Reaction Details Report a problem with these data
Target
Protein-S-isoprenylcysteine O-methyltransferase
Ligand
BDBM637728
Substrate
n/a
Meas. Tech.
ICMT Biochemical Assay
IC50
1.000±n/a nM
Citation
 Ho, SY; Poulsen, A; Tan, SW; Ang, SH; Keller, TH Compounds useful as inhibitors of isoprenylcysteine carboxyl methyltransferase US Patent  US11834430 Publication Date 12/5/2023 
Target
Name:
Protein-S-isoprenylcysteine O-methyltransferase
Synonyms:
ICMT | ICMT_HUMAN | Isoprenylcysteine carboxyl methyltransferase | PCCMT
Type:
PROTEIN
Mol. Mass.:
31943.26
Organism:
Homo sapiens (Human)
Description:
ChEMBL_956034
Residue:
284
Sequence:
MAGCAARAPPGSEARLSLATFLLGASVLALPLLTRAGLQGRTGLALYVAGLNALLLLLYRPPRYQIAIRACFLGFVFGCGTLLSFSQSSWSHFGWYMCSLSLFHYSEYLVTAVNNPKSLSLDSFLLNHSLEYTVAALSSWLEFTLENIFWPELKQITWLSVTGLLMVVFGECLRKAAMFTAGSNFNHVVQNEKSDTHTLVTSGVYAWFRHPSYVGWFYWSIGTQVMLCNPICGVSYALTVWRFFRDRTEEEEISLIHFFGEEYLEYKKRVPTGLPFIKGVKVDL
  
Inhibitor
Name:
BDBM637728
Synonyms:
(R)-3-fluoro-4-((1- (3-(1-methyl-1H- pyrazol-5- yl)phenoxy)propan- 2- yl)oxy)benzonitrile | US11834430, Compound 46
Type:
Small organic molecule
Emp. Form.:
C20H18FN3O2
Mol. Mass.:
351.3742
SMILES:
C[C@H](COc1cccc(c1)-c1ccnn1C)Oc1ccc(cc1F)C#N |r|
Structure:
Search PDB for entries with ligand similarity: