Reaction Details Report a problem with these data
Target
Free fatty acid receptor 1
Ligand
BDBM50019089
Substrate
n/a
Meas. Tech.
ChEMBL_1361426 (CHEMBL3294050)
EC50
130±n/a nM
Citation
 Takano, R; Yoshida, M; Inoue, M; Honda, T; Nakashima, R; Matsumoto, K; Yano, T; Ogata, T; Watanabe, N; Toda, N Discovery of 3-aryl-3-ethoxypropanoic acids as orally active GPR40 agonists. Bioorg Med Chem Lett 24:2949-53 (2014) [PubMed]  Article 
Target
Name:
Free fatty acid receptor 1
Synonyms:
FFAR1 | FFAR1_HUMAN | G-protein Coupled Receptor 40 | GPR40
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
31473.32
Organism:
Homo sapiens (Human)
Description:
O14842
Residue:
300
Sequence:
MDLPPQLSFGLYVAAFALGFPLNVLAIRGATAHARLRLTPSLVYALNLGCSDLLLTVSLPLKAVEALASGAWPLPASLCPVFAVAHFFPLYAGGGFLAALSAGRYLGAAFPLGYQAFRRPCYSWGVCAAIWALVLCHLGLVFGLEAPGGWLDHSNTSLGINTPVNGSPVCLEAWDPASAGPARFSLSLLLFFLPLAITAFCYVGCLRALARSGLTHRRKLRAAWVAGGALLTLLLCVGPYNASNVASFLYPNLGGSWRKLGLITGAWSVVLNPLVTGYLGRGPGLKTVCAARTQGGKSQK
  
Inhibitor
Name:
BDBM50019089
Synonyms:
CHEMBL3288350
Type:
Small organic molecule
Emp. Form.:
C22H22N2O3
Mol. Mass.:
362.4217
SMILES:
Cc1cccc(C)c1-c1cccc(COc2ncc(CCC(O)=O)cn2)c1
Structure:
Search PDB for entries with ligand similarity: