Reaction Details Report a problem with these data
Target
Casein kinase II subunit alpha
Ligand
BDBM11315
Substrate
CK-2 Peptide Substrate
Meas. Tech.
Kinase Inhibition Assay
pH
7.5±n/a
Temperature
295.15±n/a K
Ki
350±n/a nM
Citation
 De Moliner, E; Moro, S; Sarno, S; Zagotto, G; Zanotti, G; Pinna, LA; Battistutta, R Inhibition of protein kinase CK2 by anthraquinone-related compounds. A structural insight. J Biol Chem 278:1831-6 (2003) [PubMed]  Article 
Target
Name:
Casein kinase II subunit alpha
Synonyms:
ACK2 | CK II | CK2- alpha | CSK2A_MAIZE | Casein Kinase II
Type:
Enzyme
Mol. Mass.:
39238.74
Organism:
Zea mays (Maize)
Description:
n/a
Residue:
332
Sequence:
MSKARVYADVNVLRPKEYWDYEALTVQWGEQDDYEVVRKVGRGKYSEVFEGINVNNNEKCIIKILKPVKKKKIKREIKILQNLCGGPNIVKLLDIVRDQHSKTPSLIFEYVNNTDFKVLYPTLTDYDIRYYIYELLKALDYCHSQGIMHRDVKPHNVMIDHELRKLRLIDWGLAEFYHPGKEYNVRVASRYFKGPELLVDLQDYDYSLDMWSLGCMFAGMIFRKEPFFYGHDNHDQLVKIAKVLGTDGLNVYLNKYRIELDPQLEALVGRHSRKPWLKFMNADNQHLVSPEAIDFLDKLLRYDHQERLTALEAMTHPYFQQVRAAENSRTRA
  
Inhibitor
Name:
BDBM11315
Synonyms:
1,4-diamino-5,8-dihydroxy-9,10-dihydroanthracene-9,10-dione | 1,4-diamino-5,8-dihydroxy-anthraquinone | DAA
Type:
Small organic molecule
Emp. Form.:
C14H10N2O4
Mol. Mass.:
270.2402
SMILES:
Nc1ccc(N)c2C(=O)c3c(O)ccc(O)c3C(=O)c12
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
CK-2 Peptide Substrate
Synonyms:
n/a
Type:
Peptide
Mol. Mass.:
1446.31
Organism:
n/a
Description:
n/a
Residue:
12
Sequence:
RRRADDSDDDDD