Reaction Details Report a problem with these data
Target
Protein arginine N-methyltransferase 6
Ligand
BDBM50580051
Substrate
n/a
Meas. Tech.
ChEMBL_2146479 (CHEMBL5030825)
IC50
600±n/a nM
Citation
 Shen, Y; Li, F; Szewczyk, MM; Halabelian, L; Chau, I; Eram, MS; Dela Seña, C; Park, KS; Meng, F; Chen, H; Zeng, H; Dong, A; Wu, H; Trush, VV; McLeod, D; Zepeda-Velázquez, CA; Campbell, RM; Mader, MM; Watson, BM; Schapira, M; Arrowsmith, CH; Al-Awar, R; Barsyte-Lovejoy, D; Kaniskan, HÜ; Brown, PJ; Vedadi, M; Jin, J A First-in-Class, Highly Selective and Cell-Active Allosteric Inhibitor of Protein Arginine Methyltransferase 6. J Med Chem 64:3697-3706 (2021) [PubMed]  Article 
Target
Name:
Protein arginine N-methyltransferase 6
Synonyms:
ANM6_HUMAN | HRMT1L6 | Heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 6 | Histone-arginine N-methyltransferase PRMT6 | PRMT6 | Protein arginine methyltransferase 6 (PRMT6)
Type:
Protein
Mol. Mass.:
41928.48
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
375
Sequence:
MSQPKKRKLESGGGGEGGEGTEEEDGAEREAALERPRRTKRERDQLYYECYSDVSVHEEMIADRVRTDAYRLGILRNWAALRGKTVLDVGAGTGILSIFCAQAGARRVYAVEASAIWQQAREVVRFNGLEDRVHVLPGPVETVELPEQVDAIVSEWMGYGLLHESMLSSVLHARTKWLKEGGLLLPASAELFIAPISDQMLEWRLGFWSQVKQHYGVDMSCLEGFATRCLMGHSEIVVQGLSGEDVLARPQRFAQLELSRAGLEQELEAGVGGRFRCSCYGSAPMHGFAIWFQVTFPGGESEKPLVLSTSPFHPATHWKQALLYLNEPVQVEQDTDVSGEITLLPSRDNPRRLRVLLRYKVGDQEEKTKDFAMED
  
Inhibitor
Name:
BDBM50580051
Synonyms:
CHEMBL5070897
Type:
Small organic molecule
Emp. Form.:
C23H21BrN2O2S
Mol. Mass.:
469.394
SMILES:
Cc1ccc2NC(=O)CN([C@H](c3cc(C)cc(C)c3)c2c1)C(=O)c1ccc(Br)s1 |r|
Structure:
Search PDB for entries with ligand similarity: