Reaction Details Report a problem with these data
Target
Sigma non-opioid intracellular receptor 1
Ligand
BDBM50260580
Substrate
n/a
Meas. Tech.
ChEBML_1694030
Ki
5.0±n/a nM
Citation
 Fanter, L; Müller, C; Schepmann, D; Bracher, F; Wünsch, B Chiral-pool synthesis of 1,2,4-trisubstituted 1,4-diazepanes as novel? Bioorg Med Chem 25:4778-4799 (2017) [PubMed]  Article 
Target
Name:
Sigma non-opioid intracellular receptor 1
Synonyms:
OPRS1 | SGMR1_CAVPO | SIGMAR1 | Sigma 1-type opioid receptor | Sigma non-opioid intracellular receptor 1 | Sigma-1 receptor | Sigma1-receptor | Sigma1R | Sterol isomerase-like protein
Type:
Protein
Mol. Mass.:
25307.17
Organism:
Cavia porcellus (Guinea pig)
Description:
Q60492
Residue:
223
Sequence:
MQWAVGRRWLWVALFLAAVAVLTQIVWLWLGTQNFVFQREEIAQLARQYAGLDHELAFSKLIVELRRLHPVHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSPRHSGRYWAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLGFALADTVFSTQDFLTLFYTLRVYARALQLELTTYLFGQDP
  
Inhibitor
Name:
BDBM50260580
Synonyms:
CHEMBL4098070
Type:
Small organic molecule
Emp. Form.:
C24H32N2
Mol. Mass.:
348.5243
SMILES:
[#6]\[#6](-[#6])=[#6]\[#6]-[#7]-1-[#6]-[#6]-[#6]-[#7](-[#6]-c2ccccc2)-[#6@H](-[#6]-c2ccccc2)-[#6]-1 |r|
Structure:
Search PDB for entries with ligand similarity: