Reaction Details Report a problem with these data
Target
Reverse transcriptase/RNaseH
Ligand
BDBM50065796
Substrate
n/a
Meas. Tech.
ChEMBL_306441 (CHEMBL829085)
IC50
2000±n/a nM
Citation
Normand-Bayle, M; Bénard, C; Zouhiri, F; Mouscadet, JF; Leh, H; Thomas, CM; Mbemba, G; Desmaële, D; d'Angelo, J New HIV-1 replication inhibitors of the styryquinoline class bearing aroyl/acyl groups at the C-7 position: synthesis and biological activity. Bioorg Med Chem Lett 15:4019-22 (2005) [PubMed] Article
More Info.:
Target
Name:
Reverse transcriptase/RNaseH
Synonyms:
HIV-1 Reverse Transcriptase RNase H | Human immunodeficiency virus type 1 reverse transcriptase | Reverse transcriptase/RNaseH
Type:
PROTEIN
Mol. Mass.:
65229.15
Organism:
Human immunodeficiency virus 1
Description:
ChEMBL_1473730
Residue:
566
Sequence:
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPVFAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKRKSVTVLDVGDAYFSVPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVIYQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGLTTPDKKHQKEPPFLWMGYELHPDKWTVQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIRVRQLCKLLRGTKALTEVIPLTEEAELELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLRTGKYARMRGAHTNDVKQLTEAVQKITTESIVIWGKTPKFKLPIQKETWETWWTEYWQATWIPEWEFVNTPPLVKLWYQLEKEPIVGAETFYVDGAANRETKLGKAGYVTNRGRQKVVTLTDTTNQKTELQAIYLALQDSGLEVNIVTDSQYALGIIQAQPDQSESELVNQIIEQLIKKEKVYLAWVPAHKGIGGNEQVDKLVSAGIRKVLFLDGID
Inhibitor
Name:
BDBM50065796
Synonyms:
(E)-2-(3,4-dihydroxystyryl)-8-hydroxyquinoline-7-carboxylic acid | 2-(3,4-dihydroxystyryl)-8-hydroxyquinoline-7-carboxylic acid | 2-[(E)-2-(3,4-Dihydroxy-phenyl)-vinyl]-8-hydroxy-quinoline-7-carboxylic acid | 2-[2-((E)-3,4-Dihydroxy-phenyl)-vinyl]-8-hydroxy-quinoline-7-carboxylic acid | 2-[2-(3,4-Dihydroxy-phenyl)-vinyl]-8-hydroxy-quinoline-7-carboxylic acid | CHEMBL39092
Type:
Small organic molecule
Emp. Form.:
C18H13NO5
Mol. Mass.:
323.2995
SMILES:
OC(=O)c1ccc2ccc(\C=C\c3ccc(O)c(O)c3)nc2c1O