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Target
Renin
Ligand
BDBM50011346
Substrate
n/a
Meas. Tech.
ChEBML_195778
IC50
1.2±n/a nM
Citation
 Thaisrivongs, S; Pals, DT; DuCharme, DW; Turner, SR; DeGraaf, GL; Lawson, JA; Couch, SJ; Williams, MV Renin inhibitory peptides. Incorporation of polar, hydrophilic end groups into an active renin inhibitory peptide template and their evaluation in a human renin infused rat model and in conscious sodium-depleted monkeys. J Med Chem 34:633-42 (1991) [PubMed]  Article 
Target
Name:
Renin
Synonyms:
Angiotensinogenase | REN | RENI_HUMAN
Type:
Enzyme
Mol. Mass.:
45058.99
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
406
Sequence:
MDGWRRMPRWGLLLLLWGSCTFGLPTDTTTFKRIFLKRMPSIRESLKERGVDMARLGPEWSQPMKRLTLGNTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRLYTACVYHKLFDASDSSSYKHNGTELTLRYSTGTVSGFLSQDIITVGGITVTQMFGEVTEMPALPFMLAEFDGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYNRDSENSQSLGGQIVLGGSDPQHYEGNFHYINLIKTGVWQIQMKGVSVGSSTLLCEDGCLALVDTGASYISGSTSSIEKLMEALGAKKRLFDYVVKCNEGPTLPDISFHLGGKEYTLTSADYVFQESYSSKKLCTLAIHAMDIPPPTGPTWALGATFIRKFYTEFDRRNNRIGFALAR
  
Inhibitor
Name:
BDBM50011346
Synonyms:
CHEMBL3143482 | Sodium; 2-{[7-(1-{[1-(2-hydroxy-1-isobutyl-5-methyl-4-{2-methyl-1-[(1-oxy-pyridin-2-ylmethyl)-carbamoyl]-butylcarbamoyl}-hexylcarbamoyl)-2-(3H-imidazol-4-yl)-ethyl]-methyl-carbamoyl}-2-phenyl-ethylcarbamoyl)-heptanoyl]-methyl-amino}-ethanesulfonate
Type:
Small organic molecule
Emp. Form.:
C51H78N9NaO11S
Mol. Mass.:
1048.273
SMILES:
[Na+].CC[C@H](C)[C@H](NC(=O)[C@@H](C[C@H](O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)N(C)C(=O)[C@H](Cc1ccccc1)NC(=O)CCCCCCC(=O)N(C)CCS([O-])(=O)=O)C(C)C)C(=O)NCc1cccc[n+]1[O-] |r|
Structure:
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