Reaction Details Report a problem with these data
Target
Coagulation factor VII
Ligand
BDBM14575
Substrate
BDBM14496
Meas. Tech.
TF-VIIa Assay
IC50
430±n/a nM
Citation
Parlow, JJ; Case, BL; Dice, TA; Fenton, RL; Hayes, MJ; Jones, DE; Neumann, WL; Wood, RS; Lachance, RM; Girard, TJ; Nicholson, NS; Clare, M; Stegeman, RA; Stevens, AM; Stallings, WC; Kurumbail, RG; South, MS Design, parallel synthesis, and crystal structures of pyrazinone antithrombotics as selective inhibitors of the tissue factor VIIa complex. J Med Chem 46:4050-62 (2003) [PubMed] Article
More Info.:
Target
Name:
Coagulation factor VII
Synonyms:
Eptacog alfa | F7 | FA7_HUMAN | Factor VIIa | Factor VIIa (fVIIa) | Proconvertin | SPCA | Thrombin and coagulation factor VII | serum prothrombin conversion accelerator
Type:
Enzyme
Mol. Mass.:
51599.89
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
466
Sequence:
MVSQALRLLCLLLGLQGCLAAGGVAKASGGETRDMPWKPGPHRVFVTQEEAHGVLHRRRRANAFLEELRPGSLERECKEEQCSFEEAREIFKDAERTKLFWISYSDGDQCASSPCQNGGSCKDQLQSYICFCLPAFEGRNCETHKDDQLICVNENGGCEQYCSDHTGTKRSCRCHEGYSLLADGVSCTPTVEYPCGKIPILEKRNASKPQGRIVGGKVCPKGECPWQVLLLVNGAQLCGGTLINTIWVVSAAHCFDKIKNWRNLIAVLGEHDLSEHDGDEQSRRVAQVIIPSTYVPGTTNHDIALLRLHQPVVLTDHVVPLCLPERTFSERTLAFVRFSLVSGWGQLLDRGATALELMVLNVPRLMTQDCLQQSRKVGDSPNITEYMFCAGYSDGSKDSCKGDSGGPHATHYRGTWYLTGIVSWGQGCATVGHFGVYTRVSQYIEWLQKLMRSEPRPGVLLRAPFP
Inhibitor
Name:
BDBM14575
Synonyms:
N-[(4-carbamimidoylphenyl)methyl]-2-[5-chloro-6-(2-methylphenyl)-2-oxo-3-[(2-phenylethyl)amino]-1,2-dihydropyrazin-1-yl]acetamide | Pyrazinone Analog 31j
Type:
Small organic molecule
Emp. Form.:
C29H29ClN6O2
Mol. Mass.:
529.033
SMILES:
Cc1ccccc1-c1c(Cl)nc(NCCc2ccccc2)c(=O)n1CC(=O)NCc1ccc(cc1)C(N)=N |(5,2.09,;5,3.63,;6.34,4.4,;6.34,5.94,;5,6.71,;3.67,5.94,;3.67,4.4,;2.34,3.63,;1,4.4,;1,5.94,;-.33,3.63,;-.33,2.09,;-1.67,1.32,;-3,2.09,;-4.33,1.32,;-5.67,2.09,;-5.67,3.63,;-7,4.4,;-8.33,3.63,;-8.33,2.09,;-7,1.32,;1,1.32,;1,-.22,;2.34,2.09,;3.67,1.32,;3.67,-.22,;2.34,-.99,;5,-.99,;6.34,-.22,;7.67,-.99,;9,-.22,;10.34,-.99,;10.34,-2.53,;9,-3.3,;7.67,-2.53,;11.67,-3.3,;13.01,-2.53,;11.67,-4.84,)|
Substrate
Name:
BDBM14496
Synonyms:
Factor VII Chromogenic Substrate | N-Methylsulfonyl-D-Phe-Gly-Arg-4-nitranilide acetate
Type:
Small organic molecule
Emp. Form.:
C24H32N8O7S
Mol. Mass.:
576.625
SMILES:
[#6]S(=O)(=O)[#7]-[#6@H](-[#6]-c1ccccc1)-[#6](=O)-[#7]-[#6]-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#6](=O)-[#7]-c1ccc(cc1)-[#7+](-[#8-])=O