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Found 635 with Last Name = 'bearss' and Initial = 'dj'
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
University Of Utah

Curated by ChEMBL
LigandPNGBDBM50445346(CHEMBL3104250)
Affinity DataKi:  14nMAssay Description:Non-competitive inhibition of recombinant full-length His6-tagged LSD1 (unknown origin) using dimethylated K4N-terminal H3 peptide as substrate at 1 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
University Of Utah

Curated by ChEMBL
LigandPNGBDBM50445346(CHEMBL3104250)
Affinity DataKi:  32nMAssay Description:Non-competitive inhibition of recombinant full-length His6-tagged LSD1 (unknown origin) using dimethylated K4N-terminal H3 peptide as substrate at 10...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
University Of Utah

Curated by ChEMBL
LigandPNGBDBM50445346(CHEMBL3104250)
Affinity DataKi:  35nMAssay Description:Non-competitive inhibition of recombinant full-length His6-tagged LSD1 (unknown origin) using dimethylated K4N-terminal H3 peptide as substrate at 3 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
University Of Utah

Curated by ChEMBL
LigandPNGBDBM50445346(CHEMBL3104250)
Affinity DataKi:  35nMAssay Description:Non-competitive inhibition of recombinant full-length His6-tagged LSD1 (unknown origin) using dimethylated K4N-terminal H3 peptide as substrate at 30...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
University Of Utah

Curated by ChEMBL
LigandPNGBDBM50445346(CHEMBL3104250)
Affinity DataKi:  55nMAssay Description:Non-competitive inhibition of recombinant full-length His6-tagged LSD1 (unknown origin) using dimethylated K4N-terminal H3 peptide as substrate at 10...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase receptor UFO(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM28031(BMS-777607 | N-{4-[(2-amino-3-chloropyridin-4-yl)o...)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of human recombinant His-tagged AXL kinase using fluorescein-labelled poly-GT as substrate after 60 mins by TR-FRET analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50382425(CHEMBL2022968)
Affinity DataIC50:  3nMAssay Description:Inhibition of Aurora AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
University of Utah Research Foundation

US Patent
LigandPNGBDBM214693(US9296703, 1)
Affinity DataIC50:  4nMT: 2°CAssay Description:The primary assay for compound inhibitory activity was the ADP generation assay described herein. Test compounds were diluted to desired concentratio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase receptor UFO(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM27917(4-cyano-N-[4-(4-methylpiperazin-1-yl)-2-(4-methylp...)
Affinity DataIC50:  6.40nMAssay Description:Inhibition of human recombinant His-tagged AXL kinase using fluorescein-labelled poly-GT as substrate after 60 mins by TR-FRET analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-phosphoinositide-dependent protein kinase 1(Homo sapiens (Human))
Brigham Young University

Curated by ChEMBL
LigandPNGBDBM17004(BX-517 | Indolinone based inhibitor, 4i | [(3Z)-2-...)
Affinity DataIC50:  9nMAssay Description:Inhibition of PDK1 (unknown origin) after 1 hr in presence of Ser/Thr-07 by fluorometric assayMore data for this Ligand-Target Pair
TargetAurora kinase B(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50382425(CHEMBL2022968)
Affinity DataIC50:  12nMAssay Description:Inhibition of Aurora BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
University Of Utah

Curated by ChEMBL
LigandPNGBDBM151608(US8987335, 9 | US9555024, 9)
Affinity DataIC50:  13nMAssay Description:The primary assay for compound inhibitory activity was the LSD1 Inhibitor Screening Assay Kit (Cayman Chemical Company, Ann Arbor, Mich.; Cayman Chem...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
University Of Utah

Curated by ChEMBL
LigandPNGBDBM151611(SP-2509 | US11433053, Example HCI-2509 | US8987335...)
Affinity DataIC50:  13nMAssay Description:The primary assay for compound inhibitory activity was the LSD1 Inhibitor Screening Assay Kit (Cayman Chemical Company, Ann Arbor, Mich.; Cayman Chem...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
University Of Utah

Curated by ChEMBL
LigandPNGBDBM151617(US8987335, 18)
Affinity DataIC50:  13nMAssay Description:The primary assay for compound inhibitory activity was the LSD1 Inhibitor Screening Assay Kit (Cayman Chemical Company, Ann Arbor, Mich.; Cayman Chem...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
University Of Utah

Curated by ChEMBL
LigandPNGBDBM50445346(CHEMBL3104250)
Affinity DataIC50:  13nMAssay Description:Inhibition of LSD1 (unknown origin) using dimethyl K4 peptide as substrate assessed as resorufin level by spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
University Of Utah

Curated by ChEMBL
LigandPNGBDBM151608(US8987335, 9 | US9555024, 9)
Affinity DataIC50:  13nMAssay Description:The primary assay for compound inhibitory activity was the LSD1 Inhibitor Screening Assay Kit (Cayman Chemical Company, Ann Arbor, Mich.; Cayman Chem...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
University Of Utah

Curated by ChEMBL
LigandPNGBDBM151611(SP-2509 | US11433053, Example HCI-2509 | US8987335...)
Affinity DataIC50:  13nMAssay Description:The primary assay for compound inhibitory activity was the LSD1 Inhibitor Screening Assay Kit (Cayman Chemical Company, Ann Arbor, Mich.; Cayman Chem...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
University Of Utah

Curated by ChEMBL
LigandPNGBDBM151617(US8987335, 18)
Affinity DataIC50:  13nMAssay Description:The primary assay for compound inhibitory activity was the LSD1 Inhibitor Screening Assay Kit (Cayman Chemical Company, Ann Arbor, Mich.; Cayman Chem...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase receptor UFO(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50382441(CHEMBL2023349)
Affinity DataIC50:  14nMAssay Description:Inhibition of human recombinant His-tagged AXL kinase using fluorescein-labelled poly-GT as substrate after 60 mins by TR-FRET analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Mer(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM28031(BMS-777607 | N-{4-[(2-amino-3-chloropyridin-4-yl)o...)
Affinity DataIC50:  14nMAssay Description:Inhibition of Mer kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
University Of Utah

Curated by ChEMBL
LigandPNGBDBM50445347(CHEMBL3104252)
Affinity DataIC50:  14nMAssay Description:Inhibition of LSD1 (unknown origin) using dimethyl K4 peptide as substrate assessed as resorufin level by spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase receptor UFO(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50382443(CHEMBL2023351)
Affinity DataIC50:  16nMAssay Description:Inhibition of human recombinant His-tagged AXL kinase using fluorescein-labelled poly-GT as substrate after 60 mins by TR-FRET analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase receptor UFO(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50382414(CHEMBL2022975)
Affinity DataIC50:  19nMAssay Description:Inhibition of human recombinant His-tagged AXL kinase using fluorescein-labelled poly-GT as substrate after 60 mins by TR-FRET analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
University Of Utah

Curated by ChEMBL
LigandPNGBDBM50445348(CHEMBL3104350)
Affinity DataIC50:  19nMAssay Description:Inhibition of LSD1 (unknown origin) using dimethyl K4 peptide as substrate assessed as resorufin level by spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
University Of Utah

Curated by ChEMBL
LigandPNGBDBM50445349(CHEMBL3104261 | US9676701, 63 Enantiomers of 4R...)
Affinity DataIC50:  20nMAssay Description:Inhibition of human recombinant LSD1 using dimethylated H3K4 peptide as substrate after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
University Of Utah

Curated by ChEMBL
LigandPNGBDBM50445366(CHEMBL3104342)
Affinity DataIC50:  25nMAssay Description:Inhibition of human recombinant LSD1 using dimethylated H3K4 peptide as substrate after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase receptor UFO(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50382425(CHEMBL2022968)
Affinity DataIC50:  27nMAssay Description:Inhibition of human recombinant His-tagged AXL kinase using fluorescein-labelled poly-GT as substrate after 60 mins by TR-FRET analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
University Of Utah

Curated by ChEMBL
LigandPNGBDBM151623(US8987335, 24)
Affinity DataIC50:  28nMAssay Description:The primary assay for compound inhibitory activity was the LSD1 Inhibitor Screening Assay Kit (Cayman Chemical Company, Ann Arbor, Mich.; Cayman Chem...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
University Of Utah

Curated by ChEMBL
LigandPNGBDBM151623(US8987335, 24)
Affinity DataIC50:  28nMAssay Description:The primary assay for compound inhibitory activity was the LSD1 Inhibitor Screening Assay Kit (Cayman Chemical Company, Ann Arbor, Mich.; Cayman Chem...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase receptor UFO(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50382442(CHEMBL2023350)
Affinity DataIC50:  30nMAssay Description:Inhibition of human recombinant His-tagged AXL kinase using fluorescein-labelled poly-GT as substrate after 60 mins by TR-FRET analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase receptor UFO(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50382431(CHEMBL2022974)
Affinity DataIC50:  32nMAssay Description:Inhibition of human recombinant His-tagged AXL kinase using fluorescein-labelled poly-GT as substrate after 60 mins by TR-FRET analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
University of Utah Research Foundation

