Reaction Details Report a problem with these data
Target
Protein-S-isoprenylcysteine O-methyltransferase
Ligand
BDBM50502488
Substrate
n/a
Meas. Tech.
ICMT Biochemical Assay
IC50
0.170±n/a nM
Citation
 Ho, SY; Poulsen, A; Tan, SW; Ang, SH; Keller, TH Compounds useful as inhibitors of isoprenylcysteine carboxyl methyltransferase US Patent  US11834430 Publication Date 12/5/2023 
Target
Name:
Protein-S-isoprenylcysteine O-methyltransferase
Synonyms:
ICMT | ICMT_HUMAN | Isoprenylcysteine carboxyl methyltransferase | PCCMT
Type:
PROTEIN
Mol. Mass.:
31943.26
Organism:
Homo sapiens (Human)
Description:
ChEMBL_956034
Residue:
284
Sequence:
MAGCAARAPPGSEARLSLATFLLGASVLALPLLTRAGLQGRTGLALYVAGLNALLLLLYRPPRYQIAIRACFLGFVFGCGTLLSFSQSSWSHFGWYMCSLSLFHYSEYLVTAVNNPKSLSLDSFLLNHSLEYTVAALSSWLEFTLENIFWPELKQITWLSVTGLLMVVFGECLRKAAMFTAGSNFNHVVQNEKSDTHTLVTSGVYAWFRHPSYVGWFYWSIGTQVMLCNPICGVSYALTVWRFFRDRTEEEEISLIHFFGEEYLEYKKRVPTGLPFIKGVKVDL
  
Inhibitor
Name:
BDBM50502488
Synonyms:
CHEMBL4449942 | US11834430, Compound 62
Type:
Small organic molecule
Emp. Form.:
C21H19N3O2
Mol. Mass.:
345.3945
SMILES:
N#Cc1ccc(OCCOc2cccc(c2)-n2ccnc2C2CC2)cc1
Structure:
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