Reaction Details Report a problem with these data
Target
Sigma non-opioid intracellular receptor 1
Ligand
BDBM82351
Substrate
n/a
Meas. Tech.
Sigma 1 Assay
pH
7.4±0
Temperature
310.15±0 K
Ki
14.2±4 nM
Citation
 Yarim, M; Koksal, M; Schepmann, D; Wünsch, B Synthesis and in vitro Evaluation of Novel Indole-Based Sigma Receptors Ligands. Chem Biol Drug Des 78:869-75 (2011) [PubMed]  Article 
Target
Name:
Sigma non-opioid intracellular receptor 1
Synonyms:
OPRS1 | SGMR1_CAVPO | SIGMAR1 | Sigma 1-type opioid receptor | Sigma non-opioid intracellular receptor 1 | Sigma-1 receptor | Sigma1-receptor | Sigma1R | Sterol isomerase-like protein
Type:
Protein
Mol. Mass.:
25307.17
Organism:
Cavia porcellus (Guinea pig)
Description:
Q60492
Residue:
223
Sequence:
MQWAVGRRWLWVALFLAAVAVLTQIVWLWLGTQNFVFQREEIAQLARQYAGLDHELAFSKLIVELRRLHPVHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSPRHSGRYWAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLGFALADTVFSTQDFLTLFYTLRVYARALQLELTTYLFGQDP
  
Inhibitor
Name:
BDBM82351
Synonyms:
1-{[4-(substitutedphenyl/phenylethyl)piperazin1-yl]methyl}-3-methyl-1 H-indole, 3b
Type:
Small organic molecule
Emp. Form.:
C22H27N3
Mol. Mass.:
333.4699
SMILES:
Cc1cn(CN2CCN(CCc3ccccc3)CC2)c2ccccc12
Structure:
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