Reaction Details Report a problem with these data
Target
Sigma non-opioid intracellular receptor 1
Ligand
BDBM50252685
Substrate
n/a
Meas. Tech.
ChEBML_1685095
Ki
2.3±n/a nM
Citation
 Knappmann, I; Lehmkuhl, K; Köhler, J; Schepmann, D; Giera, M; Bracher, F; Wünsch, B Lipase-catalyzed kinetic resolution as key step in the synthesis of enantiomerically pure? ligands with 2-benzopyran structure. Bioorg Med Chem 25:3384-3395 (2017) [PubMed]  Article 
Target
Name:
Sigma non-opioid intracellular receptor 1
Synonyms:
OPRS1 | SGMR1_CAVPO | SIGMAR1 | Sigma 1-type opioid receptor | Sigma non-opioid intracellular receptor 1 | Sigma-1 receptor | Sigma1-receptor | Sigma1R | Sterol isomerase-like protein
Type:
Protein
Mol. Mass.:
25307.17
Organism:
Cavia porcellus (Guinea pig)
Description:
Q60492
Residue:
223
Sequence:
MQWAVGRRWLWVALFLAAVAVLTQIVWLWLGTQNFVFQREEIAQLARQYAGLDHELAFSKLIVELRRLHPVHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSPRHSGRYWAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLGFALADTVFSTQDFLTLFYTLRVYARALQLELTTYLFGQDP
  
Inhibitor
Name:
BDBM50252685
Synonyms:
CHEMBL4064375
Type:
Small organic molecule
Emp. Form.:
C21H24FNO
Mol. Mass.:
325.4198
SMILES:
FCC[C@@H]1OC2(CCN(Cc3ccccc3)CC2)c2ccccc12 |r|
Structure:
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