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Found 2029 with Last Name = 'chandrasekhar' and Initial = 'j'
TargetCorticotropin-releasing factor receptor 1(Homo sapiens (Human))
Neurogen

Curated by ChEMBL
LigandPNGBDBM50272695(3-(4-chloro-2-morpholinothiazol-5-yl)-2,6-dimethyl...)
Affinity DataKi:  0.200nMAssay Description:Displacement of [125I]sauvagine from human CRF1 receptor expressed in IMR32 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetB1 bradykinin receptor(Homo sapiens (Human))
Neurogen

Curated by ChEMBL
LigandPNGBDBM50202412(3-Chloro-3'-fluoro-4'-((R)-1-{[1-(2,2,2-trifluoro-...)
Affinity DataKi:  0.440nMAssay Description:Inhibition of human bradykinin B1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetB1 bradykinin receptor(Homo sapiens (Human))
Neurogen

Curated by ChEMBL
LigandPNGBDBM50127438(1-(2-Oxo-5-phenethyl-1-propyl-2,3-dihydro-1H-benzo...)
Affinity DataKi:  0.590nMAssay Description:Inhibition of human bradykinin B1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCorticotropin-releasing factor receptor 1(Homo sapiens (Human))
Neurogen

Curated by ChEMBL
LigandPNGBDBM50132951(8-(2,4-dichlorophenyl)-2-methyl-N,N-dipropylquinol...)
Affinity DataKi:  0.900nMAssay Description:Displacement of [125I]sauvagine from CRF1 receptor expressed in human IMR32 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetB1 bradykinin receptor(RAT)
Neurogen

Curated by ChEMBL
LigandPNGBDBM50127438(1-(2-Oxo-5-phenethyl-1-propyl-2,3-dihydro-1H-benzo...)
Affinity DataKi:  0.920nMAssay Description:Antagonist activity at rat bradykinin B1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(4) dopamine receptor(Homo sapiens (Human))
Neurogen

Curated by ChEMBL
LigandPNGBDBM50092053(2-[4-(4-Chloro-benzyl)-piperazin-1-yl]-1-(2,3-dihy...)
Affinity DataKi:  1.60nMAssay Description:Displacement of [3H]-YM 09151 from D4 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCorticotropin-releasing factor receptor 1(Homo sapiens (Human))
Neurogen

Curated by ChEMBL
LigandPNGBDBM29442(CHEMBL524616 | Pyrazolo[1,5-a]-1,3,5-triazine, 12-...)
Affinity DataKi:  2nMAssay Description:Displacement of [125I]sauvagine from human CRF1 receptor expressed in IMR32 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCorticotropin-releasing factor receptor 1(Homo sapiens (Human))
Neurogen

Curated by ChEMBL
LigandPNGBDBM50348828(CHEMBL1628268 | SR-125543A)
Affinity DataKi:  2nMAssay Description:Displacement of [125I]sauvagine from human CRF1 receptor expressed in IMR32 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCorticotropin-releasing factor receptor 1(Homo sapiens (Human))
Neurogen

Curated by ChEMBL
LigandPNGBDBM50272638(2-(4-chloro-2,6-dimethoxyphenyl)-4-methoxy-6-methy...)
Affinity DataKi:  2nMAssay Description:Displacement of [125I]sauvagine from human CRF1 receptor expressed in IMR32 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCorticotropin-releasing factor receptor 1(Homo sapiens (Human))
Neurogen

Curated by ChEMBL
LigandPNGBDBM50058163(Butyl-[2,5-dimethyl-7-(2,4,6-trimethyl-phenyl)-7H-...)
Affinity DataKi:  2.70nMAssay Description:Displacement of [125I]sauvagine from CRF1 receptor expressed in human IMR32 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(4) dopamine receptor(Homo sapiens (Human))
Neurogen

Curated by ChEMBL
LigandPNGBDBM50124931(5-[4-(4-Chloro-benzyl)-piperazin-1-yl]-1,2,6,7-tet...)
Affinity DataKi:  3nMAssay Description:D4 receptor functional activity was measured inhibition of quinpirole stimulated [35S]GTP-gamma-S binding from cell membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCorticotropin-releasing factor receptor 1(Homo sapiens (Human))
Neurogen

Curated by ChEMBL
LigandPNGBDBM50058163(Butyl-[2,5-dimethyl-7-(2,4,6-trimethyl-phenyl)-7H-...)
Affinity DataKi:  3nMAssay Description:Displacement of [125I]sauvagine from human CRF1 receptor expressed in IMR32 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCorticotropin-releasing factor receptor 1(Homo sapiens (Human))
Neurogen

