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Target
Potassium-transporting ATPase alpha chain 1
Ligand
BDBM50013236
Substrate
n/a
Meas. Tech.
ChEBML_76081
IC50
530±n/a nM
Citation
 Brown, TH; Ife, RJ; Keeling, DJ; Laing, SM; Leach, CA; Parsons, ME; Price, CA; Reavill, DR; Wiggall, KJ Reversible inhibitors of the gastric (H+/K+)-ATPase. 1. 1-Aryl-4-methylpyrrolo[3,2-c]quinolines as conformationally restrained analogues of 4-(arylamino)quinolines. J Med Chem 33:527-33 (1990) [PubMed]  Article 
Target
Name:
Potassium-transporting ATPase alpha chain 1
Synonyms:
ATP4A | ATP4A_PIG | Gastric H(+)/K(+) ATPase subunit alpha | H+/K+-ATPase | Na/K-ATPase | Potassium-transporting ATPase | Potassium-transporting ATPase alpha chain 1 | Proton pump
Type:
Enzyme
Mol. Mass.:
114279.23
Organism:
Sus scrofa (Pig)
Description:
P19156
Residue:
1034
Sequence:
MGKAENYELYQVELGPGPSGDMAAKMSKKKAGRGGGKRKEKLENMKKEMEINDHQLSVAELEQKYQTSATKGLSASLAAELLLRDGPNALRPPRGTPEYVKFARQLAGGLQCLMWVAAAICLIAFAIQASEGDLTTDDNLYLALALIAVVVVTGCFGYYQEFKSTNIIASFKNLVPQQATVIRDGDKFQINADQLVVGDLVEMKGGDRVPADIRILQAQGRKVDNSSLTGESEPQTRSPECTHESPLETRNIAFFSTMCLEGTAQGLVVNTGDRTIIGRIASLASGVENEKTPIAIEIEHFVDIIAGLAILFGATFFIVAMCIGYTFLRAMVFFMAIVVAYVPEGLLATVTVCLSLTAKRLASKNCVVKNLEAVETLGSTSVICSDKTGTLTQNRMTVSHLWFDNHIHSADTTEDQSGQTFDQSSETWRALCRVLTLCNRAAFKSGQDAVPVPKRIVIGDASETALLKFSELTLGNAMGYRERFPKVCEIPFNSTNKFQLSIHTLEDPRDPRHVLVMKGAPERVLERCSSILIKGQELPLDEQWREAFQTAYLSLGGLGERVLGFCQLYLSEKDYPPGYAFDVEAMNFPTSGLSFAGLVSMIDPPRATVPDAVLKCRTAGIRVIMVTGDHPITAKAIAASVGIISEGSETVEDIAARLRVPVDQVNRKDARACVINGMQLKDMDPSELVEALRTHPEMVFARTSPQQKLVIVESCQRLGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDAAKNAADMILLDDNFASIVTGVEQGRLIFDNLKKSIAYTLTKNIPELTPYLIYITVSVPLPLGCITILFIELCTDIFPSVSLAYEKAESDIMHLRPRNPKRDRLVNEPLAAYSYFQIGAIQSFAGFTDYFTAMAQEGWFPLLCVGLRPQWENHHLQDLQDSYGQEWTFGQRLYQQYTCYTVFFISIEMCQIADVLIRKTRRLSAFQQGFFRNRILVIAIVFQVCIGCFLCYCPGMPNIFNFMPIRFQWWLVPMPFGLLIFVYDEIRKLGVRCCPGSWWDQELYY
  
Inhibitor
Name:
BDBM50013236
Synonyms:
1-(4-Methoxy-2-methyl-phenyl)-4-methyl-2,3-dihydro-1H-pyrrolo[3,2-c]quinoline | CHEMBL440726
Type:
Small organic molecule
Emp. Form.:
C20H20N2O
Mol. Mass.:
304.3856
SMILES:
COc1ccc(N2CCc3c2c2ccccc2nc3C)c(C)c1
Structure:
Search PDB for entries with ligand similarity: