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Target
Serine/threonine-protein kinase Nek7
Ligand
BDBM522959
Substrate
n/a
Meas. Tech.
Enzymatic Assay
IC50
400±n/a nM
Citation
 Bearss, DJ; Kauwe, III, JS; Mollard, AH Inhibitors of NEK7 kinase US Patent  US11161852 Publication Date 11/2/2021 
Target
Name:
Serine/threonine-protein kinase Nek7
Synonyms:
NEK kinase | NEK7 | NEK7_HUMAN
Type:
PROTEIN
Mol. Mass.:
34559.15
Organism:
Homo sapiens (Human)
Description:
ChEMBL_586832
Residue:
302
Sequence:
MDEQSQGMQGPPVPQFQPQKALRPDMGYNTLANFRIEKKIGRGQFSEVYRAACLLDGVPVALKKVQIFDLMDAKARADCIKEIDLLKQLNHPNVIKYYASFIEDNELNIVLELADAGDLSRMIKHFKKQKRLIPERTVWKYFVQLCSALEHMHSRRVMHRDIKPANVFITATGVVKLGDLGLGRFFSSKTTAAHSLVGTPYYMSPERIHENGYNFKSDIWSLGCLLYEMAALQSPFYGDKMNLYSLCKKIEQCDYPPLPSDHYSEELRQLVNMCINPDPEKRPDVTYVYDVAKRMHACTASS
  
Inhibitor
Name:
BDBM522959
Synonyms:
1-(4-(4-amino-7- cyclopropyl-7H- pyrrolo[2,3- d]pyrimidin-5-yl)-2- fluorophenyl)-3-(5- cyclopropylisoxazol-3- yl)urea | US11161852, Compound 6 | US11713321, Example 6
Type:
Small organic molecule
Emp. Form.:
C22H20FN7O2
Mol. Mass.:
433.4383
SMILES:
Nc1ncnc2n(cc(-c3ccc(NC(=O)Nc4cc(on4)C4CC4)c(F)c3)c12)C1CC1
Structure:
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