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Target
Renin
Ligand
BDBM50195782
Substrate
n/a
Meas. Tech.
ChEMBL_1712831 (CHEMBL4122880)
IC50
0.790000±n/a nM
Citation
 Tokuhara, H; Imaeda, Y; Fukase, Y; Iwanaga, K; Taya, N; Watanabe, K; Kanagawa, R; Matsuda, K; Kajimoto, Y; Kusumoto, K; Kondo, M; Snell, G; Behnke, CA; Kuroita, T Discovery of benzimidazole derivatives as orally active renin inhibitors: Optimization of 3,5-disubstituted piperidine to improve pharmacokinetic profile. Bioorg Med Chem 26:3261-3286 (2018) [PubMed]  Article 
Target
Name:
Renin
Synonyms:
Angiotensinogenase | REN | RENI_HUMAN
Type:
Enzyme
Mol. Mass.:
45058.99
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
406
Sequence:
MDGWRRMPRWGLLLLLWGSCTFGLPTDTTTFKRIFLKRMPSIRESLKERGVDMARLGPEWSQPMKRLTLGNTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRLYTACVYHKLFDASDSSSYKHNGTELTLRYSTGTVSGFLSQDIITVGGITVTQMFGEVTEMPALPFMLAEFDGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYNRDSENSQSLGGQIVLGGSDPQHYEGNFHYINLIKTGVWQIQMKGVSVGSSTLLCEDGCLALVDTGASYISGSTSSIEKLMEALGAKKRLFDYVVKCNEGPTLPDISFHLGGKEYTLTSADYVFQESYSSKKLCTLAIHAMDIPPPTGPTWALGATFIRKFYTEFDRRNNRIGFALAR
  
Inhibitor
Name:
BDBM50195782
Synonyms:
CHEMBL3958809
Type:
Small organic molecule
Emp. Form.:
C27H46N6O4
Mol. Mass.:
518.6919
SMILES:
COCCCNc1nc(ncc1C(=O)N(CC(C)C)[C@@H]1CNC[C@@H](C1)C(=O)N1CCOCC1)C(C)(C)C |r|
Structure:
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