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Target
Muscarinic acetylcholine receptor M5
Ligand
BDBM50249403
Substrate
n/a
Meas. Tech.
ChEBML_1679927
EC50
>30000±n/a nM
Citation
 Melancon, BJ; Wood, MR; Noetzel, MJ; Nance, KD; Engelberg, EM; Han, C; Lamsal, A; Chang, S; Cho, HP; Byers, FW; Bubser, M; Jones, CK; Niswender, CM; Wood, MW; Engers, DW; Wu, D; Brandon, NJ; Duggan, ME; Conn, PJ; Bridges, TM; Lindsley, CW Optimization of M Bioorg Med Chem Lett 27:2296-2301 (2017) [PubMed]  Article 
Target
Name:
Muscarinic acetylcholine receptor M5
Synonyms:
ACM5_RAT | Cholinergic, muscarinic M5 | Chrm-5 | Chrm5 | Muscarinic acetylcholine receptor | Muscarinic acetylcholine receptor M5
Type:
Enzyme Catalytic Domain
Mol. Mass.:
60161.80
Organism:
RAT
Description:
Cholinergic, muscarinic M5 CHRM5 RAT::P08911
Residue:
531
Sequence:
MEGESYNESTVNGTPVNHQALERHGLWEVITIAVVTAVVSLMTIVGNVLVMISFKVNSQLKTVNNYYLLSLACADLIIGIFSMNLYTTYILMGRWVLGSLACDLWLALDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTPKRAGIMIGLAWLVSFILWAPAILCWQYLVGKRTVPPDECQIQFLSEPTITFGTAIAAFYIPVSVMTILYCRIYRETEKRTKDLADLQGSDSVAEAKKREPAQRTLLRSFFSCPRPSLAQRERNQASWSSSRRSTSTTGKTTQATDLSADWEKAEQVTTCSSYPSSEDEAKPTTDPVFQMVYKSEAKESPGKESNTQETKETVVNTRTENSDYDTPKYFLSPAAAHRLKSQKCVAYKFRLVVKADGTQETNNGCRKVKIMPCSFPVSKDPSTKGPDPNLSHQMTKRKRMVLVKERKAAQTLSAILLAFIITWTPYNIMVLVSTFCDKCVPVTLWHLGYWLCYVNSTINPICYALCNRTFRKTFKLLLLCRWKKKKVEEKLYWQGNSKLP
  
Inhibitor
Name:
BDBM50249403
Synonyms:
CHEMBL4091821
Type:
Small organic molecule
Emp. Form.:
C21H18FN5OS
Mol. Mass.:
407.464
SMILES:
Cc1nnc2sc(C(=O)NCc3ccc(cc3)-c3cccnc3F)c(N)c2c1C
Structure:
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