Reaction Details Report a problem with these data
Target
Kaposi's sarcoma-associated herpesvirus cyclin homolog
Ligand
BDBM36460
Substrate
n/a
Meas. Tech.
KSHV Pr Inhibition Assay
pH
8±0
Temperature
303.15±0 K
IC50
3.1e+3± 2e+2 nM
Citation
 Shahian, T; Lee, GM; Lazic, A; Arnold, LA; Velusamy, P; Roels, CM; Guy, RK; Craik, CS Inhibition of a viral enzyme by a small-molecule dimer disruptor. Nat Chem Biol 5:640-6 (2009) [PubMed]  Article 
Target
Name:
Kaposi's sarcoma-associated herpesvirus cyclin homolog
Synonyms:
Kaposi's sarcoma-associated herpesvirus (KSHV)
Type:
Enzyme
Mol. Mass.:
28080.00
Organism:
Human herpesvirus 8 (HHV-8) (Kaposi's sarcoma-associated herpesvirus)
Description:
Q98147
Residue:
257
Sequence:
MATANNPPSGLLDPTLCEDRIFYNILEIEPRFLTSDSVFGTFQQSLTSHMRKLLGTWMFSVCQEYNLEPNVVALALNLLDRLLLIKQVSKEHFQKTGSACLLVASKLRSLTPISTSSLCYAAADSFSRQELIDQEKELLEKLAWRTEAVLATDVTSFLLLKLVGGSQHLDFWHHEVNTLITKALVDPKTGSLPASIISAAGCALLVPANVIPQDTHSGGVVPQLASILGCDVSVLQAAVEQILTSVSDFDLRILDSY
  
Inhibitor
Name:
BDBM36460
Synonyms:
3-Benzyl-4-(6-(cyclohexylmethyl)picolinamido)benzoic acid, 2 | CID42628632 | DD2
Type:
Small organic moelcule
Emp. Form.:
C27H28N2O3
Mol. Mass.:
428.5228
SMILES:
OC(=O)c1ccc(NC(=O)c2cccc(CC3CCCCC3)n2)c(Cc2ccccc2)c1
Structure:
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