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Target
Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6
Ligand
BDBM50505020
Substrate
n/a
Meas. Tech.
ChEMBL_1816972 (CHEMBL4316546)
IC50
2440±n/a nM
Citation
 Ran, T; Xiao, R; Huang, Q; Yuan, H; Lu, T; Liu, W In Silico Discovery of JMJD6 Inhibitors for Cancer Treatment. ACS Med Chem Lett 10:1609-1613 (2019) [PubMed]  Article 
Target
Name:
Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6
Synonyms:
1.14.11.- | Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6 | Histone arginine demethylase JMJD6 | JMJD6 | JMJD6_HUMAN | JmjC domain-containing protein 6 | Jumonji domain-containing protein 6 | KIAA0585 | Lysyl-hydroxylase JMJD6 | PSR | PTDSR | Peptide-lysine 5-dioxygenase JMJD6 | Phosphatidylserine receptor | Protein PTDSR | Synonyms=KIAA0585
Type:
PROTEIN
Mol. Mass.:
46472.03
Organism:
Homo sapiens
Description:
ChEMBL_119095
Residue:
403
Sequence:
MNHKSKKRIREAKRSARPELKDSLDWTRHNYYESFSLSPAAVADNVERADALQLSVEEFVERYERPYKPVVLLNAQEGWSAQEKWTLERLKRKYRNQKFKCGEDNDGYSVKMKMKYYIEYMESTRDDSPLYIFDSSYGEHPKRRKLLEDYKVPKFFTDDLFQYAGEKRRPPYRWFVMGPPRSGTGIHIDPLGTSAWNALVQGHKRWCLFPTSTPRELIKVTRDEGGNQQDEAITWFNVIYPRTQLPTWPPEFKPLEILQKPGETVFVPGGWWHVVLNLDTTIAITQNFASSTNFPVVWHKTVRGRPKLSRKWYRILKQEHPELAVLADSVDLQESTGIASDSSSDSSSSSSSSSSDSDSECESGSEGDGTVHRRKKRRTCSMVGNGDTTSQDDCVSKERSSSR
  
Inhibitor
Name:
BDBM50505020
Synonyms:
CHEMBL4443954
Type:
Small organic molecule
Emp. Form.:
C16H11N3O2
Mol. Mass.:
277.2774
SMILES:
Cc1ccc2oc(=O)c(cc2c1)-c1nc2cnccc2[nH]1
Structure:
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