assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Newcastle University Centre For Cancer

Curated by ChEMBL
LigandPNGBDBM50508013(CHEMBL4541479)
Affinity DataKd:  3.60E+3nMAssay Description:Binding affinity to human BRD4 BD1 (44 to 168 residues) expressed in bacterial expression system by bromoscan assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
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