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Target
Mitogen-activated protein kinase 14
Ligand
BDBM50505888
Substrate
n/a
Meas. Tech.
ChEMBL_1824410 (CHEMBL4324174)
IC50
18±n/a nM
Citation
 Röhm, S; Berger, BT; Schröder, M; Chaikuad, A; Winkel, R; Hekking, KFW; Benningshof, JJC; Müller, G; Tesch, R; Kudolo, M; Forster, M; Laufer, S; Knapp, S Fast Iterative Synthetic Approach toward Identification of Novel Highly Selective p38 MAP Kinase Inhibitors. J Med Chem 62:10757-10782 (2019) [PubMed]  Article 
Target
Name:
Mitogen-activated protein kinase 14
Synonyms:
CSAID-binding protein | CSBP | CSBP1 | CSBP2 | CSPB1 | Cytokine suppressive anti-inflammatory drug-binding protein | MAP kinase 14 | MAP kinase MXI2 | MAP kinase p38 alpha | MAPK 14 | MAPK14 | MAX-interacting protein 2 | MK14_HUMAN | MXI2 | Mitogen-activated protein kinase p38 alpha | SAPK2A | Stress-activated protein kinase 2a | p38 MAP kinase alpha/beta
Type:
Serine/threonine-protein kinase
Mol. Mass.:
41286.76
Organism:
Homo sapiens (Human)
Description:
Q16539
Residue:
360
Sequence:
MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES
  
Inhibitor
Name:
BDBM50505888
Synonyms:
CHEMBL4476320
Type:
Small organic molecule
Emp. Form.:
C29H35N5O3
Mol. Mass.:
501.6199
SMILES:
Cc1ccc(cc1NC(=O)c1cnn(c1)-c1ccccc1C)C(=O)N[C@@H](CCC1CCCCC1)C(N)=O |r|
Structure:
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