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Target
Delta-type opioid receptor
Ligand
BDBM50036790
Substrate
n/a
Meas. Tech.
ChEMBL_146647 (CHEMBL754931)
IC50
64±n/a nM
Citation
 Pitzele, BS; Hamilton, RW; Kudla, KD; Tsymbalov, S; Stapelfeld, A; Savage, MA; Clare, M; Hammond, DL; Hansen, DW Enkephalin analogs as systemically active antinociceptive agents: O- and N-alkylated derivatives of the dipeptide amide L-2,6-dimethyltyrosyl-N-(3-phenylpropyl)-D-alaninamide. J Med Chem 37:888-96 (1994) [PubMed]  Article 
Target
Name:
Delta-type opioid receptor
Synonyms:
Cytochrome P450 3A4 | DOR-1 | Delta opioid receptor | Delta-type opioid receptor | Delta-type opioid receptor (DOR) | OPIATE Delta | OPRD_RAT | Opiate Delta 1 | Opioid receptor | Opioid receptor A | Opioid receptors; mu & delta | Oprd1 | Ror-a | Voltage-gated potassium channel
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
40465.04
Organism:
Rattus norvegicus (rat)
Description:
Competition binding assays were using CHO-K1 cell membranes expressing the opioid receptor.
Residue:
372
Sequence:
MEPVPSARAELQFSLLANVSDTFPSAFPSASANASGSPGARSASSLALAIAITALYSAVCAVGLLGNVLVMFGIVRYTKLKTATNIYIFNLALADALATSTLPFQSAKYLMETWPFGELLCKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVGVPIMVMAVTQPRDGAVVCTLQFPSPSWYWDTVTKICVFLFAFVVPILIITVCYGLMLLRLRSVRLLSGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDINRRDPLVVAALHLCIALGYANSSLNPVLYAFLDENFKRCFRQLCRAPCGGQEPGSLRRPRQATARERVTACTPSDGPGGGAAA
  
Inhibitor
Name:
BDBM50036790
Synonyms:
2-Amino-3-(4-hydroxy-2,6-dimethyl-phenyl)-2-methyl-N-[(R)-1-(3-phenyl-propylcarbamoyl)-ethyl]-propionamide | CHEMBL169183
Type:
Small organic molecule
Emp. Form.:
C24H33N3O3
Mol. Mass.:
411.5371
SMILES:
C[C@@H](NC(=O)C(C)(N)Cc1c(C)cc(O)cc1C)C(=O)NCCCc1ccccc1
Structure:
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