Reaction Details Report a problem with these data
Target
D(2) dopamine receptor
Ligand
BDBM50281456
Substrate
n/a
Meas. Tech.
ChEMBL_58316 (CHEMBL672710)
Ki
>10000±n/a nM
Citation
 Schow, SR; Tam, SW Novel sigma receptor ligands 2. Bioorg Med Chem Lett 3:221-224 (1993)    Article 
Target
Name:
D(2) dopamine receptor
Synonyms:
D(2) dopamine receptor | DOPAMINE D2 | DOPAMINE D2 Long | DOPAMINE D2 Short | DRD2 | DRD2_HUMAN | Dopamine D2 receptor | Dopamine D2 receptor (D2) | Dopamine D2 receptor (D2R) | Dopamine D2A | Dopamine2-like | d2
Type:
Cell-surface receptors
Mol. Mass.:
50647.10
Organism:
Homo sapiens (Human)
Description:
P14416
Residue:
443
Sequence:
MDPLNLSWYDDDLERQNWSRPFNGSDGKADRPHYNYYATLLTLLIAVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMISIVWVLSFTISCPLLFGLNNADQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRRRRKRVNTKRSSRAFRAHLRAPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRVEAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSTPDSPAKPEKNGHAKDHPKIAKIFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFLKILHC
  
Inhibitor
Name:
BDBM50281456
Synonyms:
9-Benzyloxy-3-phenyl-1-oxa-spiro[5.5]undec-2-en-4-one | CHEMBL72539
Type:
Small organic molecule
Emp. Form.:
C23H24O3
Mol. Mass.:
348.4349
SMILES:
O=C1CC2(CCC(CC2)OCc2ccccc2)OC=C1c1ccccc1 |c:20,(-6.71,4.39,;-5.63,3.29,;-4.16,3.67,;-3.07,2.57,;-1.9,2.99,;-.18,2.37,;.58,3.71,;-.69,3.29,;-2.32,3.92,;2.05,3.32,;3.14,4.41,;4.63,4.02,;5.7,5.09,;7.17,4.71,;7.59,3.22,;6.5,2.13,;5.01,2.53,;-3.48,1.11,;-4.97,.71,;-6.04,1.81,;-7.53,1.42,;-8.6,2.51,;-10.09,2.13,;-10.48,.64,;-9.4,-.45,;-7.92,-.05,)|
Structure:
Search PDB for entries with ligand similarity: