Reaction Details Report a problem with these data
Target
Sigma non-opioid intracellular receptor 1
Ligand
BDBM50321768
Substrate
n/a
Meas. Tech.
ChEBML_1685095
Ki
9.0±n/a nM
Citation
 Knappmann, I; Lehmkuhl, K; Köhler, J; Schepmann, D; Giera, M; Bracher, F; Wünsch, B Lipase-catalyzed kinetic resolution as key step in the synthesis of enantiomerically pure? ligands with 2-benzopyran structure. Bioorg Med Chem 25:3384-3395 (2017) [PubMed]  Article 
Target
Name:
Sigma non-opioid intracellular receptor 1
Synonyms:
OPRS1 | SGMR1_CAVPO | SIGMAR1 | Sigma 1-type opioid receptor | Sigma non-opioid intracellular receptor 1 | Sigma-1 receptor | Sigma1-receptor | Sigma1R | Sterol isomerase-like protein
Type:
Protein
Mol. Mass.:
25307.17
Organism:
Cavia porcellus (Guinea pig)
Description:
Q60492
Residue:
223
Sequence:
MQWAVGRRWLWVALFLAAVAVLTQIVWLWLGTQNFVFQREEIAQLARQYAGLDHELAFSKLIVELRRLHPVHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSPRHSGRYWAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLGFALADTVFSTQDFLTLFYTLRVYARALQLELTTYLFGQDP
  
Inhibitor
Name:
BDBM50321768
Synonyms:
(S)-2-(1'-(cyclohexylmethyl)spiro[isochroman-1,4'-piperidine]-3-yl)ethanol | CHEMBL1172685
Type:
Small organic molecule
Emp. Form.:
C22H33NO2
Mol. Mass.:
343.5029
SMILES:
OCC[C@@H]1Cc2ccccc2C2(CCN(CC3CCCCC3)CC2)O1 |r|
Structure:
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