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Target
Type-2 angiotensin II receptor
Ligand
BDBM50032364
Substrate
n/a
Meas. Tech.
ChEMBL_35416 (CHEMBL643590)
IC50
10±n/a nM
Citation
 Quan, ML; Chiu, AT; Ellis, CD; Wong, PC; Wexler, RR; Timmermans, PB Balanced AT1/AT2 receptor antagonists. 4. XR510 and related 5-(3-amidopropanoyl)imidazoles possessing equal affinity for the AT1 and AT2 receptors. J Med Chem 38:2938-45 (1995) [PubMed]  Article 
Target
Name:
Type-2 angiotensin II receptor
Synonyms:
AGTR2_RAT | AT2 | Agtr2 | Angiotensin II AT2 | Angiotensin II receptor | Angiotensin II type 2 (AT-2) receptor | Type-2 angiotensin II receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
41346.62
Organism:
RAT
Description:
Angiotensin II AT2 0 0::P35351
Residue:
363
Sequence:
MKDNFSFAATSRNITSSLPFDNLNATGTNESAFNCSHKPADKHLEAIPVLYYMIFVIGFAVNIVVVSLFCCQKGPKKVSSIYIFNLAVADLLLLATLPLWATYYSYRYDWLFGPVMCKVFGSFLTLNMFASIFFITCMSVDRYQSVIYPFLSQRRNPWQASYVVPLVWCMACLSSLPTFYFRDVRTIEYLGVNACIMAFPPEKYAQWSAGIALMKNILGFIIPLIFIATCYFGIRKHLLKTNSYGKNRITRDQVLKMAAAVVLAFIICWLPFHVLTFLDALTWMGIINSCEVIAVIDLALPFAILLGFTNSCVNPFLYCFVGNRFQQKLRSVFRVPITWLQGKRETMSCRKSSSLREMDTFVS
  
Inhibitor
Name:
BDBM50032364
Synonyms:
4'-(5-Acetyl-4-ethyl-2-propyl-imidazol-1-ylmethyl)-3'-fluoro-biphenyl-2-sulfonic acid N-(butyloxycarbonyl)amide | 4'-(5-Acetyl-4-ethyl-2-propyl-imidazol-1-ylmethyl)-3'-fluoro-biphenyl-2-sulfonic acid butyloxycarbonylamide(EXP970) | CHEMBL60942 | butyloxy 2-{2-[3-flouoro-4-(4-ethyl-5-methyloxycarbonyl-2-propyl-1H-1-imidazolylmethyl)phenyl]phenylsulfonyl}carbonylamino
Type:
Small organic molecule
Emp. Form.:
C28H34FN3O5S
Mol. Mass.:
543.65
SMILES:
CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(C)=O)c(F)c1
Structure:
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