Curated by ChEMBL
LigandPNGBDBM50116105(3-(6-(dimethylamino)-4-methylpyridin-3-yl)-2,5-dim...)
Affinity DataKi:  3nMAssay Description:Displacement of [125I]sauvagine from human CRF1 receptor expressed in IMR32 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rattus norvegicus (rat))
Neurogen

Curated by ChEMBL
LigandPNGBDBM50001884(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
Affinity DataKi:  4nMAssay Description:Displacement of [3H]prazosin from alpha-1 adrenergic receptor of rat brain homogenateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetD(4) dopamine receptor(Homo sapiens (Human))
Neurogen

Curated by ChEMBL
LigandPNGBDBM50092046(3-[4-(4-Chloro-benzyl)-piperazin-1-yl]-1-ethyl-3,4...)
Affinity DataKi:  4nMAssay Description:Displacement of [3H]-YM 09151 from D4 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(4) dopamine receptor(Homo sapiens (Human))
Neurogen

Curated by ChEMBL
LigandPNGBDBM50124932(5-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1,2,6,7-tet...)
Affinity DataKi:  4nMAssay Description:Displacement of [3H]-YM 09151 from D4 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(4) dopamine receptor(Homo sapiens (Human))
Neurogen

Curated by ChEMBL
LigandPNGBDBM50124931(5-[4-(4-Chloro-benzyl)-piperazin-1-yl]-1,2,6,7-tet...)
Affinity DataKi:  5nMAssay Description:Displacement of [3H]-YM 09151 from D4 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCorticotropin-releasing factor receptor 1(Homo sapiens (Human))
Neurogen

Curated by ChEMBL
LigandPNGBDBM50231916(CHEMBL404351 | N-(cyclopropylmethyl)-1-(2-methoxy-...)
Affinity DataKi:  5nMAssay Description:Displacement of [125I]sauvagine from CRF1 receptor expressed in human IMR32 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCorticotropin-releasing factor receptor 1(Homo sapiens (Human))
Neurogen

Curated by ChEMBL
LigandPNGBDBM50231921(1-(2-methoxy-4,6-dimethylphenyl)-3-methyl-N,N-dipr...)
Affinity DataKi:  6nMAssay Description:Displacement of [125I]sauvagine from human CRF1 receptor expressed in IMR32 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCorticotropin-releasing factor receptor 1(Homo sapiens (Human))
Neurogen

Curated by ChEMBL
LigandPNGBDBM50231921(1-(2-methoxy-4,6-dimethylphenyl)-3-methyl-N,N-dipr...)
Affinity DataKi:  6nMAssay Description:Displacement of [125I]sauvagine from CRF1 receptor expressed in human IMR32 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCorticotropin-releasing factor receptor 1(Homo sapiens (Human))
Neurogen

Curated by ChEMBL
LigandPNGBDBM50272702(4-methoxy-2-(2-methoxy-4,6-bis(trifluoromethyl)phe...)
Affinity DataKi:  6nMAssay Description:Displacement of [125I]sauvagine from human CRF1 receptor expressed in IMR32 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCorticotropin-releasing factor receptor 1(Homo sapiens (Human))
Neurogen

Curated by ChEMBL
LigandPNGBDBM50231925(CHEMBL253914 | N,N-bis(cyclopropylmethyl)-1-(2-met...)
Affinity DataKi:  7nMAssay Description:Displacement of [125I]sauvagine from CRF1 receptor expressed in human IMR32 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCorticotropin-releasing factor receptor 1(Homo sapiens (Human))
Neurogen

Curated by ChEMBL
LigandPNGBDBM50231907(1-(2,4-bis(2,2-difluoroethyl)-6-methoxyphenyl)-3-m...)
Affinity DataKi:  8nMAssay Description:Displacement of [125I]sauvagine from CRF1 receptor expressed in human IMR32 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCorticotropin-releasing factor receptor 1(Homo sapiens (Human))
Neurogen

Curated by ChEMBL
LigandPNGBDBM50272703(4-methoxy-2-(2-methoxy-4,6-dimethylphenyl)-6-methy...)
Affinity DataKi:  8nMAssay Description:Displacement of [125I]sauvagine from human CRF1 receptor expressed in IMR32 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCorticotropin-releasing factor receptor 1(Homo sapiens (Human))
Neurogen

Curated by ChEMBL
LigandPNGBDBM50231927(3-ethyl-1-(2-methoxy-4,6-dimethylphenyl)-N,N-dipro...)
Affinity DataKi:  9nMAssay Description:Displacement of [125I]sauvagine from CRF1 receptor expressed in human IMR32 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCorticotropin-releasing factor receptor 1(Homo sapiens (Human))
Neurogen

