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Target
Folylpolyglutamate synthase, mitochondrial
Ligand
BDBM50023709
Substrate
n/a
Meas. Tech.
ChEBML_68665
Ki
185000±n/a nM
Citation
 Rosowsky, A; Forsch, RA; Moran, RG; Kohler, W; Freisheim, JH Methotrexate analogues. 32. Chain extension, alpha-carboxyl deletion, and gamma-carboxyl replacement by sulfonate and phosphonate: effect on enzyme binding and cell-growth inhibition. J Med Chem 31:1326-31 (1988) [PubMed]  Article 
Target
Name:
Folylpolyglutamate synthase, mitochondrial
Synonyms:
FOLC_HUMAN | FPGS | Folylpoly-gamma-glutamate synthetase | Folylpolyglutamate synthase, mitochondrial | Tetrahydrofolate synthase | Tetrahydrofolylpolyglutamate synthase
Type:
PROTEIN
Mol. Mass.:
64621.95
Organism:
Homo sapiens (Human)
Description:
ChEMBL_68676
Residue:
587
Sequence:
MSRARSHLRAALFLAAASARGITTQVAARRGLSAWPVPQEPSMEYQDAVRMLNTLQTNAGYLEQVKRQRGDPQTQLEAMELYLARSGLQVEDLDRLNIIHVTGTKGKGSTCAFTECILRSYGLKTGFFSSPHLVQVRERIRINGQPISPELFTKYFWRLYHRLEETKDGSCVSMPPYFRFLTLMAFHVFLQEKVDLAVVEVGIGGAYDCTNIIRKPVVCGVSSLGIDHTSLLGDTVEKIAWQKGGIFKQGVPAFTVLQPEGPLAVLRDRAQQISCPLYLCPMLEALEEGGPPLTLGLEGEHQRSNAALALQLAHCWLQRQDRHGAGEPKASRPGLLWQLPLAPVFQPTSHMRLGLRNTEWPGRTQVLRRGPLTWYLDGAHTASSAQACVRWFRQALQGRERPSGGPEVRVLLFNATGDRDPAALLKLLQPCQFDYAVFCPNLTEVSSTGNADQQNFTVTLDQVLLRCLEHQQHWNHLDEEQASPDLWSAPSPEPGGSASLLLAPHPPHTCSASSLVFSCISHALQWISQGRDPIFQPPSPPKGLLTHPVAHSGASILREAAAIHVLVTGSLHLVGGVLKLLEPALSQ
  
Inhibitor
Name:
BDBM50023709
Synonyms:
2-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-methyl-amino]-benzoylamino}-4-phosphono-butyric acid | CHEMBL27642
Type:
Small organic molecule
Emp. Form.:
C19H23N8O6P
Mol. Mass.:
490.4097
SMILES:
CN(Cc1cnc2nc(N)nc(N)c2n1)c1ccc(cc1)C(=O)NC(CCP(O)(O)=O)C(O)=O
Structure:
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