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Target
DNA topoisomerase 4 subunit B
Ligand
BDBM50470399
Substrate
n/a
Meas. Tech.
ChEMBL_1802726 (CHEMBL4275018)
IC50
23±n/a nM
Citation
Ho, SY; Wang, W; Ng, FM; Wong, YX; Poh, ZY; Tan, SWE; Ang, SH; Liew, SS; Joyner Wong, YS; Tan, Y; Poulsen, A; Pendharkar, V; Sangthongpitag, K; Manchester, J; Basarab, G; Hill, J; Keller, TH; Cherian, J Discovery of dual GyrB/ParE inhibitors active against Gram-negative bacteria. Eur J Med Chem 157:610-621 (2018) [PubMed] Article
More Info.:
Target
Name:
DNA topoisomerase 4 subunit B
Synonyms:
DNA Topoisomerase IV Subunit B | DNA topoisomerase 4 subunit B (parE) | PARE_ECOLI | nfxD | parE
Type:
Enzyme Subunit
Mol. Mass.:
70233.03
Organism:
Escherichia coli (strain K12)
Description:
n/a
Residue:
630
Sequence:
MTQTYNADAIEVLTGLEPVRRRPGMYTDTTRPNHLGQEVIDNSVDEALAGHAKRVDVILHADQSLEVIDDGRGMPVDIHPEEGVPAVELILCRLHAGGKFSNKNYQFSGGLHGVGISVVNALSKRVEVNVRRDGQVYNIAFENGEKVQDLQVVGTCGKRNTGTSVHFWPDETFFDSPRFSVSRLTHVLKAKAVLCPGVEITFKDEINNTEQRWCYQDGLNDYLAEAVNGLPTLPEKPFIGNFAGDTEAVDWALLWLPEGGELLTESYVNLIPTMQGGTHVNGLRQGLLDAMREFCEYRNILPRGVKLSAEDIWDRCAYVLSVKMQDPQFAGQTKERLSSRQCAAFVSGVVKDAFILWLNQNVQAAELLAEMAISSAQRRMRAAKKVVRKKLTSGPALPGKLADCTAQDLNRTELFLVEGDSAGGSAKQARDREYQAIMPLKGKILNTWEVSSDEVLASQEVHDISVAIGIDPDSDDLSQLRYGKICILADADSDGLHIATLLCALFVKHFRALVKHGHVYVALPPLYRIDLGKEVYYALTEEEKEGVLEQLKRKKGKPNVQRFKGLGEMNPMQLRETTLDPNTRRLVQLTIDDEDDQRTDAMMDMLLAKKRSEDRRNWLQEKGDMAEIEV