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Target
DCN1-like protein 1
Ligand
BDBM50460801
Substrate
n/a
Meas. Tech.
ChEMBL_1770432 (CHEMBL4222544)
IC50
7600±n/a nM
Citation
 Hammill, JT; Scott, DC; Min, J; Connelly, MC; Holbrook, G; Zhu, F; Matheny, A; Yang, L; Singh, B; Schulman, BA; Guy, RK Piperidinyl Ureas Chemically Control Defective in Cullin Neddylation 1 (DCN1)-Mediated Cullin Neddylation. J Med Chem 61:2680-2693 (2018) [PubMed]  Article 
Target
Name:
DCN1-like protein 1
Synonyms:
DCN1 | DCN1-like protein 1 | DCNL1_HUMAN | DCUN1 domain-containing protein 1 | DCUN1D1 | DCUN1L1 | Defective in cullin neddylation protein 1-like protein 1 | RP42 | SCCRO | Squamous cell carcinoma-related oncogene | Synonyms=DCN1
Type:
PROTEIN
Mol. Mass.:
30118.96
Organism:
Homo sapiens
Description:
ChEMBL_117443
Residue:
259
Sequence:
MNKLKSSQKDKVRQFMIFTQSSEKTAVSCLSQNDWKLDVATDNFFQNPELYIRESVKGSLDRKKLEQLYNRYKDPQDENKIGIDGIQQFCDDLALDPASISVLIIAWKFRAATQCEFSKQEFMDGMTELGCDSIEKLKAQIPKMEQELKEPGRFKDFYQFTFNFAKNPGQKGLDLEMAIAYWNLVLNGRFKFLDLWNKFLLEHHKRSIPKDTWNLLLDFSTMIADDMSNYDEEGAWPVLIDDFVEFARPQIAGTKSTTV
  
Inhibitor
Name:
BDBM50460801
Synonyms:
CHEMBL4086524 | US11116757, No. Table11.10
Type:
Small organic molecule
Emp. Form.:
C20H22F3N3O
Mol. Mass.:
377.4034
SMILES:
FC(F)(F)c1cccc(NC(=O)NC2CCN(Cc3ccccc3)CC2)c1
Structure:
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