Target
Protein-S-isoprenylcysteine O-methyltransferase
Ligand
BDBM637713
Substrate
n/a
Meas. Tech.
ICMT Biochemical Assay
IC50
1.20±n/a nM
Citation
 Ho, SYPoulsen, ATan, SWAng, SHKeller, TH Compounds useful as inhibitors of isoprenylcysteine carboxyl methyltransferase US Patent  US11834430 Publication Date 12/5/2023 
Target
Name:
Protein-S-isoprenylcysteine O-methyltransferase
Synonyms:
ICMT | ICMT_HUMAN | Isoprenylcysteine carboxyl methyltransferase | PCCMT
Type:
PROTEIN
Mol. Mass.:
31943.26
Organism:
Homo sapiens (Human)
Description:
ChEMBL_956034
Residue:
284
Sequence:
MAGCAARAPPGSEARLSLATFLLGASVLALPLLTRAGLQGRTGLALYVAGLNALLLLLYRPPRYQIAIRACFLGFVFGCGTLLSFSQSSWSHFGWYMCSLSLFHYSEYLVTAVNNPKSLSLDSFLLNHSLEYTVAALSSWLEFTLENIFWPELKQITWLSVTGLLMVVFGECLRKAAMFTAGSNFNHVVQNEKSDTHTLVTSGVYAWFRHPSYVGWFYWSIGTQVMLCNPICGVSYALTVWRFFRDRTEEEEISLIHFFGEEYLEYKKRVPTGLPFIKGVKVDL
  
Inhibitor
Name:
BDBM637713
Synonyms:
3-methoxy-4-((1-(3- (1-methyl-1H- pyrazol-5- yl)phenoxy)propan- 2- yl)oxy)benzonitrile | US11834430, Compound 31
Type:
Small organic molecule
Emp. Form.:
C21H21N3O3
Mol. Mass.:
363.4097
SMILES:
COc1cc(ccc1OC(C)COc1cccc(c1)-c1ccnn1C)C#N
Structure:
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