Reaction Details Report a problem with these data
Target
Tyrosine-protein phosphatase non-receptor type 11 [205-593]
Ligand
BDBM24536
Substrate
BDBM13432
Meas. Tech.
Phosphatase Activity Assay
pH
7±n/a
Temperature
295.15±n/a K
IC50
4500±1700 nM
Citation
Lawrence, HR; Pireddu, R; Chen, L; Luo, Y; Sung, SS; Szymanski, AM; Yip, ML; Guida, WC; Sebti, SM; Wu, J; Lawrence, NJ Inhibitors of Src homology-2 domain containing protein tyrosine phosphatase-2 (Shp2) based on oxindole scaffolds. J Med Chem 51:4948-56 (2008) [PubMed] Article
Target
Name:
Tyrosine-protein phosphatase non-receptor type 11 [205-593]
Synonyms:
PTN11_HUMAN | PTP-1D | PTP-2C | PTP2C | PTPN11 | Protein-Tyrosine Phosphatase SHP-2 | SH-PTP3 | SHPTP2 | Shp2
Type:
Protein phosphatase
Mol. Mass.:
44924.47
Organism:
Homo sapiens (Human)
Description:
Human recombinant GST-fusion SHP-2 (205-593).
Residue:
389
Sequence:
TLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQALLQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQ
Inhibitor
Name:
BDBM24536
Synonyms:
3-{2-[(3Z)-2-oxo-5-(propan-2-ylsulfamoyl)-2,3-dihydro-1H-indol-3-ylidene]hydrazin-1-yl}benzoic acid | Oxindole scaffold, 10a
Type:
Small organic molecule
Emp. Form.:
C18H18N4O5S
Mol. Mass.:
402.424
SMILES:
CC(C)NS(=O)(=O)c1ccc2NC(=O)C(=NNc3cccc(c3)C(O)=O)c2c1 |w:15.15|