Reaction Details Report a problem with these data
Target
Type-1 angiotensin II receptor
Ligand
BDBM50041964
Substrate
n/a
Meas. Tech.
ChEBML_36929
IC50
3.9±n/a nM
Citation
 de Laszlo, SE; Quagliato, CS; Greenlee, WJ; Patchett, AA; Chang, RS; Lotti, VJ; Chen, TB; Scheck, SA; Faust, KA; Kivlighn, SS A potent, orally active, balanced affinity angiotensin II AT1 antagonist and AT2 binding inhibitor. J Med Chem 36:3207-10 (1993) [PubMed]  Article 
Target
Name:
Type-1 angiotensin II receptor
Synonyms:
AGTR1 | AGTR1_RABIT | ANGIOTENSIN AT1 | Angiotensin II receptor | Angiotensin II type 1a (AT-1a) receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
41009.15
Organism:
RABBIT
Description:
ANGIOTENSIN AT1 AGTR1 RABBIT::P34976
Residue:
359
Sequence:
MMLNSSTEDGIKRIQDDCPKAGRHNYIFVMIPTLYSIIFVVGIFGNSLAVIVIYFYMKLKTVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNYLCKIASASVSFNLYASVFLLTCLSIDRYLAIVHPMKSRLRRTMLVAKVTCIIIWLLAGLASLPAIIHRNVFFIENTNITVCAFHYESQNSTLPIGLGLTKNILGFLFPFLIILTSYTLIWKALKKAYEIQKNKPRNDDIFKIIMAIVLFFFFSWVPHQIFTFLDVLIQLGVIHDCRIADIVDTAMPITICIAYFNNCLNPLFYGFLGKKFKKYFLQLLKYIPPKAKSHSNLSTKMSTLSYRPSDNVSSSSKKPVPCFEVE
  
Inhibitor
Name:
BDBM50041964
Synonyms:
CHEMBL110265 | {4-Oxo-2-propyl-3-[2'-(2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3,4-dihydro-quinazolin-6-yl}-carbamic acid isobutyl ester
Type:
Small organic molecule
Emp. Form.:
C30H31N7O3
Mol. Mass.:
537.6122
SMILES:
CCCc1nc2ccc(NC(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1
Structure:
Search PDB for entries with ligand similarity: