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Target
Coagulation factor VII
Ligand
BDBM14517
Substrate
BDBM14496
Meas. Tech.
TF-VIIa Assay
IC50
6000±n/a nM
Citation
 Parlow, JJ; Case, BL; Dice, TA; Fenton, RL; Hayes, MJ; Jones, DE; Neumann, WL; Wood, RS; Lachance, RM; Girard, TJ; Nicholson, NS; Clare, M; Stegeman, RA; Stevens, AM; Stallings, WC; Kurumbail, RG; South, MS Design, parallel synthesis, and crystal structures of pyrazinone antithrombotics as selective inhibitors of the tissue factor VIIa complex. J Med Chem 46:4050-62 (2003) [PubMed]  Article 
Target
Name:
Coagulation factor VII
Synonyms:
Eptacog alfa | F7 | FA7_HUMAN | Factor VIIa | Factor VIIa (fVIIa) | Proconvertin | SPCA | Thrombin and coagulation factor VII | serum prothrombin conversion accelerator
Type:
Enzyme
Mol. Mass.:
51599.89
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
466
Sequence:
MVSQALRLLCLLLGLQGCLAAGGVAKASGGETRDMPWKPGPHRVFVTQEEAHGVLHRRRRANAFLEELRPGSLERECKEEQCSFEEAREIFKDAERTKLFWISYSDGDQCASSPCQNGGSCKDQLQSYICFCLPAFEGRNCETHKDDQLICVNENGGCEQYCSDHTGTKRSCRCHEGYSLLADGVSCTPTVEYPCGKIPILEKRNASKPQGRIVGGKVCPKGECPWQVLLLVNGAQLCGGTLINTIWVVSAAHCFDKIKNWRNLIAVLGEHDLSEHDGDEQSRRVAQVIIPSTYVPGTTNHDIALLRLHQPVVLTDHVVPLCLPERTFSERTLAFVRFSLVSGWGQLLDRGATALELMVLNVPRLMTQDCLQQSRKVGDSPNITEYMFCAGYSDGSKDSCKGDSGGPHATHYRGTWYLTGIVSWGQGCATVGHFGVYTRVSQYIEWLQKLMRSEPRPGVLLRAPFP
  
Inhibitor
Name:
BDBM14517
Synonyms:
N-[(4-carbamimidoylphenyl)methyl]-2-(5-chloro-3-{[(3,5-difluorophenyl)methyl]amino}-2-oxo-6-phenyl-1,2-dihydropyrazin-1-yl)acetamide | Pyrazinone Analog 26d
Type:
Small organic molecule
Emp. Form.:
C27H23ClF2N6O2
Mol. Mass.:
536.96
SMILES:
NC(=N)c1ccc(CNC(=O)Cn2c(c(Cl)nc(NCc3cc(F)cc(F)c3)c2=O)-c2ccccc2)cc1
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
BDBM14496
Synonyms:
Factor VII Chromogenic Substrate | N-Methylsulfonyl-D-Phe-Gly-Arg-4-nitranilide acetate
Type:
Small organic molecule
Emp. Form.:
C24H32N8O7S
Mol. Mass.:
576.625
SMILES:
[#6]S(=O)(=O)[#7]-[#6@H](-[#6]-c1ccccc1)-[#6](=O)-[#7]-[#6]-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#6](=O)-[#7]-c1ccc(cc1)-[#7+](-[#8-])=O
Structure:
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