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Target
Serine/threonine-protein kinase Nek7
Ligand
BDBM522989
Substrate
n/a
Meas. Tech.
NEK7 Enzymatic Assay
IC50
225±n/a nM
Citation
 Bearss, DJ; Kauwe, III, JS; Mollard, AH Inhibitors of NEK7 kinase US Patent  US11713321 Publication Date 8/1/2023 
Target
Name:
Serine/threonine-protein kinase Nek7
Synonyms:
NEK kinase | NEK7 | NEK7_HUMAN
Type:
PROTEIN
Mol. Mass.:
34559.15
Organism:
Homo sapiens (Human)
Description:
ChEMBL_586832
Residue:
302
Sequence:
MDEQSQGMQGPPVPQFQPQKALRPDMGYNTLANFRIEKKIGRGQFSEVYRAACLLDGVPVALKKVQIFDLMDAKARADCIKEIDLLKQLNHPNVIKYYASFIEDNELNIVLELADAGDLSRMIKHFKKQKRLIPERTVWKYFVQLCSALEHMHSRRVMHRDIKPANVFITATGVVKLGDLGLGRFFSSKTTAAHSLVGTPYYMSPERIHENGYNFKSDIWSLGCLLYEMAALQSPFYGDKMNLYSLCKKIEQCDYPPLPSDHYSEELRQLVNMCINPDPEKRPDVTYVYDVAKRMHACTASS
  
Inhibitor
Name:
BDBM522989
Synonyms:
1-(4-(4-amino-7- cyclopropyl-7H- pyrrolo[2,3- d]pyrimidin-5-yl)-2- fluorophenyl)-3-(3- (1,1,1-trifluoro-2- methylpropan-2- yl)isoxazol-5-yl)urea | US11161852, Compound 12 | US11713321, Example 12
Type:
Small organic molecule
Emp. Form.:
C23H21F4N7O2
Mol. Mass.:
503.4522
SMILES:
CC(C)(c1cc(NC(=O)Nc2ccc(cc2F)-c2cn(C3CC3)c3ncnc(N)c23)on1)C(F)(F)F
Structure:
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