Reaction Details Report a problem with these data
Target
Sigma intracellular receptor 2
Ligand
BDBM50456609
Substrate
n/a
Meas. Tech.
ChEMBL_1757530 (CHEMBL4192538)
Ki
>10000±n/a nM
Citation
 Dey, S; Temme, L; Schreiber, JA; Schepmann, D; Frehland, B; Lehmkuhl, K; Strutz-Seebohm, N; Seebohm, G; Wünsch, B Deconstruction - reconstruction approach to analyze the essential structural elements of tetrahydro-3-benzazepine-based antagonists of GluN2B subunit containing NMDA receptors. Eur J Med Chem 138:552-564 (2017) [PubMed]  Article 
Target
Name:
Sigma intracellular receptor 2
Synonyms:
S2r | SGMR2_RAT | Sigma intracellular receptor 2 | Sigma-2 receptor | Sigma2 receptor | Tmem97 | Transmembrane protein 97
Type:
Protein
Mol. Mass.:
20953.88
Organism:
Rattus norvegicus (Rat)
Description:
Q5U3Y7
Residue:
176
Sequence:
MGAVTARRCVEWLLGLYFVSHIPITMFIDLQALLPPELYPQEFSNLLRWYSKEFKDPLMQEPPVWFKSFLFCELVFQLPFFPIAAYAFFKGSCRWIRIPAIIYAVHTITTLIPILYTILFEDFSKAIAFKGQRPENFRERLTLVGVYAPYLIIPLILLLFMLRNPYYKFEEKRKKK
  
Inhibitor
Name:
BDBM50456609
Synonyms:
CHEMBL4215740
Type:
Small organic molecule
Emp. Form.:
C18H20N2O3
Mol. Mass.:
312.363
SMILES:
OC1CN(CCc2ccccc2)CCc2ccc(cc12)[N+]([O-])=O
Structure:
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