Curated by ChEMBL
LigandPNGBDBM50272705(2-(4-(difluoromethyl)-2,6-dimethoxyphenyl)-4-metho...)
Affinity DataKi:  9nMAssay Description:Displacement of [125I]sauvagine from human CRF1 receptor expressed in IMR32 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(4) dopamine receptor(Homo sapiens (Human))
Neurogen

Curated by ChEMBL
LigandPNGBDBM50124934(5-[4-(4-Chloro-benzyl)-piperazin-1-yl]-2-methyl-1,...)
Affinity DataKi:  9nMAssay Description:Displacement of [3H]-YM 09151 from D4 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCorticotropin-releasing factor receptor 1(Homo sapiens (Human))
Neurogen

Curated by ChEMBL
LigandPNGBDBM50272704(2-(4-chloro-2,6-dimethoxyphenyl)-4-methoxy-6-methy...)
Affinity DataKi:  9nMAssay Description:Displacement of [125I]sauvagine from human CRF1 receptor expressed in IMR32 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(4) dopamine receptor(Homo sapiens (Human))
Neurogen

Curated by ChEMBL
LigandPNGBDBM50124935(2-Methyl-5-[4-(4-methyl-benzyl)-piperazin-1-yl]-1,...)
Affinity DataKi:  10nMAssay Description:Displacement of [3H]-YM 09151 from D4 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(4) dopamine receptor(Homo sapiens (Human))
Neurogen

Curated by ChEMBL
LigandPNGBDBM50124936(2,2-Dimethyl-5-[4-(4-methyl-benzyl)-piperazin-1-yl...)
Affinity DataKi:  12nMAssay Description:Displacement of [3H]-YM 09151 from D4 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCorticotropin-releasing factor receptor 1(Homo sapiens (Human))
Neurogen

Curated by ChEMBL
LigandPNGBDBM50231921(1-(2-methoxy-4,6-dimethylphenyl)-3-methyl-N,N-dipr...)
Affinity DataKi:  12nMAssay Description:Antagonist activity at CRF1 receptor expressed in mouse AtT20 cells assessed as inhibition of sauvagine-stimulated cAMP accumulationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCorticotropin-releasing factor receptor 1(Homo sapiens (Human))
Neurogen

Curated by ChEMBL
LigandPNGBDBM50272750(4-methoxy-2-(2-methoxy-4,6-dimethylphenyl)-6-methy...)
Affinity DataKi:  15nMAssay Description:Displacement of [125I]sauvagine from human CRF1 receptor expressed in IMR32 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCorticotropin-releasing factor receptor 1(Homo sapiens (Human))
Neurogen

Curated by ChEMBL
LigandPNGBDBM50272753(4-ethoxy-2-(2-methoxy-4,6-dimethylphenyl)-6-methyl...)
Affinity DataKi:  16nMAssay Description:Displacement of [125I]sauvagine from human CRF1 receptor expressed in IMR32 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(4) dopamine receptor(Homo sapiens (Human))
Neurogen

Curated by ChEMBL
LigandPNGBDBM50001884(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
Affinity DataKi:  17nMAssay Description:Displacement of [3H]-YM 09151 from D4 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetCorticotropin-releasing factor receptor 1(Homo sapiens (Human))
Neurogen

Curated by ChEMBL
LigandPNGBDBM50231919(1-(4-(difluoromethoxy)-2-methoxyphenyl)-3-methyl-N...)
Affinity DataKi:  17nMAssay Description:Displacement of [125I]sauvagine from CRF1 receptor expressed in human IMR32 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(4) dopamine receptor(Homo sapiens (Human))
Neurogen

Curated by ChEMBL
LigandPNGBDBM50124937(5-[4-(4-Chloro-benzyl)-piperazin-1-yl]-2,2-dimethy...)
Affinity DataKi:  19nMAssay Description:Displacement of [3H]-YM 09151 from D4 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Neurogen

Curated by ChEMBL
LigandPNGBDBM50092046(3-[4-(4-Chloro-benzyl)-piperazin-1-yl]-1-ethyl-3,4...)
Affinity DataKi:  21nMAssay Description:Displacement of [3H]-YM 09151 from D2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCorticotropin-releasing factor receptor 1(Homo sapiens (Human))
Neurogen

Curated by ChEMBL
LigandPNGBDBM50231930(1-(4-chloro-2-methylphenyl)-3-methyl-N,N-dipropyli...)
Affinity DataKi:  21nMAssay Description:Displacement of [125I]sauvagine from CRF1 receptor expressed in human IMR32 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCorticotropin-releasing factor receptor 1(Homo sapiens (Human))
Neurogen

Curated by ChEMBL
LigandPNGBDBM50231907(1-(2,4-bis(2,2-difluoroethyl)-6-methoxyphenyl)-3-m...)
Affinity DataKi:  22nMAssay Description:Antagonist activity at CRF1 receptor expressed in mouse AtT20 cells assessed as inhibition of sauvagine-stimulated cAMP accumulationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCorticotropin-releasing factor receptor 1(Homo sapiens (Human))
Neurogen

Curated by ChEMBL
LigandPNGBDBM50272636(4-ethyl-6-methoxy-2-(2-methoxy-4,6-dimethylphenyl)...)
Affinity DataKi:  22nMAssay Description:Displacement of [125I]sauvagine from human CRF1 receptor expressed in IMR32 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Neurogen

Curated by ChEMBL
LigandPNGBDBM50124935(2-Methyl-5-[4-(4-methyl-benzyl)-piperazin-1-yl]-1,...)
Affinity DataKi:  26nMAssay Description:Displacement of [3H]-YM 09151 from D2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCorticotropin-releasing factor receptor 1(Homo sapiens (Human))
Neurogen

Curated by ChEMBL
LigandPNGBDBM50231910(1-(4-methoxy-2,6-dimethylphenyl)-3-methyl-N,N-dipr...)
Affinity DataKi:  26nMAssay Description:Displacement of [125I]sauvagine from CRF1 receptor expressed in human IMR32 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCorticotropin-releasing factor receptor 1(Homo sapiens (Human))
Neurogen

Curated by ChEMBL
LigandPNGBDBM50231909(1-(4-methoxy-2-methylphenyl)-3-methyl-N,N-dipropyl...)
Affinity DataKi:  28nMAssay Description:Displacement of [125I]sauvagine from CRF1 receptor expressed in human IMR32 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(4) dopamine receptor(Homo sapiens (Human))
Neurogen

Curated by ChEMBL
LigandPNGBDBM50124938(5-[4-(5-Chloro-2-methoxy-benzyl)-piperazin-1-yl]-2...)
Affinity DataKi:  29nMAssay Description:Displacement of [3H]-YM 09151 from D4 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCorticotropin-releasing factor receptor 1(Homo sapiens (Human))
Neurogen

Curated by ChEMBL
LigandPNGBDBM50231926(1-(2,4-dimethyl-6-(2-morpholinoethoxy)phenyl)-3-me...)
Affinity DataKi:  30nMAssay Description:Displacement of [125I]sauvagine from CRF1 receptor expressed in human IMR32 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCorticotropin-releasing factor receptor 1(Homo sapiens (Human))
Neurogen

Curated by ChEMBL
LigandPNGBDBM50231912(1-(2-(2-(4-(dipropylamino)-3-methylisoquinolin-1-y...)
Affinity DataKi:  32nMAssay Description:Displacement of [125I]sauvagine from CRF1 receptor expressed in human IMR32 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCorticotropin-releasing factor receptor 1(Homo sapiens (Human))
Neurogen

Curated by ChEMBL
LigandPNGBDBM50272751(4-chloro-2-(2-methoxy-4,6-dimethylphenyl)-6-methyl...)
Affinity DataKi:  33nMAssay Description:Displacement of [125I]sauvagine from human CRF1 receptor expressed in IMR32 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(4) dopamine receptor(Homo sapiens (Human))
Neurogen

Curated by ChEMBL
LigandPNGBDBM50124933(5-[4-(2-Methoxy-4-methyl-benzyl)-piperazin-1-yl]-2...)
Affinity DataKi:  34nMAssay Description:Displacement of [3H]-YM 09151 from D4 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCorticotropin-releasing factor receptor 1(Homo sapiens (Human))
Neurogen

Curated by ChEMBL
LigandPNGBDBM50231923(1-(2-ethyl-4-methoxyphenyl)-3-methyl-N,N-dipropyli...)
Affinity DataKi:  36nMAssay Description:Displacement of [125I]sauvagine from CRF1 receptor expressed in human IMR32 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCorticotropin-releasing factor receptor 1(Homo sapiens (Human))
Neurogen

Curated by ChEMBL
LigandPNGBDBM50231924(1-(2-(2-(4-(dipropylamino)-3-methylisoquinolin-1-y...)
Affinity DataKi:  41nMAssay Description:Displacement of [125I]sauvagine from CRF1 receptor expressed in human IMR32 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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