US Patent
LigandPNGBDBM120748(US8703767, 8)
Affinity DataIC50:  33nMT: 2°CAssay Description:The primary assay for compound inhibitory activity was the ADP generation assay described herein. Test compounds were diluted to desired concentratio...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase receptor UFO(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50382433(CHEMBL2022977)
Affinity DataIC50:  37nMAssay Description:Inhibition of human recombinant His-tagged AXL kinase using fluorescein-labelled poly-GT as substrate after 60 mins by TR-FRET analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
University of Utah Research Foundation

US Patent
LigandPNGBDBM120741(US8703767, 1)
Affinity DataIC50:  45nMT: 2°CAssay Description:Activity of compounds was routinely confirmed using a secondary assay as described herein. The secondary assay was a time resolved-FRET kinase assay....More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
University of Utah Research Foundation

US Patent
LigandPNGBDBM120748(US8703767, 8)
Affinity DataIC50:  47nMT: 2°CAssay Description:Activity of compounds was routinely confirmed using a secondary assay as described herein. The secondary assay was a time resolved-FRET kinase assay....More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
University Of Utah

Curated by ChEMBL
LigandPNGBDBM151624(US8987335, 25)
Affinity DataIC50:  49nMAssay Description:The primary assay for compound inhibitory activity was the LSD1 Inhibitor Screening Assay Kit (Cayman Chemical Company, Ann Arbor, Mich.; Cayman Chem...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
University Of Utah

Curated by ChEMBL
LigandPNGBDBM151624(US8987335, 25)
Affinity DataIC50:  49nMAssay Description:The primary assay for compound inhibitory activity was the LSD1 Inhibitor Screening Assay Kit (Cayman Chemical Company, Ann Arbor, Mich.; Cayman Chem...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLeucine-rich repeat serine/threonine-protein kinase 2 [970-2527](Homo sapiens (Human))
Halia Therapeutics

US Patent
LigandPNGBDBM593123(N-((1R,4R)-4-((5-chloro-2-((3- morpholinophenyl)am...)
Affinity DataIC50: <50nMAssay Description:LRRKtide substrate (peptide sequence RLGRDKYKTLRQIRQ, derived from human ezrin [amino acids 561-573], moesin [amino acids 539-553] and radixin [amino...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLeucine-rich repeat serine/threonine-protein kinase 2 [970-2527](Homo sapiens (Human))
Halia Therapeutics

US Patent
LigandPNGBDBM593124(N-((1S,3R)-3-(((5-chloro-2-((4- morpholinophenyl)a...)
Affinity DataIC50: <50nMAssay Description:LRRKtide substrate (peptide sequence RLGRDKYKTLRQIRQ, derived from human ezrin [amino acids 561-573], moesin [amino acids 539-553] and radixin [amino...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLeucine-rich repeat serine/threonine-protein kinase 2 [970-2527](Homo sapiens (Human))
Halia Therapeutics

US Patent
LigandPNGBDBM593125(4-(((1R,4R)-4-((2,2- difluoroethyl)amino)cyclohexy...)
Affinity DataIC50: <50nMAssay Description:LRRKtide substrate (peptide sequence RLGRDKYKTLRQIRQ, derived from human ezrin [amino acids 561-573], moesin [amino acids 539-553] and radixin [amino...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLeucine-rich repeat serine/threonine-protein kinase 2 [970-2527](Homo sapiens (Human))
Halia Therapeutics

US Patent
LigandPNGBDBM593001(4-(((1S,4S)-4- aminocyclohexyl)methoxy)-N-(4- morp...)
Affinity DataIC50: <50nMAssay Description:LRRKtide substrate (peptide sequence RLGRDKYKTLRQIRQ, derived from human ezrin [amino acids 561-573], moesin [amino acids 539-553] and radixin [amino...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLeucine-rich repeat serine/threonine-protein kinase 2 [970-2527](Homo sapiens (Human))
Halia Therapeutics

US Patent
LigandPNGBDBM593003(4-(((1R,4R)-4- aminocyclohexyl)methoxy)-N-(4- morp...)
Affinity DataIC50: <50nMAssay Description:LRRKtide substrate (peptide sequence RLGRDKYKTLRQIRQ, derived from human ezrin [amino acids 561-573], moesin [amino acids 539-553] and radixin [amino...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLeucine-rich repeat serine/threonine-protein kinase 2 [970-2527](Homo sapiens (Human))
Halia Therapeutics

US Patent
LigandPNGBDBM593024(4-(((1R,4R)-4- aminocyclohexyl)methoxy)-N-(3- morp...)
Affinity DataIC50: <50nMAssay Description:LRRKtide substrate (peptide sequence RLGRDKYKTLRQIRQ, derived from human ezrin [amino acids 561-573], moesin [amino acids 539-553] and radixin [amino...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLeucine-rich repeat serine/threonine-protein kinase 2 [970-2527](Homo sapiens (Human))
Halia Therapeutics

US Patent
LigandPNGBDBM593026(4-(((1R,4R)-4- aminocyclohexyl)methoxy)-5- methoxy...)
Affinity DataIC50: <50nMAssay Description:LRRKtide substrate (peptide sequence RLGRDKYKTLRQIRQ, derived from human ezrin [amino acids 561-573], moesin [amino acids 539-553] and radixin [amino...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLeucine-rich repeat serine/threonine-protein kinase 2 [970-2527](Homo sapiens (Human))
Halia Therapeutics

US Patent
LigandPNGBDBM593027(4-(((1R,4R)-4- aminocyclohexyl)methoxy)-5- chloro-...)
Affinity DataIC50: <50nMAssay Description:LRRKtide substrate (peptide sequence RLGRDKYKTLRQIRQ, derived from human ezrin [amino acids 561-573], moesin [amino acids 539-553] and radixin [amino...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLeucine-rich repeat serine/threonine-protein kinase 2 [970-2527](Homo sapiens (Human))
Halia Therapeutics

US Patent
LigandPNGBDBM593028(4-(((1R,4R)-4- aminocyclohexyl)methoxy)-5- fluoro-...)
Affinity DataIC50: <50nMAssay Description:LRRKtide substrate (peptide sequence RLGRDKYKTLRQIRQ, derived from human ezrin [amino acids 561-573], moesin [amino acids 539-553] and radixin [amino...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLeucine-rich repeat serine/threonine-protein kinase 2 [970-2527](Homo sapiens (Human))
Halia Therapeutics

US Patent
LigandPNGBDBM593030(4-(((1R,4R)-4- (aminomethyl)cyclohexyl)methoxy)- N...)
Affinity DataIC50: <50nMAssay Description:LRRKtide substrate (peptide sequence RLGRDKYKTLRQIRQ, derived from human ezrin [amino acids 561-573], moesin [amino acids 539-553] and radixin [amino...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLeucine-rich repeat serine/threonine-protein kinase 2 [970-2527](Homo sapiens (Human))
Halia Therapeutics

US Patent
LigandPNGBDBM593031(4-(((1R,4R)-4- (aminomethyl)cyclohexyl)methoxy)- 5...)
Affinity DataIC50: <50nMAssay Description:LRRKtide substrate (peptide sequence RLGRDKYKTLRQIRQ, derived from human ezrin [amino acids 561-573], moesin [amino acids 539-553] and radixin [amino...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLeucine-rich repeat serine/threonine-protein kinase 2 [970-2527](Homo sapiens (Human))
Halia Therapeutics

US Patent
LigandPNGBDBM593032(4-(((1R,4R)-4- (aminomethyl)cyclohexyl)methoxy)- 5...)
Affinity DataIC50: <50nMAssay Description:LRRKtide substrate (peptide sequence RLGRDKYKTLRQIRQ, derived from human ezrin [amino acids 561-573], moesin [amino acids 539-553] and radixin [amino...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLeucine-rich repeat serine/threonine-protein kinase 2 [970-2527](Homo sapiens (Human))
Halia Therapeutics

US Patent
LigandPNGBDBM593167(2-(4-((5-chloro-4-((4-((3,3- difluorocyclobutyl)am...)
Affinity DataIC50: <50nMAssay Description:LRRKtide substrate (peptide sequence RLGRDKYKTLRQIRQ, derived from human ezrin [amino acids 561-573], moesin [amino acids 539-553] and radixin [amino...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
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