Reaction Details Report a problem with these data
Target
C-C chemokine receptor type 2
Ligand
BDBM50216426
Substrate
n/a
Meas. Tech.
ChEMBL_456638 (CHEMBL922993)
IC50
>10000±n/a nM
Citation
 Lagu, B; Gerchak, C; Pan, M; Hou, C; Singer, M; Malaviya, R; Matheis, M; Olini, G; Cavender, D; Wachter, M Potent and selective CC-chemokine receptor-2 (CCR2) antagonists as a potential treatment for asthma. Bioorg Med Chem Lett 17:4382-6 (2007) [PubMed]  Article 
Target
Name:
C-C chemokine receptor type 2
Synonyms:
C-C chemokine receptor type 2 (CCR2) | CCR2 | CCR2_HUMAN | CMKBR2 | Chemoattractant Cytokine Receptor 2 (CCR2) | Chemokine Receptor Type 2b (CCR2b) | Monocyte chemotactic protein-1 (MCP-1)
Type:
Enzyme
Mol. Mass.:
41932.32
Organism:
Homo sapiens (Human)
Description:
P41597
Residue:
374
Sequence:
MLSTSRSRFIRNTNESGEEVTTFFDYDYGAPCHKFDVKQIGAQLLPPLYSLVFIFGFVGNMLVVLILINCKKLKCLTDIYLLNLAISDLLFLITLPLWAHSAANEWVFGNAMCKLFTGLYHIGYFGGIFFIILLTIDRYLAIVHAVFALKARTVTFGVVTSVITWLVAVFASVPGIIFTKCQKEDSVYVCGPYFPRGWNNFHTIMRNILGLVLPLLIMVICYSGILKTLLRCRNEKKRHRAVRVIFTIMIVYFLFWTPYNIVILLNTFQEFFGLSNCESTSQLDQATQVTETLGMTHCCINPIIYAFVGEKFRSLFHIALGCRIAPLQKPVCGGPGVRPGKNVKVTTQGLLDGRGKGKSIGRAPEASLQDKEGA
  
Inhibitor
Name:
BDBM50216426
Synonyms:
CHEMBL397646 | N-(4-(2,3-dichlorobenzamido)benzyl)-N,N-dimethyl-tetrahydro-2H-pyran-4-aminium
Type:
Small organic molecule
Emp. Form.:
C21H25Cl2N2O2
Mol. Mass.:
408.341
SMILES:
C[N+](C)(Cc1ccc(NC(=O)c2cccc(Cl)c2Cl)cc1)C1CCOCC1
Structure:
Search PDB for entries with ligand similarity: