Reaction Details Report a problem with these data
Target
Glucagon-like peptide 1 receptor
Ligand
BDBM559773
Substrate
n/a
Meas. Tech.
GLP-1R ACTIVATION - cAMP Assay 2
IC50
1.20±n/a nM
Citation
 J., BG; S., CJ; Chienhung, C; J., CJ; Chao-I, H; Kavoos, K; G., TJ; E., WN; Zheng-Yu, Y POLYHETEROCYCLIC GLP-1 R MODULATING COMPOUNDS WIPO 0:0 (2022) [PubMed] 
Target
Name:
Glucagon-like peptide 1 receptor
Synonyms:
GLP-1 receptor | GLP-1-R | GLP-1R | GLP1R | GLP1R_HUMAN | Glucagon-like peptide 1 receptor | Glucagon-like peptide 1 receptor (GLP-1)
Type:
Enzyme
Mol. Mass.:
53035.78
Organism:
Homo sapiens (Human)
Description:
P43220
Residue:
463
Sequence:
MAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPWRDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERWRLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS
  
Inhibitor
Name:
BDBM559773
Synonyms:
Methyl (S)-2-((4-(2-((4-cyano-2-fluorobenzyl)oxy)pyrimidin-4-yl)piperidin-1-yl)methyl)-4-(1-methyl-1H-pyrazol-3-yl)-1-(oxetan-2-ylmethyl)-1H-benzo[d]imidazole-6-carboxylate | WO2022109182, Example 4
Type:
Small organic molecule
Emp. Form.:
C34H33FN8O4
Mol. Mass.:
636.6754
SMILES:
Cn1ccc(n1)-c1cc(cc2n(C[C@@H]3CCO3)c(CN3CCC(CC3)c3ccnc(OCc4ccc(cc4F)C#N)n3)nc12)C(O)=O
Structure:
Search PDB for entries with ligand similarity: