Affinity DataKi: 3nMAssay Description:Displacement of [3H]AMPA from homomeric recombinant GluA2 receptor (unknown origin)More data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Vanderbilt University Institute of Imaging Science
Curated by ChEMBL
Vanderbilt University Institute of Imaging Science
Curated by ChEMBL
Affinity DataKi: 4.40nMAssay Description:Negative allosteric modulation of rat mGlu5 receptor expressed in HEK293A cells assessed as inhibition of glutamate induced-calcium mobilization prei...More data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Vanderbilt University Medical Center
Curated by ChEMBL
Vanderbilt University Medical Center
Curated by ChEMBL
Affinity DataKi: 6.80nMAssay Description:Displacement of [3H]3-methoxy-5-(pyridin-2-ylethynyl)pyridine from mGlu5 receptor allosteric binding site (unknown origin)More data for this Ligand-Target Pair
TargetGlutamate receptor ionotropic, kainate 1(Homo sapiens (Human))
Centro De Investigaci�N Lilly
Curated by ChEMBL
Centro De Investigaci�N Lilly
Curated by ChEMBL
Affinity DataKi: 20nMAssay Description:Displacement of [3H]ATPA from human Gluk1 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 28nMAssay Description:Inhibition of human dopamine D4 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 36nMAssay Description:Inhibition of human dopamine D4 receptorMore data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Vanderbilt University Institute of Imaging Science
Curated by ChEMBL
Vanderbilt University Institute of Imaging Science
Curated by ChEMBL
Affinity DataKi: 37nMAssay Description:Displacement of [3H]methoxyPEPy from rat mGlu5 expressed in HEK293A cells after 1 hr by scintillation counting methodMore data for this Ligand-Target Pair
Affinity DataKi: 43nMAssay Description:Inhibition of human dopamine D4 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 46nMAssay Description:Inhibition of human dopamine D4 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 65nMAssay Description:Inhibition of human dopamine D4 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 68nMAssay Description:Displacement of [3H]-NMS from rat muscarinic M5 receptor stably expressed in CHO cells membrane by topCount scintillation counting methodMore data for this Ligand-Target Pair
Affinity DataKi: 70nMAssay Description:Inhibition of human dopamine D4 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 81nMAssay Description:Inhibition of human dopamine D4 receptorMore data for this Ligand-Target Pair
TargetGlutamate receptor ionotropic, kainate 1(Homo sapiens (Human))
Centro De Investigaci�N Lilly
Curated by ChEMBL
Centro De Investigaci�N Lilly
Curated by ChEMBL
Affinity DataKi: 90nMAssay Description:Displacement of [3H]ATPA from human Gluk1 receptorMore data for this Ligand-Target Pair
TargetGlutamate receptor ionotropic, kainate 1(Homo sapiens (Human))
Centro De Investigaci�N Lilly
Curated by ChEMBL
Centro De Investigaci�N Lilly
Curated by ChEMBL
Affinity DataKi: 100nMAssay Description:Displacement of [3H]ATPA from human Gluk1 receptorMore data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Vanderbilt University Institute of Imaging Science
Curated by ChEMBL
Vanderbilt University Institute of Imaging Science
Curated by ChEMBL
Affinity DataKi: 100nMAssay Description:Displacement of [3H]methoxy-PEPy from rat mGlu5 receptor expressed in HEK293A cells after 60 mins by scintillation countingMore data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Vanderbilt University Institute of Imaging Science
Curated by ChEMBL
Vanderbilt University Institute of Imaging Science
Curated by ChEMBL
Affinity DataKi: 102nMAssay Description:Displacement of [3H]methoxy-PEPy from rat mGlu5 receptor expressed in HEK293A cells after 60 mins by scintillation countingMore data for this Ligand-Target Pair
Affinity DataKi: 110nMAssay Description:Inhibition of human dopamine D4 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 140nMAssay Description:Inhibition of human dopamine D4 receptorMore data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Vanderbilt University Institute of Imaging Science
Curated by ChEMBL
Vanderbilt University Institute of Imaging Science
Curated by ChEMBL
Affinity DataKi: 153nMAssay Description:Displacement of [3H]methoxyPEPy from rat mGluR5 expressed in human HEK293 cells after 1 hr by scintillation counterMore data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Vanderbilt University Institute of Imaging Science
Curated by ChEMBL
Vanderbilt University Institute of Imaging Science
Curated by ChEMBL
Affinity DataKi: 157nMAssay Description:Displacement of [3H]methoxy-PEPy from rat mGlu5 receptor expressed in HEK293A cells after 60 mins by scintillation countingMore data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M5(Homo sapiens (Human))
Vanderbilt University Medical Center
Curated by ChEMBL
Vanderbilt University Medical Center
Curated by ChEMBL
Affinity DataKi: 159nMAssay Description:Displacement of [3H]NMS from human muscarinic M5 receptor expressed in CHO cells coexpressing Gq protein by scintillation counting in presence of ace...More data for this Ligand-Target Pair
TargetGlutamate receptor ionotropic, kainate 1(Homo sapiens (Human))
Centro De Investigaci�N Lilly
Curated by ChEMBL
Centro De Investigaci�N Lilly
Curated by ChEMBL
Affinity DataKi: 160nMAssay Description:Displacement of [3H]ATPA from human Gluk1 receptorMore data for this Ligand-Target Pair
TargetGlutamate receptor ionotropic, kainate 1(Homo sapiens (Human))
Centro De Investigaci�N Lilly
Curated by ChEMBL
Centro De Investigaci�N Lilly
Curated by ChEMBL
Affinity DataKi: 160nMAssay Description:Displacement of [3H]ATPA from human Gluk1 receptorMore data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Vanderbilt University Institute of Imaging Science
Curated by ChEMBL
Vanderbilt University Institute of Imaging Science
Curated by ChEMBL
Affinity DataKi: 195nMAssay Description:Displacement of [3H]methoxyPEPy from rat mGluR5 expressed in human HEK293 cells after 1 hr by scintillation counterMore data for this Ligand-Target Pair
TargetGlutamate receptor ionotropic, kainate 1(Homo sapiens (Human))
Centro De Investigaci�N Lilly
Curated by ChEMBL
Centro De Investigaci�N Lilly
Curated by ChEMBL
Affinity DataKi: 200nMAssay Description:Displacement of [3H]ATPA from human Gluk1 receptorMore data for this Ligand-Target Pair
TargetGlutamate receptor ionotropic, kainate 1(Homo sapiens (Human))
Centro De Investigaci�N Lilly
Curated by ChEMBL
Centro De Investigaci�N Lilly
Curated by ChEMBL
Affinity DataKi: 200nMAssay Description:Displacement of [3H]ATPA from human Gluk1 receptorMore data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Vanderbilt University Institute of Imaging Science
Curated by ChEMBL
Vanderbilt University Institute of Imaging Science
Curated by ChEMBL
Affinity DataKi: 206nMAssay Description:Displacement of [3H]methoxy-PEPy from rat mGlu5 receptor expressed in HEK293A cells after 60 mins by scintillation countingMore data for this Ligand-Target Pair
Affinity DataKi: 210nMAssay Description:Inhibition of [3H]-AMPA binding to human GluR2 receptors expressed in HEK 293 cellsMore data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Vanderbilt University Institute of Imaging Science
Curated by ChEMBL
Vanderbilt University Institute of Imaging Science
Curated by ChEMBL
Affinity DataKi: 240nMAssay Description:Negative allosteric modulation of rat mGlu5 receptor expressed in HEK293A cells assessed as inhibition of glutamate induced-calcium mobilization prei...More data for this Ligand-Target Pair
Affinity DataKi: 320nMAssay Description:Inhibition of human dopamine D4 receptorMore data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Vanderbilt University Institute of Imaging Science
Curated by ChEMBL
Vanderbilt University Institute of Imaging Science
Curated by ChEMBL
Affinity DataKi: 388nMAssay Description:Displacement of [3H]-3-methoxy-5-(pyridin-2-ylethynyl)pyridine from rat mGlu5 receptor expressed in HEK293A cell membranes after 1 hr by scintillatio...More data for this Ligand-Target Pair
Affinity DataKi: 400nMAssay Description:Displacement of [3H]AMPA from homomeric recombinant GluA2 receptor (unknown origin)More data for this Ligand-Target Pair
TargetGlutamate receptor ionotropic, kainate 1(Homo sapiens (Human))
Centro De Investigaci�N Lilly
Curated by ChEMBL
Centro De Investigaci�N Lilly
Curated by ChEMBL
Affinity DataKi: 400nMAssay Description:Displacement of [3H]ATPA from human Gluk1 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 410nMAssay Description:Inhibition of human dopamine D4 receptorMore data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Vanderbilt University Institute of Imaging Science
Curated by ChEMBL
Vanderbilt University Institute of Imaging Science
Curated by ChEMBL
Affinity DataKi: 440nMAssay Description:Negative allosteric modulation at rat mGluR5 receptorMore data for this Ligand-Target Pair
TargetGlutamate receptor ionotropic, kainate 1(Homo sapiens (Human))
Centro De Investigaci�N Lilly
Curated by ChEMBL
Centro De Investigaci�N Lilly
Curated by ChEMBL
Affinity DataKi: 500nMAssay Description:Binding affinity to GluK1 receptor (unknown origin)More data for this Ligand-Target Pair
TargetGlutamate receptor ionotropic, kainate 1(Homo sapiens (Human))
Centro De Investigaci�N Lilly
Curated by ChEMBL
Centro De Investigaci�N Lilly
Curated by ChEMBL
Affinity DataKi: 600nMAssay Description:Displacement of [3H]ATPA from human Gluk1 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 650nMAssay Description:Displacement of [3H] substance P from recombinant human NK1 receptor expressed in CHO cells after 90 mins by scintillation counting methodMore data for this Ligand-Target Pair
TargetGlutamate receptor ionotropic, kainate 1(Homo sapiens (Human))
Centro De Investigaci�N Lilly
Curated by ChEMBL
Centro De Investigaci�N Lilly
Curated by ChEMBL
Affinity DataKi: 700nMAssay Description:Displacement of [3H]ATPA from human Gluk1 receptorMore data for this Ligand-Target Pair
TargetGlutamate receptor ionotropic, kainate 1(Homo sapiens (Human))
Centro De Investigaci�N Lilly
Curated by ChEMBL
Centro De Investigaci�N Lilly
Curated by ChEMBL
Affinity DataKi: 800nMAssay Description:Displacement of [3H]ATPA from human Gluk1 receptorMore data for this Ligand-Target Pair
TargetGlutamate receptor ionotropic, kainate 1(Homo sapiens (Human))
Centro De Investigaci�N Lilly
Curated by ChEMBL
Centro De Investigaci�N Lilly
Curated by ChEMBL
Affinity DataKi: 800nMAssay Description:Binding affinity to GluK1 receptor (unknown origin)More data for this Ligand-Target Pair
TargetGlutamate receptor ionotropic, kainate 1(Homo sapiens (Human))
Centro De Investigaci�N Lilly
Curated by ChEMBL
Centro De Investigaci�N Lilly
Curated by ChEMBL
Affinity DataKi: 900nMAssay Description:Binding affinity to GluK1 receptor (unknown origin)More data for this Ligand-Target Pair
TargetGlutamate receptor ionotropic, kainate 1(Homo sapiens (Human))
Centro De Investigaci�N Lilly
Curated by ChEMBL
Centro De Investigaci�N Lilly
Curated by ChEMBL
Affinity DataKi: 900nMAssay Description:Displacement of [3H]ATPA from human Gluk1 receptorMore data for this Ligand-Target Pair
TargetGlutamate receptor ionotropic, kainate 1(Homo sapiens (Human))
Centro De Investigaci�N Lilly
Curated by ChEMBL
Centro De Investigaci�N Lilly
Curated by ChEMBL
Affinity DataKi: 900nMAssay Description:Displacement of [3H]ATPA from human Gluk1 receptorMore data for this Ligand-Target Pair
TargetGlutamate receptor ionotropic, kainate 1(Homo sapiens (Human))
Centro De Investigaci�N Lilly
Curated by ChEMBL
Centro De Investigaci�N Lilly
Curated by ChEMBL
Affinity DataKi: 900nMAssay Description:Displacement of [3H]ATPA from human Gluk1 receptorMore data for this Ligand-Target Pair
TargetGlutamate receptor ionotropic, kainate 1(Homo sapiens (Human))
Centro De Investigaci�N Lilly
Curated by ChEMBL
Centro De Investigaci�N Lilly
Curated by ChEMBL
Affinity DataKi: 1.00E+3nMAssay Description:Displacement of [3H]ATPA from human Gluk1 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 1.02E+3nMAssay Description:Inhibition of human dopamine D4 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 1.07E+3nMAssay Description:Inhibition of human dopamine D4 receptorMore data for this Ligand-Target Pair
TargetGlutamate receptor ionotropic, kainate 1(Homo sapiens (Human))
Centro De Investigaci�N Lilly
Curated by ChEMBL
Centro De Investigaci�N Lilly
Curated by ChEMBL
Affinity DataKi: 1.10E+3nMAssay Description:Displacement of [3H]ATPA from human Gluk1 receptorMore data for this Ligand-Target Pair