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Target
Sodium-dependent phosphate transporter 2
Ligand
BDBM50341385
Substrate
n/a
Meas. Tech.
ChEMBL_1734219 (CHEMBL4149755)
IC50
>25000±n/a nM
Citation
 Filipski, KJ; Sammons, MF; Bhattacharya, SK; Panteleev, J; Brown, JA; Loria, PM; Boehm, M; Smith, AC; Shavnya, A; Conn, EL; Song, K; Weng, Y; Facemire, C; Jüppner, H; Clerin, V Discovery of Orally Bioavailable Selective Inhibitors of the Sodium-Phosphate Cotransporter NaPi2a (SLC34A1). ACS Med Chem Lett 9:440-445 (2018) [PubMed]  Article 
Target
Name:
Sodium-dependent phosphate transporter 2
Synonyms:
GLVR-2 | GLVR2 | Gibbon ape leukemia virus receptor 2 | PIT2 | Phosphate transporter 2 | PiT-2 | S20A2_HUMAN | SLC20A2 | Sodium-dependent phosphate transporter 2 | Solute carrier family 20 member 2 | hPit2
Type:
PROTEIN
Mol. Mass.:
70391.57
Organism:
Homo sapiens
Description:
ChEMBL_118051
Residue:
652
Sequence:
MAMDEYLWMVILGFIIAFILAFSVGANDVANSFGTAVGSGVVTLRQACILASIFETTGSVLLGAKVGETIRKGIIDVNLYNETVETLMAGEVSAMVGSAVWQLIASFLRLPISGTHCIVGSTIGFSLVAIGTKGVQWMELVKIVASWFISPLLSGFMSGLLFVLIRIFILKKEDPVPNGLRALPVFYAATIAINVFSIMYTGAPVLGLVLPMWAIALISFGVALLFAFFVWLFVCPWMRRKITGKLQKEGALSRVSDESLSKVQEAESPVFKELPGAKANDDSTIPLTGAAGETLGTSEGTSAGSHPRAAYGRALSMTHGSVKSPISNGTFGFDGHTRSDGHVYHTVHKDSGLYKDLLHKIHIDRGPEEKPAQESNYRLLRRNNSYTCYTAAICGLPVHATFRAADSSAPEDSEKLVGDTVSYSKKRLRYDSYSSYCNAVAEAEIEAEEGGVEMKLASELADPDQPREDPAEEEKEEKDAPEVHLLFHFLQVLTACFGSFAHGGNDVSNAIGPLVALWLIYKQGGVTQEAATPVWLLFYGGVGICTGLWVWGRRVIQTMGKDLTPITPSSGFTIELASAFTVVIASNIGLPVSTTHCKVGSVVAVGWIRSRKAVDWRLFRNIFVAWFVTVPVAGLFSAAVMALLMYGILPYV
  
Inhibitor
Name:
BDBM50341385
Synonyms:
CHEMBL4161567
Type:
Small organic molecule
Emp. Form.:
C18H17ClF3N5O
Mol. Mass.:
411.809
SMILES:
Cc1[nH]c2c(N3CCC4(CCNC4=O)CC3)c(C#N)c(nc2c1Cl)C(F)(F)F
Structure:
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