Reaction Details Report a problem with these data
Target
Prokineticin receptor 1
Ligand
BDBM349632
Substrate
n/a
Meas. Tech.
BIOLOGICAL ASSAY
IC50
3100±n/a nM
Citation
 Mitchell, P; Teall, M Sulfonyl piperidine derivatives and their use for treating prokineticin mediated gastrointestinal disorders US Patent  US10335402 Publication Date 7/2/2019 
Target
Name:
Prokineticin receptor 1
Synonyms:
G-protein coupled receptor 73 | G-protein coupled receptor ZAQ | GPR73 | GPR73a | PK-R1 | PKR1 | PKR1_HUMAN | PROKR1
Type:
enzyme
Mol. Mass.:
44779.92
Organism:
Homo sapiens (Human)
Description:
Q8TCW9
Residue:
393
Sequence:
METTMGFMDDNATNTSTSFLSVLNPHGAHATSFPFNFSYSDYDMPLDEDEDVTNSRTFFAAKIVIGMALVGIMLVCGIGNFIFIAALVRYKKLRNLTNLLIANLAISDFLVAIVCCPFEMDYYVVRQLSWEHGHVLCTSVNYLRTVSLYVSTNALLAIAIDRYLAIVHPLRPRMKCQTATGLIALVWTVSILIAIPSAYFTTETVLVIVKSQEKIFCGQIWPVDQQLYYKSYFLFIFGIEFVGPVVTMTLCYARISRELWFKAVPGFQTEQIRKRLRCRRKTVLVLMCILTAYVLCWAPFYGFTIVRDFFPTVFVKEKHYLTAFYIVECIAMSNSMINTLCFVTVKNDTVKYFKKIMLLHWKASYNGGKSSADLDLKTIGMPATEEVDCIRLK
  
Inhibitor
Name:
BDBM349632
Synonyms:
Methyl 2-(4-Chlorophenyl)-2-(1-((3,5-dimethyl-1H-pyrazol-4-yl) sulfonyl)piperidin-4-ylidene)acetate | US10208016, Compound of Example 2 | US10335402, Example 2
Type:
Small organic molecule
Emp. Form.:
C19H22ClN3O4S
Mol. Mass.:
423.914
SMILES:
COC(=O)C(=C1CCN(CC1)S(=O)(=O)c1c(C)n[nH]c1C)c1ccc(Cl)cc1 |(5.7,-1.69,;4.61,-2.78,;3.12,-2.38,;2.04,-3.47,;2.73,-.89,;1.24,-.49,;.84,1,;-.65,1.39,;-1.74,.31,;-1.34,-1.18,;.15,-1.58,;-3.22,.7,;-2.83,2.19,;-3.62,-.78,;-4.71,1.1,;-6.18,.63,;-6.95,-.71,;-7.08,1.87,;-6.18,3.12,;-4.71,2.64,;-3.38,3.41,;3.81,.2,;5.3,-.2,;6.39,.89,;5.99,2.38,;7.08,3.47,;4.51,2.78,;3.42,1.69,)|
Structure:
Search PDB for entries with ligand similarity: