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Target
Type-2 angiotensin II receptor
Ligand
BDBM50549531
Substrate
n/a
Meas. Tech.
ChEMBL_2025178 (CHEMBL4678991)
Ki
110±n/a nM
Citation
 Wannberg, J; Gising, J; Lindman, J; Salander, J; Gutiérrez-de-Terán, H; Ablahad, H; Hamid, S; Grönbladh, A; Spizzo, I; Gaspari, TA; Widdop, RE; Hallberg, A; Backlund, M; Le?niak, A; Hallberg, M; Larhed, M N-(Methyloxycarbonyl)thiophene sulfonamides as high affinity AT2 receptor ligands. Bioorg Med Chem 29:0 (2021) [PubMed]  Article 
Target
Name:
Type-2 angiotensin II receptor
Synonyms:
AGTR2 | AGTR2_HUMAN | AT2 | Angiotensin II receptor | Angiotensin II type 2 (AT-2) receptor | Angiotensin II, central | Type-2 angiotensin II receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
41201.61
Organism:
Homo sapiens (Human)
Description:
Angiotensin II, central 0 0::P50052
Residue:
363
Sequence:
MKGNSTLATTSKNITSGLHFGLVNISGNNESTLNCSQKPSDKHLDAIPILYYIIFVIGFLVNIVVVTLFCCQKGPKKVSSIYIFNLAVADLLLLATLPLWATYYSYRYDWLFGPVMCKVFGSFLTLNMFASIFFITCMSVDRYQSVIYPFLSQRRNPWQASYIVPLVWCMACLSSLPTFYFRDVRTIEYLGVNACIMAFPPEKYAQWSAGIALMKNILGFIIPLIFIATCYFGIRKHLLKTNSYGKNRITRDQVLKMAAAVVLAFIICWLPFHVLTFLDALAWMGVINSCEVIAVIDLALPFAILLGFTNSCVNPFLYCFVGNRFQQKLRSVFRVPITWLQGKRESMSCRKSSSLREMETFVS
  
Inhibitor
Name:
BDBM50549531
Synonyms:
CHEMBL4762752
Type:
Small organic molecule
Emp. Form.:
C24H27N3O5S2
Mol. Mass.:
501.618
SMILES:
COC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(c1)C(=O)Cn1ccnc1C1CC1
Structure:
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