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Target
Free fatty acid receptor 1
Ligand
BDBM50267028
Substrate
n/a
Meas. Tech.
ChEBML_1701990
Ki
10.0±n/a nM
Citation
 Jurica, EA; Wu, X; Williams, KN; Hernandez, AS; Nirschl, DS; Rampulla, RA; Mathur, A; Zhou, M; Cao, G; Xie, C; Jacob, B; Cai, H; Wang, T; Murphy, BJ; Liu, H; Xu, C; Kunselman, LK; Hicks, MB; Sun, Q; Schnur, DM; Sitkoff, DF; Dierks, EA; Apedo, A; Moore, DB; Foster, KA; Cvijic, ME; Panemangalore, R; Flynn, NA; Maxwell, BD; Hong, Y; Tian, Y; Wilkes, JJ; Zinker, BA; Whaley, JM; Barrish, JC; Robl, JA; Ewing, WR; Ellsworth, BA Discovery of Pyrrolidine-Containing GPR40 Agonists: Stereochemistry Effects a Change in Binding Mode. J Med Chem 60:1417-1431 (2017) [PubMed]  Article 
Target
Name:
Free fatty acid receptor 1
Synonyms:
FFAR1 | FFAR1_HUMAN | G-protein Coupled Receptor 40 | GPR40
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
31473.32
Organism:
Homo sapiens (Human)
Description:
O14842
Residue:
300
Sequence:
MDLPPQLSFGLYVAAFALGFPLNVLAIRGATAHARLRLTPSLVYALNLGCSDLLLTVSLPLKAVEALASGAWPLPASLCPVFAVAHFFPLYAGGGFLAALSAGRYLGAAFPLGYQAFRRPCYSWGVCAAIWALVLCHLGLVFGLEAPGGWLDHSNTSLGINTPVNGSPVCLEAWDPASAGPARFSLSLLLFFLPLAITAFCYVGCLRALARSGLTHRRKLRAAWVAGGALLTLLLCVGPYNASNVASFLYPNLGGSWRKLGLITGAWSVVLNPLVTGYLGRGPGLKTVCAARTQGGKSQK
  
Inhibitor
Name:
BDBM50267028
Synonyms:
CHEMBL4073525
Type:
Small organic molecule
Emp. Form.:
C27H26F3NO4
Mol. Mass.:
485.4948
SMILES:
Cc1cc(OCc2ccccc2)ccc1Oc1ccc(cc1)N1C[C@H](C[C@H]1CC(O)=O)C(F)(F)F |r|
Structure:
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