Reaction Details Report a problem with these data
Target
Protein-S-isoprenylcysteine O-methyltransferase
Ligand
BDBM637800
Substrate
n/a
Meas. Tech.
ICMT Biochemical Assay
IC50
2.20±n/a nM
Citation
 Ho, SY; Poulsen, A; Tan, SW; Ang, SH; Keller, TH Compounds useful as inhibitors of isoprenylcysteine carboxyl methyltransferase US Patent  US11834430 Publication Date 12/5/2023 
Target
Name:
Protein-S-isoprenylcysteine O-methyltransferase
Synonyms:
ICMT | ICMT_HUMAN | Isoprenylcysteine carboxyl methyltransferase | PCCMT
Type:
PROTEIN
Mol. Mass.:
31943.26
Organism:
Homo sapiens (Human)
Description:
ChEMBL_956034
Residue:
284
Sequence:
MAGCAARAPPGSEARLSLATFLLGASVLALPLLTRAGLQGRTGLALYVAGLNALLLLLYRPPRYQIAIRACFLGFVFGCGTLLSFSQSSWSHFGWYMCSLSLFHYSEYLVTAVNNPKSLSLDSFLLNHSLEYTVAALSSWLEFTLENIFWPELKQITWLSVTGLLMVVFGECLRKAAMFTAGSNFNHVVQNEKSDTHTLVTSGVYAWFRHPSYVGWFYWSIGTQVMLCNPICGVSYALTVWRFFRDRTEEEEISLIHFFGEEYLEYKKRVPTGLPFIKGVKVDL
  
Inhibitor
Name:
BDBM637800
Synonyms:
3-chloro-4-(2-(3-(1- cyclopropyl-1H- pyrazol-5- yl)phenoxy)ethoxy) benzonitrile | US11834430, Compound 118
Type:
Small organic molecule
Emp. Form.:
C21H18ClN3O2
Mol. Mass.:
379.84
SMILES:
Clc1cc(ccc1OCCOc1cccc(c1)-c1ccnn1C1CC1)C#N
Structure:
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