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Target
Phosphatidylinositol 3-kinase regulatory subunit beta
Ligand
BDBM357487
Substrate
n/a
Meas. Tech.
TR-FRET PI3K Beta Assay
IC50
16.0±n/a nM
Citation
 Chandrasekhar, J; Codelli, JA; Naduthambi, D; Patel, L; Perreault, S; Phillips, G; Sedillo, KF; Treiberg, JA; Van Veldhuizen, J; Watkins, WJ Phosphatidylinositol 3-kinase inhibitors US Patent  US10214519 Publication Date 2/26/2019 
Target
Name:
Phosphatidylinositol 3-kinase regulatory subunit beta
Synonyms:
P85B_HUMAN | PI3-kinase regulatory subunit beta | PI3-kinase subunit p85-beta | PI3K regulatory subunit beta | PIK3R2 | Phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta | PtdIns-3-kinase regulatory subunit beta | PtdIns-3-kinase regulatory subunit p85-beta
Type:
Enzyme Subunit
Mol. Mass.:
81542.75
Organism:
Homo sapiens (Human)
Description:
O00459
Residue:
728
Sequence:
MAGPEGFQYRALYPFRRERPEDLELLPGDVLVVSRAALQALGVAEGGERCPQSVGWMPGLNERTRQRGDFPGTYVEFLGPVALARPGPRPRGPRPLPARPRDGAPEPGLTLPDLPEQFSPPDVAPPLLVKLVEAIERTGLDSESHYRPELPAPRTDWSLSDVDQWDTAALADGIKSFLLALPAPLVTPEASAEARRALREAAGPVGPALEPPTLPLHRALTLRFLLQHLGRVASRAPALGPAVRALGATFGPLLLRAPPPPSSPPPGGAPDGSEPSPDFPALLVEKLLQEHLEEQEVAPPALPPKPPKAKPASTVLANGGSPPSLQDAEWYWGDISREEVNEKLRDTPDGTFLVRDASSKIQGEYTLTLRKGGNNKLIKVFHRDGHYGFSEPLTFCSVVDLINHYRHESLAQYNAKLDTRLLYPVSKYQQDQIVKEDSVEAVGAQLKVYHQQYQDKSREYDQLYEEYTRTSQELQMKRTAIEAFNETIKIFEEQGQTQEKCSKEYLERFRREGNEKEMQRILLNSERLKSRIAEIHESRTKLEQQLRAQASDNREIDKRMNSLKPDLMQLRKIRDQYLVWLTQKGARQKKINEWLGIKNETEDQYALMEDEDDLPHHEERTWYVGKINRTQAEEMLSGKRDGTFLIRESSQRGCYACSVVVDGDTKHCVIYRTATGFGFAEPYNLYGSLKELVLHYQHASLVQHNDALTVTLAHPVRAPGPGPPPAAR
  
Inhibitor
Name:
BDBM357487
Synonyms:
US10214519, Example 231
Type:
Small organic molecule
Emp. Form.:
C26H21F2N5O2
Mol. Mass.:
473.474
SMILES:
Fc1ccc(F)c2c(ccnc12)-n1c(nc2c(cc(cc12)N1CCOCC1)-c1ncco1)C1CC1 |(-4.75,6.78,;-4.75,5.24,;-6.08,4.47,;-6.08,2.93,;-4.75,2.16,;-4.75,.62,;-3.41,2.93,;-2.08,2.16,;-.75,2.93,;-.75,4.47,;-2.08,5.24,;-3.41,4.47,;-2.08,.62,;-3.28,-.35,;-2.72,-1.79,;-1.19,-1.71,;-.1,-2.8,;1.39,-2.4,;1.79,-.91,;.7,.18,;-.79,-.22,;3.28,-.52,;4.37,-1.6,;5.85,-1.21,;6.25,.28,;5.16,1.37,;3.67,.97,;-.5,-4.29,;.47,-5.48,;-.37,-6.78,;-1.85,-6.38,;-1.93,-4.84,;-4.76,-.75,;-6.25,-.35,;-5.85,-1.84,)|
Structure:
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